EMAL5_HUMAN
ID EMAL5_HUMAN Reviewed; 1969 AA.
AC Q05BV3; B9EK59; Q5H9N6; Q6UYC9; Q6ZRP3; Q6ZT03;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Echinoderm microtubule-associated protein-like 5;
DE Short=EMAP-5;
GN Name=EML5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-658 (ISOFORM 1).
RC TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 419-1969 (ISOFORM 4), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1085-1969 (ISOFORM 2).
RC TISSUE=Brain, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 502-1059 (ISOFORM 1).
RC TISSUE=Retina;
RA Bonner T.I.;
RT "Partial coding sequence of a WD40 repeat containing protein from retina
RT and brain.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1664-1969.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q05BV3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q05BV3-2; Sequence=VSP_041260, VSP_041261;
CC Name=4;
CC IsoId=Q05BV3-4; Sequence=VSP_041258, VSP_041259;
CC Name=5;
CC IsoId=Q05BV3-5; Sequence=VSP_040645;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH32685.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAC86793.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=BAC87266.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=CAI46257.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown in N-terminus because it seems to be derived from a pre-mRNA.; Evidence={ECO:0000305};
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DR EMBL; AK127024; BAC86793.1; ALT_SEQ; mRNA.
DR EMBL; AK128086; BAC87266.1; ALT_SEQ; mRNA.
DR EMBL; AL121768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL162171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032685; AAH32685.1; ALT_SEQ; mRNA.
DR EMBL; BC150639; AAI50640.1; -; mRNA.
DR EMBL; AY357725; AAQ62653.1; -; mRNA.
DR EMBL; CR933726; CAI46257.1; ALT_SEQ; Transcribed_RNA.
DR CCDS; CCDS45148.1; -. [Q05BV3-5]
DR RefSeq; NP_899243.1; NM_183387.2. [Q05BV3-5]
DR RefSeq; XP_006720133.1; XM_006720070.3. [Q05BV3-1]
DR AlphaFoldDB; Q05BV3; -.
DR SMR; Q05BV3; -.
DR BioGRID; 127791; 15.
DR IntAct; Q05BV3; 7.
DR STRING; 9606.ENSP00000451998; -.
DR iPTMnet; Q05BV3; -.
DR PhosphoSitePlus; Q05BV3; -.
DR BioMuta; EML5; -.
DR DMDM; 215274143; -.
DR EPD; Q05BV3; -.
DR jPOST; Q05BV3; -.
DR MassIVE; Q05BV3; -.
DR MaxQB; Q05BV3; -.
DR PaxDb; Q05BV3; -.
DR PeptideAtlas; Q05BV3; -.
DR PRIDE; Q05BV3; -.
DR ProteomicsDB; 58380; -. [Q05BV3-1]
DR ProteomicsDB; 58381; -. [Q05BV3-2]
DR ProteomicsDB; 58382; -. [Q05BV3-4]
DR ProteomicsDB; 58383; -. [Q05BV3-5]
DR Antibodypedia; 47387; 37 antibodies from 16 providers.
DR DNASU; 161436; -.
DR Ensembl; ENST00000380664.9; ENSP00000370039.5; ENSG00000165521.16. [Q05BV3-1]
DR Ensembl; ENST00000554922.6; ENSP00000451998.1; ENSG00000165521.16. [Q05BV3-5]
DR GeneID; 161436; -.
DR KEGG; hsa:161436; -.
DR MANE-Select; ENST00000554922.6; ENSP00000451998.1; NM_183387.3; NP_899243.1. [Q05BV3-5]
DR UCSC; uc059edd.1; human. [Q05BV3-1]
DR CTD; 161436; -.
DR DisGeNET; 161436; -.
DR GeneCards; EML5; -.
DR HGNC; HGNC:18197; EML5.
DR HPA; ENSG00000165521; Tissue enhanced (brain, ovary, retina).
DR MIM; 618119; gene.
DR neXtProt; NX_Q05BV3; -.
DR OpenTargets; ENSG00000165521; -.
DR PharmGKB; PA134894613; -.
DR VEuPathDB; HostDB:ENSG00000165521; -.
DR eggNOG; KOG2106; Eukaryota.
DR GeneTree; ENSGT00940000156613; -.
DR HOGENOM; CLU_001930_0_0_1; -.
DR InParanoid; Q05BV3; -.
DR OMA; LVQWATW; -.
DR OrthoDB; 97584at2759; -.
DR PhylomeDB; Q05BV3; -.
DR TreeFam; TF317832; -.
DR PathwayCommons; Q05BV3; -.
DR SignaLink; Q05BV3; -.
DR BioGRID-ORCS; 161436; 9 hits in 1071 CRISPR screens.
