ELYC_ECOLI
ID ELYC_ECOLI Reviewed; 259 AA.
AC P0AB01; P36565; P75846;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Envelope biogenesis factor ElyC;
DE AltName: Full=Elevated frequency of lysis;
GN Name=elyC; Synonyms=ycbC; OrderedLocusNames=b0920, JW0903;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-170.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=7513784; DOI=10.1007/bf00280310;
RA Feng J., Yamanaka K., Niki H., Ogura T., Hiraga S.;
RT "New killing system controlled by two genes located immediately upstream of
RT the mukB gene in Escherichia coli.";
RL Mol. Gen. Genet. 243:136-147(1994).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, AND GENE NAME.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=24391520; DOI=10.1371/journal.pgen.1004056;
RA Paradis-Bleau C., Kritikos G., Orlova K., Typas A., Bernhardt T.G.;
RT "A genome-wide screen for bacterial envelope biogenesis mutants identifies
RT a novel factor involved in cell wall precursor metabolism.";
RL PLoS Genet. 10:E1004056-E1004056(2014).
CC -!- FUNCTION: Plays a critical role in the metabolism of the essential
CC lipid carrier used for cell wall synthesis.
CC {ECO:0000269|PubMed:24391520}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Deletion causes a severe growth defect at low
CC temperature and an elevated frequency of cell lysis resulting from
CC impaired metabolism of the essential lipid precursor required for
CC peptidoglycan synthesis. {ECO:0000269|PubMed:24391520}.
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DR EMBL; U00096; AAC74006.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA35666.1; -; Genomic_DNA.
DR EMBL; D26440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; G64831; G64831.
DR RefSeq; NP_415440.1; NC_000913.3.
DR RefSeq; WP_000899600.1; NZ_SSZK01000002.1.
DR AlphaFoldDB; P0AB01; -.
DR BioGRID; 4263426; 298.
DR BioGRID; 849920; 2.
DR IntAct; P0AB01; 3.
DR STRING; 511145.b0920; -.
DR jPOST; P0AB01; -.
DR PaxDb; P0AB01; -.
DR PRIDE; P0AB01; -.
DR EnsemblBacteria; AAC74006; AAC74006; b0920.
DR EnsemblBacteria; BAA35666; BAA35666; BAA35666.
DR GeneID; 945546; -.
DR KEGG; ecj:JW0903; -.
DR KEGG; eco:b0920; -.
DR PATRIC; fig|511145.12.peg.951; -.
DR EchoBASE; EB2085; -.
DR eggNOG; COG1434; Bacteria.
DR HOGENOM; CLU_053514_0_0_6; -.
DR InParanoid; P0AB01; -.
DR OMA; LWFTRWQ; -.
DR PhylomeDB; P0AB01; -.
DR BioCyc; EcoCyc:EG12166-MON; -.
DR PRO; PR:P0AB01; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0043164; P:Gram-negative-bacterium-type cell wall biogenesis; IMP:EcoCyc.
DR GO; GO:0000270; P:peptidoglycan metabolic process; IMP:EcoCyc.
DR GO; GO:0006457; P:protein folding; IMP:EcoCyc.
DR CDD; cd06259; YdcF-like; 1.
DR Gene3D; 3.40.50.620; -; 1.
DR InterPro; IPR003848; DUF218.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR Pfam; PF02698; DUF218; 1.
PE 4: Predicted;
KW Cell inner membrane; Cell membrane; Cell wall biogenesis/degradation;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..259
FT /note="Envelope biogenesis factor ElyC"
FT /id="PRO_0000168768"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 89
FT /note="Y -> N (in Ref. 4; D26440)"
FT /evidence="ECO:0000305"
FT CONFLICT 150..170
FT /note="GVPREQIITLDLPKDTEEEAA -> ACRASKLSPWICQKIPKKKLQ (in
FT Ref. 4; D26440)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 259 AA; 28666 MW; 7EAE14C696DAA0C9 CRC64;
MLFTLKKVIG NMLLPLPLML LIIGAGLALL WFSRFQKTGK IFISIGWLAL LLLSLQPVAD
RLLRPIESTY PTWNNSQKVD YIVVLGGGYT WNPQWAPSSN LINNSLPRLN EGIRLWRENP
GSKLIFTGGV AKTNTVSTAE VGARVAQSLG VPREQIITLD LPKDTEEEAA AVKQAIGDAP
FLLVTSASHL PRAMIFFQQE GLNPLPAPAN QLAIDSPLNP WERAIPSPVW LMHSDRVGYE
TLGRIWQWLK GSSGEPRQE
