EMAL5_MOUSE
ID EMAL5_MOUSE Reviewed; 1977 AA.
AC Q8BQM8; Q8BRL0; Q8R2W0;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Echinoderm microtubule-associated protein-like 5;
DE Short=EMAP-5;
GN Name=Eml5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-488 AND 1648-1977.
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, and Corpus striatum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1668-1977.
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC31743.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC33148.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC159193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK044024; BAC31743.1; ALT_INIT; mRNA.
DR EMBL; AK047762; BAC33148.1; ALT_INIT; mRNA.
DR EMBL; BC027154; AAH27154.1; -; mRNA.
DR CCDS; CCDS36519.1; -.
DR RefSeq; NP_001074660.1; NM_001081191.1.
DR AlphaFoldDB; Q8BQM8; -.
DR SMR; Q8BQM8; -.
DR STRING; 10090.ENSMUSP00000065643; -.
DR iPTMnet; Q8BQM8; -.
DR PhosphoSitePlus; Q8BQM8; -.
DR MaxQB; Q8BQM8; -.
DR PaxDb; Q8BQM8; -.
DR PRIDE; Q8BQM8; -.
DR ProteomicsDB; 277831; -.
DR Antibodypedia; 47387; 37 antibodies from 16 providers.
DR Ensembl; ENSMUST00000223282; ENSMUSP00000152709; ENSMUSG00000051166.
DR GeneID; 319670; -.
DR KEGG; mmu:319670; -.
DR UCSC; uc007orn.1; mouse.
DR CTD; 161436; -.
DR MGI; MGI:2442513; Eml5.
DR VEuPathDB; HostDB:ENSMUSG00000051166; -.
DR eggNOG; KOG2106; Eukaryota.
DR GeneTree; ENSGT00940000156613; -.
DR HOGENOM; CLU_001930_0_0_1; -.
DR InParanoid; Q8BQM8; -.
DR OMA; LVQWATW; -.
DR OrthoDB; 97584at2759; -.
DR PhylomeDB; Q8BQM8; -.
DR TreeFam; TF317832; -.
DR BioGRID-ORCS; 319670; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Eml5; mouse.
DR PRO; PR:Q8BQM8; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8BQM8; protein.
DR Bgee; ENSMUSG00000051166; Expressed in retinal neural layer and 238 other tissues.
DR ExpressionAtlas; Q8BQM8; baseline and differential.
DR Genevisible; Q8BQM8; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 6.
DR InterPro; IPR024977; Apc4_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12894; ANAPC4_WD40; 2.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 8.
DR SMART; SM00320; WD40; 29.
DR SUPFAM; SSF50978; SSF50978; 4.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 6.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Microtubule; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..1977
FT /note="Echinoderm microtubule-associated protein-like 5"
FT /id="PRO_0000284396"
FT REPEAT 59..100
FT /note="WD 1"
FT REPEAT 104..145
FT /note="WD 2"
FT REPEAT 148..187
FT /note="WD 3"
FT REPEAT 195..233
FT /note="WD 4"
FT REPEAT 235..273
FT /note="WD 5"
FT REPEAT 280..321
FT /note="WD 6"
FT REPEAT 323..362
FT /note="WD 7"
FT REPEAT 406..445
FT /note="WD 8"
FT REPEAT 449..488
FT /note="WD 9"
FT REPEAT 561..601
FT /note="WD 10"
FT REPEAT 725..766
FT /note="WD 11"
FT REPEAT 770..811
FT /note="WD 12"
FT REPEAT 814..853
FT /note="WD 13"
FT REPEAT 861..900
FT /note="WD 14"
FT REPEAT 901..940
FT /note="WD 15"
FT REPEAT 996..1035
FT /note="WD 16"
FT REPEAT 1038..1077
FT /note="WD 17"
FT REPEAT 1080..1120
