EMAL6_HUMAN
ID EMAL6_HUMAN Reviewed; 1958 AA.
AC Q6ZMW3; A8MUB5; B6ZDG7;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Echinoderm microtubule-associated protein-like 6;
DE Short=EMAP-6;
DE AltName: Full=Echinoderm microtubule-associated protein-like 5-like;
GN Name=EML6; Synonyms=EML5L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1455-1958 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZMW3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZMW3-2; Sequence=VSP_034221;
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family. {ECO:0000305}.
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DR EMBL; AC013414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK131467; BAD18612.1; -; mRNA.
DR CCDS; CCDS46286.1; -. [Q6ZMW3-1]
DR RefSeq; NP_001034842.2; NM_001039753.2. [Q6ZMW3-1]
DR AlphaFoldDB; Q6ZMW3; -.
DR SMR; Q6ZMW3; -.
DR BioGRID; 134838; 6.
DR IntAct; Q6ZMW3; 4.
DR STRING; 9606.ENSP00000348842; -.
DR iPTMnet; Q6ZMW3; -.
DR PhosphoSitePlus; Q6ZMW3; -.
DR BioMuta; EML6; -.
DR DMDM; 190358904; -.
DR EPD; Q6ZMW3; -.
DR jPOST; Q6ZMW3; -.
DR MassIVE; Q6ZMW3; -.
DR MaxQB; Q6ZMW3; -.
DR PaxDb; Q6ZMW3; -.
DR PeptideAtlas; Q6ZMW3; -.
DR PRIDE; Q6ZMW3; -.
DR ProteomicsDB; 67929; -. [Q6ZMW3-1]
DR ProteomicsDB; 67930; -. [Q6ZMW3-2]
DR Antibodypedia; 74753; 8 antibodies from 4 providers.
DR Ensembl; ENST00000356458.8; ENSP00000348842.6; ENSG00000214595.13. [Q6ZMW3-1]
DR GeneID; 400954; -.
DR KEGG; hsa:400954; -.
DR MANE-Select; ENST00000356458.8; ENSP00000348842.6; NM_001039753.4; NP_001034842.2.
DR UCSC; uc002ryb.5; human. [Q6ZMW3-1]
DR CTD; 400954; -.
DR DisGeNET; 400954; -.
DR GeneCards; EML6; -.
DR HGNC; HGNC:35412; EML6.
DR HPA; ENSG00000214595; Tissue enhanced (lymphoid tissue, retina).
DR neXtProt; NX_Q6ZMW3; -.
DR OpenTargets; ENSG00000214595; -.
DR PharmGKB; PA164719036; -.
DR VEuPathDB; HostDB:ENSG00000214595; -.
DR eggNOG; KOG2106; Eukaryota.
DR GeneTree; ENSGT00940000155564; -.
DR HOGENOM; CLU_001930_0_0_1; -.
DR InParanoid; Q6ZMW3; -.
DR OMA; DYTTKMY; -.
DR OrthoDB; 97584at2759; -.
DR PhylomeDB; Q6ZMW3; -.
DR TreeFam; TF317832; -.
DR PathwayCommons; Q6ZMW3; -.
DR SignaLink; Q6ZMW3; -.
DR BioGRID-ORCS; 400954; 12 hits in 1070 CRISPR screens.
DR ChiTaRS; EML6; human.
DR GenomeRNAi; 400954; -.
DR Pharos; Q6ZMW3; Tdark.
DR PRO; PR:Q6ZMW3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q6ZMW3; protein.
DR Bgee; ENSG00000214595; Expressed in middle temporal gyrus and 160 other tissues.
DR ExpressionAtlas; Q6ZMW3; baseline and differential.
DR Genevisible; Q6ZMW3; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 6.
DR InterPro; IPR024977; Apc4_WD40_dom.
DR InterPro; IPR011048; Haem_d1_sf.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12894; ANAPC4_WD40; 2.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 9.
DR SMART; SM00320; WD40; 30.
DR SUPFAM; SSF50978; SSF50978; 2.
DR SUPFAM; SSF50998; SSF50998; 2.
