EMAL6_MOUSE
ID EMAL6_MOUSE Reviewed; 1958 AA.
AC Q5SQM0; Q8C4R3; Q8C7L3; Q8R1E3;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Echinoderm microtubule-associated protein-like 6;
DE Short=EMAP-6;
DE AltName: Full=Echinoderm microtubule-associated protein-like 5-like;
GN Name=Eml6; Synonyms=Eml5l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-657 AND 1662-1958.
RC STRAIN=C57BL/6J; TISSUE=Embryonic head, and Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1335-1958.
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH24726.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC38214.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL731792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929371; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX005100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK049977; BAC34015.1; -; mRNA.
DR EMBL; AK081418; BAC38214.1; ALT_INIT; mRNA.
DR EMBL; BC024726; AAH24726.1; ALT_INIT; mRNA.
DR RefSeq; NP_666128.2; NM_146016.2.
DR AlphaFoldDB; Q5SQM0; -.
DR SMR; Q5SQM0; -.
DR BioGRID; 231896; 1.
DR STRING; 10090.ENSMUSP00000051080; -.
DR iPTMnet; Q5SQM0; -.
DR PhosphoSitePlus; Q5SQM0; -.
DR SwissPalm; Q5SQM0; -.
DR MaxQB; Q5SQM0; -.
DR PaxDb; Q5SQM0; -.
DR PRIDE; Q5SQM0; -.
DR ProteomicsDB; 277582; -.
DR Antibodypedia; 74753; 8 antibodies from 4 providers.
DR DNASU; 237711; -.
DR Ensembl; ENSMUST00000058902; ENSMUSP00000051080; ENSMUSG00000044072.
DR GeneID; 237711; -.
DR KEGG; mmu:237711; -.
DR UCSC; uc007ihq.1; mouse.
DR CTD; 400954; -.
DR MGI; MGI:2442895; Eml6.
DR VEuPathDB; HostDB:ENSMUSG00000044072; -.
DR eggNOG; KOG2106; Eukaryota.
DR GeneTree; ENSGT00940000155564; -.
DR HOGENOM; CLU_001930_0_0_1; -.
DR InParanoid; Q5SQM0; -.
DR OMA; DYTTKMY; -.
DR OrthoDB; 97584at2759; -.
DR PhylomeDB; Q5SQM0; -.
DR TreeFam; TF317832; -.
DR BioGRID-ORCS; 237711; 1 hit in 66 CRISPR screens.
DR ChiTaRS; Eml6; mouse.
DR PRO; PR:Q5SQM0; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5SQM0; protein.
DR Bgee; ENSMUSG00000044072; Expressed in spermatid and 116 other tissues.
DR ExpressionAtlas; Q5SQM0; baseline and differential.
DR Genevisible; Q5SQM0; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 6.
DR InterPro; IPR024977; Apc4_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12894; ANAPC4_WD40; 2.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 10.
DR SMART; SM00320; WD40; 30.
DR SUPFAM; SSF50978; SSF50978; 4.
DR SUPFAM; SSF50998; SSF50998; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 6.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Microtubule; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..1958
FT /note="Echinoderm microtubule-associated protein-like 6"
FT /id="PRO_0000284398"
FT REPEAT 59..100
FT /note="WD 1"
FT REPEAT 104..145
FT /note="WD 2"
FT REPEAT 148..187
FT /note="WD 3"
FT REPEAT 195..233
FT /note="WD 4"
FT REPEAT 235..273
FT /note="WD 5"
FT REPEAT 280..321
FT /note="WD 6"
FT REPEAT 323..362
FT /note="WD 7"
FT REPEAT 364..403
FT /note="WD 8"
FT REPEAT 406..445
FT /note="WD 9"
FT REPEAT 561..601
FT /note="WD 10"
FT REPEAT 725..766
