ID   ELP6_XENLA              Reviewed;         265 AA.
AC   Q0IHA2;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Elongator complex protein 6;
DE   AltName: Full=Protein TMEM103;
GN   Name=elp6; Synonyms=tmem103;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the elongator complex which is required for
CC       multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl
CC       uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U
CC       (5-carbamoylmethyl uridine) (By similarity). The elongator complex
CC       catalyzes formation of carboxymethyluridine in the wobble base at
CC       position 34 in tRNAs (By similarity). {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC       biosynthesis. {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- SUBUNIT: Component of the elongator complex.
CC       {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- SIMILARITY: Belongs to the ELP6 family. {ECO:0000305}.
CC   -!- CAUTION: The elongator complex was originally thought to play a role in
CC       transcription elongation. However, it is no longer thought to play a
CC       direct role in this process and its primary function is thought to be
CC       in tRNA modification. {ECO:0000250|UniProtKB:Q0PNE2}.
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DR   EMBL; BC123243; AAI23244.1; -; mRNA.
DR   RefSeq; NP_001090365.1; NM_001096896.1.
DR   AlphaFoldDB; Q0IHA2; -.
DR   SMR; Q0IHA2; -.
DR   BioGRID; 607983; 1.
DR   IntAct; Q0IHA2; 1.
DR   DNASU; 779276; -.
DR   GeneID; 779276; -.
DR   KEGG; xla:779276; -.
DR   CTD; 779276; -.
DR   Xenbase; XB-GENE-5919932; elp6.L.
DR   OrthoDB; 1272502at2759; -.
DR   UniPathway; UPA00988; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 779276; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0033588; C:elongator holoenzyme complex; ISS:UniProtKB.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR018627; ELP6.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR16184; PTHR16184; 1.
DR   Pfam; PF09807; ELP6; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; tRNA processing.
FT   CHAIN           1..265
FT                   /note="Elongator complex protein 6"
FT                   /id="PRO_0000274363"
SQ   SEQUENCE   265 AA;  29029 MW;  18296C3A7E61B461 CRC64;
     MFPELNSLLG VTTDTLTLGK FTLLCDSNTD GSFLVHHFLS YYLRAGCRVC FVALVQSFSH
     YNIVAQKLGV NLSSAKDEGQ LVFLEGLKSY TDLLFGDKSE AEETNPLCFL RAGSDLRPLY
     SFVSAALAPS AGQPWKCPVL ILDDLSVLLS LGVTSLQVLD FMHYCRATVC TQYKGNVLCL
     VHGAEESGDE ENELVLRSLS HQSHLILQAE GLSTGFCKDV HGQLKIIRGA VSSGKRGKNQ
     PEIYQYKIQD KHVAFFARGL SAAVL