DR ChiTaRS; EML5; human.
DR GenomeRNAi; 161436; -.
DR Pharos; Q05BV3; Tdark.
DR PRO; PR:Q05BV3; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q05BV3; protein.
DR Bgee; ENSG00000165521; Expressed in left ovary and 106 other tissues.
DR ExpressionAtlas; Q05BV3; baseline and differential.
DR Genevisible; Q05BV3; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 6.
DR InterPro; IPR024977; Apc4_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12894; ANAPC4_WD40; 2.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 8.
DR SMART; SM00320; WD40; 28.
DR SUPFAM; SSF50952; SSF50952; 1.
DR SUPFAM; SSF50978; SSF50978; 3.
DR SUPFAM; SSF50998; SSF50998; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Microtubule;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1969
FT /note="Echinoderm microtubule-associated protein-like 5"
FT /id="PRO_0000284395"
FT REPEAT 59..100
FT /note="WD 1"
FT REPEAT 104..145
FT /note="WD 2"
FT REPEAT 148..187
FT /note="WD 3"
FT REPEAT 195..233
FT /note="WD 4"
FT REPEAT 235..273
FT /note="WD 5"
FT REPEAT 280..321
FT /note="WD 6"
FT REPEAT 323..362
FT /note="WD 7"
FT REPEAT 406..445
FT /note="WD 8"
FT REPEAT 449..488
FT /note="WD 9"
FT REPEAT 561..601
FT /note="WD 10"
FT REPEAT 725..766
FT /note="WD 11"
FT REPEAT 770..811
FT /note="WD 12"
FT REPEAT 814..853
FT /note="WD 13"
FT REPEAT 861..900
FT /note="WD 14"
FT REPEAT 901..940
FT /note="WD 15"
FT REPEAT 996..1035
FT /note="WD 16"
FT REPEAT 1038..1077
FT /note="WD 17"
FT REPEAT 1080..1120
FT /note="WD 18"
FT REPEAT 1236..1276
FT /note="WD 19"
FT REPEAT 1412..1463
FT /note="WD 20"
FT REPEAT 1467..1508
FT /note="WD 21"
FT REPEAT 1511..1550
FT /note="WD 22"
FT REPEAT 1560..1598
FT /note="WD 23"
FT REPEAT 1600..1646
FT /note="WD 24"
FT REPEAT 1691..1731
FT /note="WD 25"
FT REPEAT 1733..1774
FT /note="WD 26"
FT REPEAT 1775..1814
FT /note="WD 27"
FT REPEAT 1887..1926
FT /note="WD 28"
FT REPEAT 1932..1969
FT /note="WD 29"
FT REGION 609..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1274..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1326..1355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 609..622
FT /note="ESLADSHSDESDSD -> GYIHLYLHRHLNLM (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_041258"
FT VAR_SEQ 623..1969
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_041259"
FT VAR_SEQ 1137..1144
FT /note="GKLLQVNT -> AFTGQHWC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_041260"
FT VAR_SEQ 1145..1969
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_041261"
FT VAR_SEQ 1334
FT /note="E -> ERQGVVRGS (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040645"
FT VARIANT 269
FT /note="I -> V (in dbSNP:rs17188228)"
FT /id="VAR_031730"
FT CONFLICT 317
FT /note="F -> S (in Ref. 2; AAH32685)"
FT /evidence="ECO:0000305"
FT CONFLICT 1402
FT /note="V -> A (in Ref. 3; BAC86793)"
FT /evidence="ECO:0000305"
FT CONFLICT 1804