DR SUPFAM; SSF51004; SSF51004; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Microtubule;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1958
FT /note="Echinoderm microtubule-associated protein-like 6"
FT /id="PRO_0000325976"
FT REPEAT 59..100
FT /note="WD 1"
FT REPEAT 104..145
FT /note="WD 2"
FT REPEAT 148..187
FT /note="WD 3"
FT REPEAT 195..233
FT /note="WD 4"
FT REPEAT 235..273
FT /note="WD 5"
FT REPEAT 280..321
FT /note="WD 6"
FT REPEAT 323..362
FT /note="WD 7"
FT REPEAT 364..403
FT /note="WD 8"
FT REPEAT 406..445
FT /note="WD 9"
FT REPEAT 561..601
FT /note="WD 10"
FT REPEAT 725..766
FT /note="WD 11"
FT REPEAT 770..811
FT /note="WD 12"
FT REPEAT 814..853
FT /note="WD 13"
FT REPEAT 861..900
FT /note="WD 14"
FT REPEAT 901..940
FT /note="WD 15"
FT REPEAT 996..1035
FT /note="WD 16"
FT REPEAT 1038..1077
FT /note="WD 17"
FT REPEAT 1080..1120
FT /note="WD 18"
FT REPEAT 1191..1230
FT /note="WD 19"
FT REPEAT 1236..1276
FT /note="WD 20"
FT REPEAT 1412..1456
FT /note="WD 21"
FT REPEAT 1460..1501
FT /note="WD 22"
FT REPEAT 1504..1543
FT /note="WD 23"
FT REPEAT 1553..1591
FT /note="WD 24"
FT REPEAT 1593..1638
FT /note="WD 25"
FT REPEAT 1685..1724
FT /note="WD 26"
FT REPEAT 1726..1767
FT /note="WD 27"
FT REPEAT 1768..1807
FT /note="WD 28"
FT REPEAT 1880..1919
FT /note="WD 29"
FT REPEAT 1925..1958
FT /note="WD 30"
FT REGION 603..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1832..1958
FT /note="VSTGAYKRQVHEVPLGKQVTEAVVIEKITWASWTSVLGDEVIGIWPRNADKA
FT DVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKYV
FT VSTGGDDCSVFVWRCL -> MQLTLLVGNHTQRTAILGLWKIARKWMRRKMGKWPAVVV
FT MGWP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034221"
FT CONFLICT 1828
FT /note="K -> Y (in Ref. 2; BAD18612)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1958 AA; 217899 MW; 0A634ACFE1CDF891 CRC64;
MADRTAPRCQ LRLEWVYGYR GHQCRNNLYY TAGKEVVYFV AGVGVVYNTR EHSQKFFLGH
NDDIISLALH PDKTLVATGQ VGKEPYICIW DSYNVQTVSL LKDVHTHGVA CLAFDSDGQR
LASVGLDAKN TVCIWDWRKG KLLASATGHS DRIFDISWDP YQPNRVVSCG VKHIKFWTLC
GNALTAKRGI FGKTGDLQTI LCLACAKEDI TYSGALNGDI YVWKGLNLVR TIQGAHSAGI
FSMYACEEGF ATGGRDGCIR LWDTDFKPIT KIDLRETEQG YKGLSIRSVC WKADRLLAGT
QDSEIFEVIV RERDKPMLIL QGHCEGELWA LALHPKKPLA VTGSDDRSVR LWSLADHALI
ARCNMEEAVR SVAFSPDGSQ LALGMKDGSF IVLRVRDMTE VVHIKDRKEV IHEMKFSPDG
SYLAVGSNDG PVDVYAVAQR YKKIGECSKS LSFITHIDWS LDSKYLQTND GAGERLFYRM
PSGKPLTSKE EIKGIPWASW TCVKGPEVSG IWPKYTEVTD INSVDANYNS SVLVSGDDFG
LVKLFKFPCL KRGAKFRKYV GHSAHVTNVR WSHDFQWVLS TGGADHSVFQ WRFIPEGVSN
GMLETAPQEG GADSYSEESD SDLSDVPELD SDIEQEAQIN YDRQVYKEDL PQLKQQSKEK
NHAVPFLKRE KAPEDSLKLQ FIHGYRGYDC RNNLFYTQAG EVVYHIAAVA VVYNRQQHSQ
RLYLGHDDDI LSLTIHPVKD YVATGQVGRD AAIHVWDTQT LKCLSLLKGQ HQRGVCALDF
SADGKCLVSV GLDDFHSIVF WDWKKGEKIA TTRGHKDKIF VVKCNPHHVD KLVTVGIKHI
KFWQQAGGGF TSKRGTFGSV GKLETMMCVS YGRMEDLVFS GAATGDIFIW KDILLLKTVK
AHDGPVFAMY ALDKGFVTGG KDGIVELWDD MFERCLKTYA IKRSALSTSS KGLLLEDNPS
IRAITLGHGH ILVGTKNGEI LEIDKSGPMT LLVQGHMEGE VWGLAAHPLL PICATVSDDK
TLRIWELSAQ HRMLAVRKLK KGGRCCAFSP DGKALAVGLN DGSFLVVNAD TVEDMVSFHH
RKEMISDIKF SKDTGKYLAV ASHDNFVDIY NVLTSKRVGI CKGASSYITH IDWDSRGKLL
QVNSGAREQL FFEAPRGKRH IIRPSEIEKI EWDTWTCVLG PTCEGIWPAH SDITDVNAAS
LTKDCSLLAT GDDFGFVKLF SYPVKGQHAR FKKYVGHSAH VTNVRWLHND SVLLTVGGAD
TALMIWTREF VGTQESKLVD SEESDTDVEE DGGYDSDVAR EKAIDYTTKI YAVSIREMEG
TKPHQQLKEV SVEERPPVSR AAPQPEKLQK NNITKKKKLV EELALDHVFG YRGFDCRNNL
HYLNDGADII FHTAAAGIVQ NLSTGSQSFY LEHTDDILCL TVNQHPKYRN VVATSQIGTT
PSIHIWDAMT KHTLSMLRCF HSKGVNYINF SATGKLLVSV GVDPEHTITV WRWQEGAKVA
SRGGHLERIF VVEFRPDSDT QFVSVGVKHM KFWTLAGSAL LYKKGVIGSL GAAKMQTMLS
VAFGANNLTF TGAINGDVYV WKDHFLIRLV AKAHTGPVFT MYTTLRDGLI VTGGKERPTK
EGGAVKLWDQ EMKRCRAFQL ETGQLVECVR SVCRGKGKIL VGTKDGEIIE VGEKNAASNI
LIDGHMEGEI WGLATHPSKD LFISASNDGT ARIWDLADKK LLNKVSLGHA ARCAAYSPDG
EMVAIGMKNG EFVILLVNSL KVWGKKRDRK SAIQDIRISP DNRFLAVGSS EHTVDFYDLT
QGTNLNRIGY CKDIPSFVIQ MDFSADGKYI QVSTGAYKRQ VHEVPLGKQV TEAVVIEKIT
WASWTSVLGD EVIGIWPRNA DKADVNCACV THAGLNIVTG DDFGLVKLFD FPCTEKFAKH
KRYFGHSAHV TNIRFSYDDK YVVSTGGDDC SVFVWRCL
