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ELYS_HALCR
ID   ELYS_HALCR              Reviewed;         156 AA.
AC   Q01380;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Egg-lysin;
DE   AltName: Full=Sperm-lysin;
DE   Flags: Precursor;
OS   Haliotis cracherodii (Black abalone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Vetigastropoda; Lepetellida; Haliotoidea; Haliotidae; Haliotis.
OX   NCBI_TaxID=6455;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Lee Y.H., Vacquier V.D.;
RT   "The divergence of species-specific abalone sperm lysins is promoted by
RT   positive Darwinian selection.";
RL   Biol. Bull. 182:97-104(1992).
CC   -!- FUNCTION: Creates a 3 um hole in the egg vitelline layer through which
CC       the sperm passes. Does not have enzyme activity. Species-specific
CC       interaction between the sperm protein lysin and the egg protein VERL
CC       exposes a basic surface on lysin that may dissociate the egg vitelline
CC       layer via electrostatic repulsion. Plays a role in ensuring species-
CC       specific fertilization. {ECO:0000250|UniProtKB:P04552}.
CC   -!- SUBUNIT: Monomer. Homodimer. Molecules associate into dimers and then
CC       rapidly dissociate again. Interacts (as a monomer) with the egg
CC       vitelline layer protein VERL (via VERL repeats); each VERL chain can
CC       bind multiple copies of lysin. {ECO:0000250|UniProtKB:P04552}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC       lumen {ECO:0000250|UniProtKB:P04552}.
CC   -!- TISSUE SPECIFICITY: Sperm. {ECO:0000305}.
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DR   EMBL; M59971; AAA29201.1; -; mRNA.
DR   AlphaFoldDB; Q01380; -.
DR   SMR; Q01380; -.
DR   GO; GO:0043160; C:acrosomal lumen; ISS:UniProtKB.
DR   GO; GO:0007338; P:single fertilization; ISS:UniProtKB.
DR   CDD; cd00243; Lysin-Sp18; 1.
DR   Gene3D; 1.20.150.10; -; 1.
DR   InterPro; IPR001379; Egg_lysin.
DR   InterPro; IPR035916; Fertil_protein_sf.
DR   Pfam; PF01303; Egg_lysin; 1.
DR   PRINTS; PR01882; LYSIN.
DR   SUPFAM; SSF47082; SSF47082; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Fertilization; Signal.
FT   SIGNAL          1..18
FT   CHAIN           19..156
FT                   /note="Egg-lysin"
FT                   /id="PRO_0000021167"
SQ   SEQUENCE   156 AA;  18657 MW;  6E9EF98E72D0CA32 CRC64;
     MKLLVLCVFA MMATLAVSRR YQFVQHQYIR KAFEVALKVE IIAGFDRTLV KWLRNHGRGL
     NENQRKVLYF VNRRYMQTHW QNYMLWIVKK TNALGRPPVV ADYRALGAEI GRRIDMGYFY
     NFLKNRVMIP KYLPYMRRLN NMRPEDVPVA NRNPGK
 
 
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