ID   ELP6_XENTR              Reviewed;         266 AA.
AC   Q28CX0; Q66KC5;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 2.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Elongator complex protein 6;
DE   AltName: Full=Protein TMEM103;
GN   Name=elp6; Synonyms=tmem103; ORFNames=TTpA007a13.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the elongator complex which is required for
CC       multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl
CC       uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U
CC       (5-carbamoylmethyl uridine) (By similarity). The elongator complex
CC       catalyzes formation of carboxymethyluridine in the wobble base at
CC       position 34 in tRNAs (By similarity). {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC       biosynthesis. {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- SUBUNIT: Component of the elongator complex.
CC       {ECO:0000250|UniProtKB:Q0PNE2}.
CC   -!- SIMILARITY: Belongs to the ELP6 family. {ECO:0000305}.
CC   -!- CAUTION: The elongator complex was originally thought to play a role in
CC       transcription elongation. However, it is no longer thought to play a
CC       direct role in this process and its primary function is thought to be
CC       in tRNA modification. {ECO:0000250|UniProtKB:Q0PNE2}.
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DR   EMBL; CR855827; CAJ83123.1; -; mRNA.
DR   EMBL; BC080461; AAH80461.1; -; mRNA.
DR   RefSeq; NP_001007953.2; NM_001007952.2.
DR   AlphaFoldDB; Q28CX0; -.
DR   SMR; Q28CX0; -.
DR   STRING; 8364.ENSXETP00000030460; -.
DR   PaxDb; Q28CX0; -.
DR   DNASU; 493328; -.
DR   GeneID; 493328; -.
DR   KEGG; xtr:493328; -.
DR   CTD; 54859; -.
DR   Xenbase; XB-GENE-5919888; elp6.
DR   eggNOG; KOG4723; Eukaryota.
DR   InParanoid; Q28CX0; -.
DR   OrthoDB; 1272502at2759; -.
DR   UniPathway; UPA00988; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0033588; C:elongator holoenzyme complex; ISS:UniProtKB.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR018627; ELP6.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR16184; PTHR16184; 1.
DR   Pfam; PF09807; ELP6; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; tRNA processing.
FT   CHAIN           1..266
FT                   /note="Elongator complex protein 6"
FT                   /id="PRO_0000274364"
FT   CONFLICT        208
FT                   /note="W -> R (in Ref. 1; CAJ83123)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   266 AA;  29235 MW;  D54976D9A23868AD CRC64;
     MFPELNSLLG AGTDTVERGK FTLLCDSKTD GSFLVHHFLS YYLRAGCRVC FVALVQSFSH
     YSIVAQKLGV NLSSAKDEGQ LVFLEGLRSY TDLLFGDNPE AEVTNPLCFL RAGSDLKPLY
     SFVSAALAPS AGQSWKCPVL ILDDVSVLLS LGVPPLQLLD FMHYCRATVC TQYQGNVVCL
     VHGAEESGDE EKELLRRSLS HQSQVILWAE GLSSGFCKEV HGQLKIFRGA VSSGKKRGQT
     QPEIYQYKIQ DKHVTFFARG LSAAVL