ID   ELYS_HALKA              Reviewed;         154 AA.
AC   Q01382;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Egg-lysin;
DE   AltName: Full=Sperm-lysin;
DE   Flags: Precursor;
OS   Haliotis kamtschatkana (Pinto abalone) (Northern abalone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Vetigastropoda; Lepetellida; Haliotoidea; Haliotidae; Haliotis.
OX   NCBI_TaxID=6457;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Lee Y.H., Vacquier V.D.;
RT   "The divergence of species-specific abalone sperm lysins is promoted by
RT   positive Darwinian selection.";
RL   Biol. Bull. 182:97-104(1992).
CC   -!- FUNCTION: Dissolves the egg vitelline layer nonenzymatically during
CC       fertilization. It creates a hole of about 3 mu-m in diameter through
CC       which the sperm pass.
CC   -!- SUBUNIT: Homodimer.
CC   -!- TISSUE SPECIFICITY: Sperm.
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DR   EMBL; M59970; AAA29200.1; -; mRNA.
DR   AlphaFoldDB; Q01382; -.
DR   SMR; Q01382; -.
DR   GO; GO:0043160; C:acrosomal lumen; ISS:UniProtKB.
DR   GO; GO:0007338; P:single fertilization; ISS:UniProtKB.
DR   CDD; cd00243; Lysin-Sp18; 1.
DR   Gene3D; 1.20.150.10; -; 1.
DR   InterPro; IPR001379; Egg_lysin.
DR   InterPro; IPR035916; Fertil_protein_sf.
DR   Pfam; PF01303; Egg_lysin; 1.
DR   PRINTS; PR01882; LYSIN.
DR   SUPFAM; SSF47082; SSF47082; 1.
PE   2: Evidence at transcript level;
KW   Fertilization; Signal.
FT   SIGNAL          1..18
FT   CHAIN           19..154
FT                   /note="Egg-lysin"
FT                   /id="PRO_0000021169"
SQ   SEQUENCE   154 AA;  18386 MW;  8875D2B9E6CF3564 CRC64;
     MKLFVLCIFA MMATLAMSRS WTYVQPKFLN KAFEVALKEE IIVRWDRKLA KWLRVNGGPL
     SHVQKKALYF VNRRYMQTHW ANYMLWINKK TDALGRTPVV GDYRRLGAEI GRRIDMVFFY
     KFLSGRNMIP KYMPYMEQIN RMRAADIPVK YMGK