FT /note="WD 11"
FT REPEAT 770..811
FT /note="WD 12"
FT REPEAT 814..853
FT /note="WD 13"
FT REPEAT 861..900
FT /note="WD 14"
FT REPEAT 901..940
FT /note="WD 15"
FT REPEAT 996..1035
FT /note="WD 16"
FT REPEAT 1038..1077
FT /note="WD 17"
FT REPEAT 1080..1120
FT /note="WD 18"
FT REPEAT 1191..1230
FT /note="WD 19"
FT REPEAT 1236..1276
FT /note="WD 20"
FT REPEAT 1412..1456
FT /note="WD 21"
FT REPEAT 1460..1501
FT /note="WD 22"
FT REPEAT 1504..1543
FT /note="WD 23"
FT REPEAT 1553..1591
FT /note="WD 24"
FT REPEAT 1593..1638
FT /note="WD 25"
FT REPEAT 1685..1724
FT /note="WD 26"
FT REPEAT 1726..1767
FT /note="WD 27"
FT REPEAT 1768..1807
FT /note="WD 28"
FT REPEAT 1880..1919
FT /note="WD 29"
FT REPEAT 1925..1958
FT /note="WD 30"
FT REGION 604..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 1890
FT /note="V -> M (in Ref. 2; BAC38214)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1958 AA; 217941 MW; 89CFE27D378AA656 CRC64;
MADRTAPRCQ LRLEWVYGYR GHQCRNNLYY TAGKEVVYFV AGVGVVYNTR EHSQKFFLGH
NDDIISLALH PDKTLIATGQ VGKEPYICIW NSYNVHTVSI LKDVHTHGVA CLAFDSDGQH
LASVGLDAKN TVCIWDWRKG KLLASATGHS DRIFDISWDP YQPNRMVSCG VKHIKFWTLC
GNALTAKRGI FGKTGDLQTI LCLACAKEDI TYSGALNGDI YVWKGLTLVR TIQGAHSAGI
FSLYACEEGF ATGGRDGCIR LWDTDFKPIT KIDLRETEQG YKGLSIRSVC WKADRLLAGT
QDSEIFEVIV RERDKPMLIL QGHCEGELWA LALHPKKPLA VTGSDDRSVR LWSLADHALI
ARCNMEEAVR SVSFSPDGSQ LALGMKDGSF IVLRVRDMTE VVHIKDRKEV IHEMKFSPDG
SYLAVGSNDG PVDVYAVAQR YKKIGECNKS LSFITHIDWS LDSKYLQTND GAGERLFYKM
PSGKPLTSKE EIKGIPWASW TCVRGPEVSG IWPKYTEVID INSVDANYNS SVLVSGDDFG
LVKLFKFPCL KKGAKFRKYV GHSAHVTNVR WSHDFQWVLS TGGADHSVFQ WRFIPEAVSN
GVLETTPQEG GADSYSEESD SDFSDVPELD SDIEQETQIN YDRQVYKEDL PQLKQQSKEK
NHAVPFLKRE KAPEDSLKLQ FIHGYRGYDC RNNLFYTQAG EVVYHIAAVA VVYNRQQHAQ
RLYLGHDDDI LSLTIHPVKD YVATGQVGRD AAVHVWDTQT LKCLSLLKGH HQRGVCALDF
SADGKCLVSV GLDDFHSVVF WDWKKGEKIA TTRGHKDKIF VVKCNPQHAD KLVTVGIKHI
KFWQQAGGGF TSKRGSFGSA GKLETMMCVS YGRMEDLVFS GAATGDIFIW KDVLLLKTVK
AHDGPVFAMY ALDKGFVTGG KDGIVELWDD MFERCLKTYA IKRTALSTSS KGLLLEDNPS
IRAITLGHGH ILVGTKNGEI LEIDKSGPMT LLVQGHMEGE VWGLAAHPLL PICATVSDDK
TLRIWELSSQ HRMLAVRKLK KGGRCCAFSP DGKALAVGLN DGSFLVVNAD TVEDMLSFHH
RKEMISDIKF SKDTGKYLAV ASHDNFVDIY NVLTSKRVGI CKGASSYITH IDWDSRGKLL
QVNSGAKEQL FFEAPRGRKH TIRPSEAEKI EWDTWTCVLG PTCEGIWPAH SDVTDVNAAN
LTKDGSLLAT GDDFGFVKLF SYPVKGQHAR FKKYVGHSAH VTNVRWLHND SVLLTVGGAD
TALMIWTREF VGTQESKLVD SEESDTDAEE DGGYDSDVAR EKAIDYTTKI YAVSIREMEG
TKPHQQLKEV SMEERPPVSR AAPQPEKLQK NNITKKKKLV EELALDHVFG YRGFDCRNNL
HYLNDGADII FHTAAAGIVQ NLSTGSQSFY LEHTDDILCL TVNQHPKYRN VVATSQIGTT
PSIHIWDAMT KHTLSMLRCF HTKGVNYINF SATGKLLVSV GVDPEHTITV WRWQEGTKVA
SRGGHLERIF VVEFRPDSDT QFVSVGVKHM KFWTLAGSAL LYKKGVIGSM EAAKMQTMLS
VAFGANNLTF TGAINGDVYV WKEHFLIRLV AKAHTGPVFT MYTTLRDGLI VTGGKERPTK
EGGAVKLWDQ EMKRCRAFQL ETGQLVECVR SVCRGKGKIL VGTKDGEIIE VGEKSAASNI
LIDGHMEGEI WGLATHPSKD MFISASNDGT ARIWDLADKK LLNKVNLGHA ARCAAYSPDG
EMVAIGMKNG EFVILLVNTL KVWGKKRDRK SAIQDIRISP DNRFLAVGSS EQTVDFYDLT
QGTSLNRIGY CKDIPSFVIQ MDFSADSKYI QVSTGAYKRQ VHEVPLGKQV TEAMVVEKIT
WASWTSVLGD EVIGIWPRNA DKADVNCACV THAGLNIVTG DDFGLLKLFD FPCTEKFAKH
KRYFGHSAHV TNIRFSSDDK YVVSTGGDDC SVFVWRCL