FT /note="WD 18"
FT REPEAT 1236..1276
FT /note="WD 19"
FT REPEAT 1420..1471
FT /note="WD 20"
FT REPEAT 1475..1516
FT /note="WD 21"
FT REPEAT 1519..1558
FT /note="WD 22"
FT REPEAT 1568..1606
FT /note="WD 23"
FT REPEAT 1608..1654
FT /note="WD 24"
FT REPEAT 1699..1739
FT /note="WD 25"
FT REPEAT 1741..1782
FT /note="WD 26"
FT REPEAT 1783..1822
FT /note="WD 27"
FT REPEAT 1895..1934
FT /note="WD 28"
FT REPEAT 1940..1977
FT /note="WD 29"
FT REGION 609..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1276..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..629
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 1648..1676
FT /note="RRCRAFRLETGQVTDCVRSVCRGKGKILV -> GDAGPSGLRQDKSQIVFGL
FT CAEAKARYYL (in Ref. 2; BAC31743)"
FT /evidence="ECO:0000305"
FT CONFLICT 1668..1671
FT /note="CRGK -> FVFQ (in Ref. 3; AAH27154)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1977 AA; 220106 MW; 92111219F74E8427 CRC64;
MAARSAPSCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYSPR EHRQKFFRGH
SDDIISLALH PERVLVATGQ VGKEPYICVW DSYTVQTVSV LKDVHTHGIA CLAFDLDGQR
LVSVGLDSKN AVCVWDWKRG RMLSMAPGHT DRIFDISWDL YQPNKLVSCG VKHIKFWSLC
GNALTPKRGV FGKTGDLQTI LCLACARDEL TYSGALNGDI YVWKGINLIR TIQGAHTAGI
FSMNSCEEGF ATGGRDGCIR LWDLTFKPIT VIDLRETEQG YKGLSVRSVC WRGDHILVGT
QDSEIFEIVV HERNKPFLIM QGHCEGELWA LAVHPTKPLA VTGSDDRSVR IWSLVDHALI
ARCNMEEPIR CAAVNVDGIH LALGMKDGSF TVLRVRDMTE VVHIKDRKEA IHELKYSPDG
AYLAVGCNDS SVDIYGVAQR YKKVGECVGS LSFITHLDWS SDSRYLQTND GSGKRLLYKM
PGGKEVTSKE EIKGMHWASW TCVAGLEVNG IWPKYSDIND INSVDGNYVG QVLVTADDYG
VVKLFRYPCL RKGAKFRKYI GHSAHVTNVR WSHDYQWVIS IGGADHSVFQ WKFIPERKLK
DALHIAPQES LAESNSDESD SDLSDVPELD SEIEQETQLT YHRQVYKEDL PQLKEQCKEK
QKSATSKRRE RTPGTSIRLH FIHGYRGYDC RSNLFYTQIG EIVYHVAAVG VIYNRQQNTQ
RFYLGHDDDI LCLAIHPLKD YVATGQVGRD PSIHVWDTET IKPLSILKGY HQYGICAVDF
SADGKRLASV GIDDSHTIVL WDWKKGEKLS VTRGSKDKIF VVKMNPYVPD KLITAGIKHM
KFWRRAGGGL IGKKGYVGTL GKNDTMMCAV YGWTEEMAFS GTSTGDVCIW RDVFLVKTVK
AHDGPVFSMH ALEKGFVTGG KDGMVALWDD SFERCLKTYA IKRADLAPGS KGLLLEDNPS
IRAISLGHGH ILVGTKNGEI LEVDKSGPIT LLVQGHMEGE VWGLATHPYL PICATVSDDK
TLRIWDLSPS HCMLAVRKLK KGGRCCCFSP DGKALAVGLN DGSFLMANAD TLEDLVSFHH
RKDIISDIRF SPGSGKYLAV ASHDSFVDIY NVTSSKRVGV CKGATSYITH IDWDSRGKLL
QVNTGAKEQL FFEAPRGKRQ TIPSVEVEKI SWATWTSVLG LCCEGIWPVI GEVTEVTASC
LTSDKMVLAT GDDLGFVKLF RYPAKGKFGK FKKYVAHSTH VTNVRWTYDD SMLVTLGGAD
MSLMVWTNEV ESHREKKYCD SEESDIDSEE DGGYDSDVTR ENEISYTIRA LSTNIRPMFG
VKPHLQQKEP SVDERQGVVR GSRPPVSRAP PQPEKLQSNN VGKKKRPIED LVLELAFGYR
GRDCRNNVHY LNDGDDIIYH TASIGILHNV ATGTQSFYQE HNDDILCLTV NQHPKFINIV
ATGQVGDSAD MSATAPSVHI WDAVNKQTLS ILRCSHSKGV CSVSFSATGK LLLSVGLDPE
HTVTIWRWQE GAKIASRGGH NQRIFVAEFR PDSDTQFVSV GIKHVKFWTL AGRALLSKKG
LLSSLEDARM QTMLAVAFGA NNLTFTGTIS GDVCVWKDHI LCRVVARAHN GPVFAMYTTL
RDGLIVTGGK ERPSKEGGAV KLWDQELRRC RAFRLETGQV TDCVRSVCRG KGKILVGTRN
SEIIEVGEKN AACNILVNGH VDGPIWGLAT HPSRDFFLSA AEDGTVRLWD IADKKMLNKV
NLGHAARTVC YSPEGDMVAI GMKNGEFIIL LVSSLKIWGK KRDRRCAIHD IRFSPDSRYL
AVGSSENSVD FYDLTLGPTL NRISYCKDIP SFVIQMDFSA DSRHLQVSSG CYKRHVYEVP
SGKHLVDHAA IDRITWATWT SILGDEVMGI WSRHAEKADV TCACVSHSGI SLVTGDDFGM
VKLYDFPCPE KFAKHKRFLG HSPHVTNIRF TSGDRHVVSA GGDDCSLFVW KCVHMPH