FT /note="Y -> C (in Ref. 2; AAI50640)"
FT /evidence="ECO:0000305"
FT CONFLICT 1814
FT /note="R -> G (in Ref. 2; AAI50640)"
FT /evidence="ECO:0000305"
FT CONFLICT 1823
FT /note="S -> G (in Ref. 2; AAI50640)"
FT /evidence="ECO:0000305"
FT CONFLICT 1827
FT /note="Q -> R (in Ref. 2; AAI50640)"
FT /evidence="ECO:0000305"
FT CONFLICT 1928
FT /note="K -> R (in Ref. 2; AAI50640)"
FT /evidence="ECO:0000305"
FT CONFLICT 1940
FT /note="I -> V (in Ref. 2; AAI50640)"
FT /evidence="ECO:0000305"
FT CONFLICT 1963
FT /note="K -> R (in Ref. 2; AAI50640)"
FT /evidence="ECO:0000305"
FT CONFLICT 1967
FT /note="T -> A (in Ref. 2; AAI50640)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1969 AA; 219427 MW; B105BD33557F500D CRC64;
MAARSAPSCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYSPR EHRQKFYRGH
SDDIISLALH PERVLVATGQ VGKEPYICIW DSYTVQTISV LKDVHTHGIA CLAFDLDGQR
LVSVGLDSKN AVCVWDWKRG KMLSMAPGHT DRIFDISWDL YQPNKLVSCG VKHIKFWSLC
GNALTPKRGV FGKTGDLQTI LCLACARDEL TYSGALNGDI YVWKGINLIR TIQGAHAAGI
FSMNACEEGF ATGGRDGCIR LWDLTFKPIT VIDLRETDQG YKGLSVRSVC WRGDHILVGT
QDSEIFEIVV QERNKPFLIM QGHCEGELWA LAVHPTKPLA VTGSDDRSVR IWSLVDHALI
ARCNMEEPIR CAAVNADGIH LALGMKDGSF TVLRVRDMTE VVHIKDRKEA IHELKYSPDG
TYLAVGCNDS SVDIYGVAQR YKKVGECLGS LSFITHLDWS SDSRYLQTND GNGKRLFYRM
PGGKEVTSTE EIKGVHWASW TCVSGLEVNG IWPKYSDIND INSVDGNYIG QVLVTADDYG
IIKLFRYPCL RKGAKFRKYI GHSAHVTNVR WSHDYQWVIS IGGADHSVFQ WKFIPERKLK
DAVHIAPQES LADSHSDESD SDLSDVPELD SEIEQETQLT YRRQVYKEDL PQLKEQCKEK
QKSATSKRRE RAPGNSIRLH FVHGYRGYDC RSNLFYTQIG EIVYHVAAVG VIYNRQQNTQ
RFYLGHDDDI LCLTIHPLKD YVATGQVGRD PSIHIWDTET IKPLSILKGH HQYGVSAVDF
SADGKRLASV GIDDSHTVVL WDWKKGEKLS IARGSKDKIF VVKMNPYVPD KLITAGIKHM
KFWRKAGGGL IGRKGYIGTL GKNDTMMCAV YGWTEEMAFS GTSTGDVCIW RDIFLVKTVK
AHDGPVFSMH ALEKGFVTGG KDGIVALWDD SFERCLKTYA IKRAALAPGS KGLLLEDNPS
IRAISLGHGH ILVGTKNGEI LEVDKSGPIT LLVQGHMEGE VWGLATHPYL PICATVSDDK
TLRIWDLSPS HCMLAVRKLK KGGRCCCFSP DGKALAVGLN DGSFLMANAD TLEDLVSFHH
RKDMISDIRF SPGSGKYLAV ASHDSFIDIY NVMSSKRVGI CKGATSYITH IDWDIRGKLL
QVNTGAKEQL FFEAPRGKKQ TIPSVEVEKI AWASWTSVLG LCCEGIWPVI GEVTDVTASC
LTSDKMVLAT GDDLGFVKLF RYPTKGKFGK FKRYVAHSTH VTNVRWTYDD SMLVTLGGTD
MSLMVWTNEM EGYREKRPCD SEESDIDSEE DGGYDSDVTR ENEISYTIRA LSTNIRPMLG
IKPHLQQKEP SIDERPPVSR APPQPEKLQT NNVGKKKRPI EDLVLELIFG YRGRDCRNNV
HYLNDGDDII YHTASVGILH NVATGSQSFY QEHNDDILCL TVNQHPKFIN IVATGQVGDS
ADMSATAPSI HIWDAMNKQT LSILRCYHSK GVCSVSFSAT GKLLLSVGLD PEHTITIWRW
QEGAKIASRA GHNQRIFVAE FRPDSDTQFV SVGVKHVKFW TLAGRALLSK KGLLSTLEDA
RMQTMLAIAF GANNLTFTGT ISGDVCVWKD HILCRIVARA HNGPVFAMYT TLRDGLIVTG
GKERPSKEGG AVKLWDQELR RCRAFRLETG QATDCVRSVC RGKGKILVGT RNAEIIEVGE
KNAACNILVN GHVDGPIWGL ATHPSRDFFL SAAEDGTVRL WDIADKKMLN KVNLGHAART
VCYSPEGDMV AIGMKNGEFI ILLVSSLKIW GKKRDRRCAI HDIRFSPDSR YLAVGSSENS
VDFYDLTLGP TLNRISYCKD IPSFVIQMDF SADSSYLQVS SGCYKRHVYE VPSGKHLMDH
AAIDRITWAT WTSILGDEVL GIWSRHAEKA DVNCACVSHS GISLVTGDDF GMVKLFDFPC
PEKFAKHKRF LGHSPHVTNI RFTSGDRHVV SAGGDDCSLF VWKCVHTPH
