ID   EMAL_CAEEL              Reviewed;         891 AA.
AC   O45487;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Echinoderm microtubule-associated protein-like elp-1;
GN   Name=elp-1; ORFNames=F38A6.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC       microtubules are slightly longer, but more dynamic. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the WD repeat EMAP family. {ECO:0000305}.
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DR   EMBL; Z92833; CAB07379.1; -; Genomic_DNA.
DR   PIR; T21942; T21942.
DR   RefSeq; NP_001256950.1; NM_001270021.1.
DR   AlphaFoldDB; O45487; -.
DR   SMR; O45487; -.
DR   STRING; 6239.F38A6.2a; -.
DR   PaxDb; O45487; -.
DR   EnsemblMetazoa; F38A6.2a.1; F38A6.2a.1; WBGene00001248.
DR   GeneID; 180358; -.
DR   KEGG; cel:CELE_F38A6.2; -.
DR   UCSC; F38A6.2; c. elegans.
DR   CTD; 180358; -.
DR   WormBase; F38A6.2a; CE15999; WBGene00001248; elp-1.
DR   eggNOG; KOG2106; Eukaryota.
DR   HOGENOM; CLU_011754_2_0_1; -.
DR   InParanoid; O45487; -.
DR   OMA; FSVCVMK; -.
DR   OrthoDB; 271572at2759; -.
DR   PhylomeDB; O45487; -.
DR   PRO; PR:O45487; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00001248; Expressed in larva and 3 other tissues.
DR   ExpressionAtlas; O45487; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030425; C:dendrite; IDA:WormBase.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031594; C:neuromuscular junction; IDA:WormBase.
DR   GO; GO:0043025; C:neuronal cell body; IDA:WormBase.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   Pfam; PF03451; HELP; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 9.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Microtubule; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..891
FT                   /note="Echinoderm microtubule-associated protein-like elp-
FT                   1"
FT                   /id="PRO_0000050966"
FT   REPEAT          330..401
FT                   /note="WD 1"
FT   REPEAT          404..447
FT                   /note="WD 2"
FT   REPEAT          499..537
FT                   /note="WD 3"
FT   REPEAT          541..579
FT                   /note="WD 4"
FT   REPEAT          626..664
FT                   /note="WD 5"
FT   REPEAT          708..747
FT                   /note="WD 6"
FT   REPEAT          753..792
FT                   /note="WD 7"
FT   REPEAT          816..853
FT                   /note="WD 8"
FT   REPEAT          859..890
FT                   /note="WD 9"
FT   REGION          77..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..133
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   891 AA;  98372 MW;  A8EFC84FA6FCE852 CRC64;
     MSISNGWSSS SIISDVLPEE EFEEVEEDEL ILNENDRLKF RVDELEKIVV AQRNEILLLQ
     SSTVEILRRL QNLEIQDQSR SPTCSGYSSL PRRISGSKSS YTMSPSHAPP RSSHANSKSL
     YINGMNNNSE EVSPGPPRHR PPTRGSDGMV NVSVGKSARG SPMRKWVSTH DMKDTDRFRR
     LSTSSEASTS ATMNPIVNSV RRLSTTHRQS SPSLLSLCSV ISRSPSTSSI LRKNNRTCQF
     SNGSGHLPIF IGGKTVQVPV PTGYENMDPT MDQDPPTMKV TLKHVYSYRG KDVRSNIEML
     PTGELVFFSA NLVVLMNITG EDRSQRIYHG HTCDVKCITL HPNKILVASG QSSCHSVEKF
     QKPEHTSPID SPEDLVRQLE MEHTEAHVRI WDTIKLTTLM VLNGFEKGIC HVAFSKTDSG
     SLLAVVDDSL KHLMSVWNWQ KGKREGEVKA SNDVVFECKW HPTIRNLIVL YGKGHFSFFN
     YDPATGVLVK TVATFEGRDK PKTVLSMCFG ENDQVVTGDS NGTISIWDPR TCKTTKQAHS
     VHPGGVYSLT LAKSGKILSG GKDRMVSEWD LQDLVRTRRP IELPDEKGFP RVILQNGSEL
     IIGTSSNTLL FGNIENSTNL TSLIEGDPGN LTFLLTCSSN QLITSSQCGT LRIWNHIDKK
     VEFSKKFIDS VECVDVDVTN THIILGFAAG LWIVMNITKQ QTIQEKKEGT APITAVKFAP
     SGATFAVATK DPHLTIYRID ASKNLLVIAR IHHIPAPIVA LDFSSDSQYL RGQSIGAHLL
     FWTKAGEICD GTSVKDVKWG SSRVKIGFET ALVAHSSNGQ VTAVAQCEDI SACGMENGTI
     RIYKNPVTSV TAGFVELLGH GRIIKSVAFS NKIQLFSCSP TDNSVFEWCL E