ELT4_CAEEL
ID ELT4_CAEEL Reviewed; 72 AA.
AC Q8MQA7; D0VWN0;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Probable transcription factor elt-4 {ECO:0000305};
DE AltName: Full=GATA-type domain-containing protein elt-4 {ECO:0000305};
GN Name=elt-4 {ECO:0000312|WormBase:C39B10.6a};
GN ORFNames=C39B10.6 {ECO:0000312|WormBase:C39B10.6a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=14573471; DOI=10.1093/genetics/165.2.575;
RA Fukushige T., Goszczynski B., Tian H., McGhee J.D.;
RT "The evolutionary duplication and probable demise of an endodermal GATA
RT factor in Caenorhabditis elegans.";
RL Genetics 165:575-588(2003).
RN [3] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20938051; DOI=10.1074/jbc.m110.167619;
RA Sinclair J., Hamza I.;
RT "A novel heme-responsive element mediates transcriptional regulation in
RT Caenorhabditis elegans.";
RL J. Biol. Chem. 285:39536-39543(2010).
RN [4] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24834345; DOI=10.1186/2046-2395-3-5;
RA Bansal A., Kwon E.S., Conte D. Jr., Liu H., Gilchrist M.J., MacNeil L.T.,
RA Tissenbaum H.A.;
RT "Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates
RT lifespan.";
RL Longev. Healthspan 3:5-5(2014).
CC -!- FUNCTION: Probable transcription factor (PubMed:20938051,
CC PubMed:24834345). Plays a role in regulating heme-dependent expression
CC of heme transporter hrg-1 (PubMed:20938051). Modulates lifespan in a
CC daf-16-dependent manner (PubMed:24834345).
CC {ECO:0000269|PubMed:20938051, ECO:0000269|PubMed:24834345}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:20938051,
CC ECO:0000305|PubMed:24834345}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:C39B10.6a};
CC IsoId=Q8MQA7-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:C39B10.6b};
CC IsoId=Q8MQA7-2; Sequence=VSP_061352, VSP_061353;
CC -!- DEVELOPMENTAL STAGE: Expressed at the 1.5-fold stage of embryogenesis
CC and by the 3-fold stage, in all cells of the gut (PubMed:14573471).
CC Expressed in nine cells in the posterior bulb of the pharynx from the
CC 3-fold stage (PubMed:14573471). Expressed in the intestine at all
CC stages of development (PubMed:14573471). {ECO:0000269|PubMed:14573471}.
CC -!- DISRUPTION PHENOTYPE: No phenotype detected and so may be dispensable
CC (PubMed:14573471). RNAi-mediated knockdown causes intestinal expression
CC of heme transporter hrg-1 induced by heme to be reduced drastically in
CC L3 stage larvae (PubMed:20938051). Reduces expression of the daf-16
CC isoforms d and f (PubMed:24834345). {ECO:0000269|PubMed:14573471,
CC ECO:0000269|PubMed:20938051, ECO:0000269|PubMed:24834345}.
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DR EMBL; BX284606; CBH29655.2; -; Genomic_DNA.
DR EMBL; BX284606; CAD44111.1; -; Genomic_DNA.
DR RefSeq; NP_001257105.1; NM_001270176.1.
DR AlphaFoldDB; Q8MQA7; -.
DR SMR; Q8MQA7; -.
DR IntAct; Q8MQA7; 2.
DR STRING; 6239.C39B10.6a; -.
DR PaxDb; Q8MQA7; -.
DR EnsemblMetazoa; C39B10.6a.1; C39B10.6a.1; WBGene00001252. [Q8MQA7-1]
DR EnsemblMetazoa; C39B10.6b.1; C39B10.6b.1; WBGene00001252. [Q8MQA7-2]
DR GeneID; 181249; -.
DR KEGG; cel:CELE_C39B10.6; -.
DR UCSC; C39B10.6; c. elegans. [Q8MQA7-1]
DR CTD; 181249; -.
DR WormBase; C39B10.6a; CE31441; WBGene00001252; elt-4.
DR WormBase; C39B10.6b; CE51998; WBGene00001252; elt-4.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00970000196325; -.
DR HOGENOM; CLU_2724521_0_0_1; -.
DR InParanoid; Q8MQA7; -.
DR OMA; NYLDASH; -.
DR OrthoDB; 1466754at2759; -.
DR PhylomeDB; Q8MQA7; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00001252; Expressed in larva and 2 other tissues.
DR ExpressionAtlas; Q8MQA7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:WormBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR Pfam; PF00320; GATA; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 2: Evidence at transcript level;
KW Alternative initiation; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..72
FT /note="Probable transcription factor elt-4"
FT /id="PRO_0000454564"
FT ZN_FING 16..40
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT VAR_SEQ 1..48
FT /note="MDNNYLDASHRKRLVCSNCNGTNTTLWRRKAEGDPVCNACGLYFKLHH ->
FT MLLIGNGLYAPIAMVRTQLSGEEKLKEIQSAMLVDYISSFITLPAPSQ (in
FT isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061352"
FT VAR_SEQ 49..72
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061353"
SQ SEQUENCE 72 AA; 8131 MW; 5CCABAA25805512A CRC64;
MDNNYLDASH RKRLVCSNCN GTNTTLWRRK AEGDPVCNAC GLYFKLHHVT RPIPMKKNKK
HAVLPAPGIS KL
