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ELYS_CHATD
ID   ELYS_CHATD              Reviewed;         299 AA.
AC   G0S2G1; G0ZGV2;
DT   24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Protein ELYS {ECO:0000303|PubMed:21784248};
GN   Name=ELYS; ORFNames=CTHT_0017110;
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: Required for the assembly of a functional nuclear pore
CC       complex (NPC). {ECO:0000250|UniProtKB:Q8WYP5}.
CC   -!- SUBUNIT: The nuclear pore complex (NPC) constitutes the exclusive means
CC       of nucleocytoplasmic transport. NPCs allow the passive diffusion of
CC       ions and small molecules and the active, nuclear transport receptor-
CC       mediated bidirectional transport of macromolecules such as proteins,
CC       RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the
CC       nuclear envelope. The 55-60 MDa NPC is composed of at least 28
CC       different subunits: AMO1, ELYS, GLE1, GLE2, MLP1, NDC1, NIC96, NSP1,
CC       NUP133, NUP145, NUP152, NUP159, NUP170, NUP188, NUP192, NUP37, NUP49,
CC       NUP53, NUP56, NUP57, NUP82, NUP84, NUP85, POM152, POM33, POM34, SEC13
CC       and SEH1. Due to its 8-fold rotational symmetry, all subunits are
CC       present with 8 copies or multiples thereof.
CC       {ECO:0000250|UniProtKB:Q8WYP5, ECO:0000305|PubMed:21784248}.
CC   -!- INTERACTION:
CC       G0S2G1; G0S0E7: NUP120; NbExp=6; IntAct=EBI-16069391, EBI-16069242;
CC       G0S2G1; G0SAK3: NUP145; NbExp=5; IntAct=EBI-16069391, EBI-16069276;
CC       G0S2G1; G0SDQ4: NUP85; NbExp=7; IntAct=EBI-16069391, EBI-16069259;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:Q8WYP5}.
CC   -!- SIMILARITY: Belongs to the ELYS family. {ECO:0000305}.
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DR   EMBL; GL988040; EGS22194.1; -; Genomic_DNA.
DR   EMBL; JF276296; AEL00690.1; -; Genomic_DNA.
DR   RefSeq; XP_006692213.1; XM_006692150.1.
DR   AlphaFoldDB; G0S2G1; -.
DR   DIP; DIP-60576N; -.
DR   IntAct; G0S2G1; 7.
DR   STRING; 759272.G0S2G1; -.
DR   TCDB; 1.I.1.1.2; the nuclear pore complex (npc) family.
DR   EnsemblFungi; EGS22194; EGS22194; CTHT_0017110.
DR   GeneID; 18255749; -.
DR   KEGG; cthr:CTHT_0017110; -.
DR   eggNOG; ENOG502S4G4; Eukaryota.
DR   HOGENOM; CLU_070360_0_0_1; -.
DR   OrthoDB; 539794at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR025151; ELYS_dom.
DR   Pfam; PF13934; ELYS; 1.
PE   1: Evidence at protein level;
KW   mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Translocation; Transport.
FT   CHAIN           1..299
FT                   /note="Protein ELYS"
FT                   /id="PRO_0000433194"
SQ   SEQUENCE   299 AA;  33051 MW;  85B3B12EB1C9BFC5 CRC64;
     MLDFTHFPEV FPTDGPRPYD QHFVRQTETF RKSLDGVLFI DRVLGALGLP DAAKAYPPRG
     DAGLRALHQQ VCSAKVSAHA KLSVLYYLLL DHDEHRGSRS QLADALAEEV GLPANYQILM
     RGLWHMDRKE FKFALEHLAH PSLPAEFADE IITVLVRDGH TTGDYSLPLA YYHAVRPVLQ
     TSSALENLFA ALARTSVTDA LAFSRTYPDH GARQLLFERL VASVLEEHGS GQVAGRSASR
     AKELVSLPLT GVEEKWLNDY LSTGEGRKSR SAKAVVQMRQ VVTGRQKELG AVVGVRAGR
 
 
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