ID   EM1_CONVC               Reviewed;          90 AA.
AC   W4VS70;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Conotoxin Vc22.1 {ECO:0000305};
DE   AltName: Full=E_Vc1 {ECO:0000303|PubMed:24505301};
DE   Flags: Precursor;
OS   Conus victoriae (Queen Victoria cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=319920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=24505301; DOI=10.1371/journal.pone.0087648;
RA   Robinson S.D., Safavi-Hemami H., McIntosh L.D., Purcell A.W., Norton R.S.,
RA   Papenfuss A.T.;
RT   "Diversity of conotoxin gene superfamilies in the venomous snail, Conus
RT   victoriae.";
RL   PLoS ONE 9:E87648-E87648(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24505301}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:24505301}.
CC   -!- DOMAIN: The cysteine framework is XXII (C-C-C-C-C-C-C-C).
CC       {ECO:0000305}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the E superfamily. {ECO:0000305}.
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DR   EMBL; GAIH01000007; JAB84710.1; -; mRNA.
DR   AlphaFoldDB; W4VS70; -.
DR   TCDB; 8.B.1.4.3; the long (4c-c) scorpion toxin (l-st) superfamily.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..90
FT                   /note="Conotoxin Vc22.1"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5004850809"
SQ   SEQUENCE   90 AA;  10551 MW;  D1713E7626F02F2E CRC64;
     MMTRVFLAMF FLLVLTKGWP RLYDGDCTRG PNMHITCFKD QSCGLIVKRN GRLSCTLNCK
     CRRNESCLPS EEVDWDNRNM KIVICPKPWF