ID   ELP6_RAT                Reviewed;         266 AA.
AC   B2RYG8;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Elongator complex protein 6;
GN   Name=Elp6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the elongator complex which is required for
CC       multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl
CC       uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U
CC       (5-carbamoylmethyl uridine) (By similarity). The elongator complex
CC       catalyzes formation of carboxymethyluridine in the wobble base at
CC       position 34 in tRNAs (By similarity). Involved in cell migration (By
CC       similarity). {ECO:0000250|UniProtKB:Q0PNE2,
CC       ECO:0000250|UniProtKB:Q8BK75}.
CC   -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC       biosynthesis. {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- SUBUNIT: Component of the elongator complex which consists of ELP1,
CC       ELP2, ELP3, ELP4, ELP5 and ELP6. {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- SIMILARITY: Belongs to the ELP6 family. {ECO:0000305}.
CC   -!- CAUTION: The elongator complex was originally thought to play a role in
CC       transcription elongation. However, it is no longer thought to play a
CC       direct role in this process and its primary function is thought to be
CC       in tRNA modification. {ECO:0000250|UniProtKB:Q0PNE2}.
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DR   EMBL; CH473954; EDL77087.1; -; Genomic_DNA.
DR   EMBL; BC166773; AAI66773.1; -; mRNA.
DR   RefSeq; NP_001102252.1; NM_001108782.2.
DR   AlphaFoldDB; B2RYG8; -.
DR   BioGRID; 263997; 1.
DR   STRING; 10116.ENSRNOP00000028288; -.
DR   jPOST; B2RYG8; -.
DR   PaxDb; B2RYG8; -.
DR   PeptideAtlas; B2RYG8; -.
DR   Ensembl; ENSRNOT00000028288; ENSRNOP00000028288; ENSRNOG00000020847.
DR   GeneID; 363150; -.
DR   KEGG; rno:363150; -.
DR   CTD; 54859; -.
DR   RGD; 1305478; Elp6.
DR   eggNOG; KOG4723; Eukaryota.
DR   GeneTree; ENSGT00390000011734; -.
DR   HOGENOM; CLU_092581_2_0_1; -.
DR   InParanoid; B2RYG8; -.
DR   OMA; MFTELNS; -.
DR   OrthoDB; 1272502at2759; -.
DR   PhylomeDB; B2RYG8; -.
DR   TreeFam; TF331346; -.
DR   UniPathway; UPA00988; -.
DR   PRO; PR:B2RYG8; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Proteomes; UP000234681; Chromosome 8.
DR   Bgee; ENSRNOG00000020847; Expressed in pancreas and 20 other tissues.
DR   Genevisible; B2RYG8; RN.
DR   GO; GO:0005829; C:cytosol; ISO:RGD.
DR   GO; GO:0033588; C:elongator holoenzyme complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR018627; ELP6.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR16184; PTHR16184; 1.
DR   Pfam; PF09807; ELP6; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; tRNA processing.
FT   CHAIN           1..266
FT                   /note="Elongator complex protein 6"
FT                   /id="PRO_0000351071"
SQ   SEQUENCE   266 AA;  29459 MW;  EDFA31A1E5D27E33 CRC64;
     MFPELNNLLS ITPDRTEQGK LTLLCDAKTD GSFLVHHFLS FYLKANCKVC FVALVQSFSH
     YNIVGQKLGV SLTAARERGQ LVFLEGLKSS VEVLFHSQEE PHPLQFLREA GAGNLQSLYT
     FIQDTLKPAD SGESPWKCPV LLVDNLSVLL SLGVGAVAVL DFMQYCRATV CCELKGNVVA
     LVHDTEGAED EENNILLNGL SHQSHLILRT QGLATGFCKD VHGQLSILWR RSSQPTAQRA
     RSLTYQYKIQ DKNVSFFAKG MSRAVL