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EMAL_DROME
ID   EMAL_DROME              Reviewed;        1076 AA.
AC   Q9VUI3; A4IJ53; Q8IGY9; Q9NII4; Q9VUI2;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 3.
DT   03-AUG-2022, entry version 164.
DE   RecName: Full=Echinoderm microtubule-associated protein-like CG42247;
GN   Name=DCX-EMAP; ORFNames=CG42247;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D).
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
RC   STRAIN=Berkeley;
RA   Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA   Celniker S.E.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 931-1076.
RX   PubMed=10603347; DOI=10.1242/dev.127.2.291;
RA   Lai E.C., Bodner R., Kavaler J., Freschi G., Posakony J.W.;
RT   "Antagonism of Notch signaling activity by members of a novel protein
RT   family encoded by the Bearded and Enhancer of split gene complexes.";
RL   Development 127:291-306(2000).
CC   -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC       microtubules are slightly longer, but more dynamic. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=C;
CC         IsoId=Q9VUI3-1; Sequence=Displayed;
CC       Name=D;
CC         IsoId=Q9VUI3-2; Sequence=VSP_035862;
CC   -!- SIMILARITY: Belongs to the WD repeat EMAP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF33205.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AE014296; AAF49697.2; -; Genomic_DNA.
DR   EMBL; AE014296; AAF49698.2; -; Genomic_DNA.
DR   EMBL; BT001524; AAN71279.1; -; mRNA.
DR   EMBL; BT030411; ABO52831.1; -; mRNA.
DR   EMBL; AF208486; AAF33205.1; ALT_FRAME; Genomic_DNA.
DR   RefSeq; NP_648728.2; NM_140471.3. [Q9VUI3-1]
DR   RefSeq; NP_648729.1; NM_140472.2. [Q9VUI3-2]
DR   AlphaFoldDB; Q9VUI3; -.
DR   SMR; Q9VUI3; -.
DR   BioGRID; 64942; 12.
DR   IntAct; Q9VUI3; 1.
DR   STRING; 7227.FBpp0288783; -.
DR   PaxDb; Q9VUI3; -.
DR   DNASU; 39617; -.
DR   EnsemblMetazoa; FBtr0299509; FBpp0288783; FBgn0259099. [Q9VUI3-1]
DR   EnsemblMetazoa; FBtr0299510; FBpp0288784; FBgn0259099. [Q9VUI3-2]
DR   GeneID; 39617; -.
DR   KEGG; dme:Dmel_CG42247; -.
DR   UCSC; CG42247-RC; d. melanogaster.
DR   CTD; 39617; -.
DR   FlyBase; FBgn0259099; DCX-EMAP.
DR   VEuPathDB; VectorBase:FBgn0259099; -.
DR   eggNOG; KOG2106; Eukaryota.
DR   eggNOG; KOG3757; Eukaryota.
DR   InParanoid; Q9VUI3; -.
DR   PhylomeDB; Q9VUI3; -.
DR   Reactome; R-DME-9648025; EML4 and NUDC in mitotic spindle formation.
DR   BioGRID-ORCS; 39617; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 39617; -.
DR   PRO; PR:Q9VUI3; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0259099; Expressed in antenna and 16 other tissues.
DR   ExpressionAtlas; Q9VUI3; baseline and differential.
DR   Genevisible; Q9VUI3; DM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0071683; C:sensory dendrite; IDA:FlyBase.
DR   GO; GO:0008017; F:microtubule binding; IDA:FlyBase.
DR   GO; GO:0008344; P:adult locomotory behavior; IMP:FlyBase.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0035011; P:melanotic encapsulation of foreign target; IMP:FlyBase.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007605; P:sensory perception of sound; IMP:FlyBase.
DR   Gene3D; 2.130.10.10; -; 2.
DR   Gene3D; 3.10.20.230; -; 2.
DR   InterPro; IPR003533; Doublecortin_dom.
DR   InterPro; IPR036572; Doublecortin_dom_sf.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF03607; DCX; 1.
DR   Pfam; PF03451; HELP; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00537; DCX; 2.
DR   SMART; SM00320; WD40; 9.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   SUPFAM; SSF89837; SSF89837; 2.
DR   PROSITE; PS50309; DC; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Cytoskeleton; Microtubule;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1076
FT                   /note="Echinoderm microtubule-associated protein-like
FT                   CG42247"
FT                   /id="PRO_0000050967"
FT   DOMAIN          171..253
FT                   /note="Doublecortin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT   DOMAIN          300..384
FT                   /note="Doublecortin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00072"
FT   REPEAT          525..571
FT                   /note="WD 1"
FT   REPEAT          576..621
FT                   /note="WD 2"
FT   REPEAT          623..661
FT                   /note="WD 3"
FT   REPEAT          668..706
FT                   /note="WD 4"
FT   REPEAT          712..751
FT                   /note="WD 5"
FT   REPEAT          801..840
FT                   /note="WD 6"
FT   REPEAT          842..878
FT                   /note="WD 7"
FT   REPEAT          881..920
FT                   /note="WD 8"
FT   REPEAT          926..965
FT                   /note="WD 9"
FT   REPEAT          996..1035
FT                   /note="WD 10"
FT   REPEAT          1041..1076
FT                   /note="WD 11"
FT   REGION          1..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..143
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..257
FT                   /note="Missing (in isoform D)"
FT                   /evidence="ECO:0000303|PubMed:12537569"
FT                   /id="VSP_035862"
FT   CONFLICT        837
FT                   /note="W -> L (in Ref. 3; AAN71279)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        865
FT                   /note="L -> P (in Ref. 3; AAN71279)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        961
FT                   /note="S -> V (in Ref. 5; AAF33205)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1076 AA;  119255 MW;  35AA50B66565B6D9 CRC64;
     MPQISPNAPL EGNVSPPPTQ PHLDDNLHNG NGNGNGIHSS SSNINKHGSN INGNNDSNRS
     SPAKSPKRPV SSSFRIQNTS RYDNDEEDLA ASEQVAGGDR QVPDYWQQRN GATTGATSGR
     QSRAISPGYL DNMSENSEQP PVVPLVRSKS RPEISSAAAS RYNNLSYWKA RRVVFYRNGD
     PFFPGVELRY RPGRDVTSLD NLLDKISPKM DLPRGARYVF SMDGDRKYHL DELEDGAFYV
     VSSFKAFKPA SYGKKNGMWY ASPGNQGWGS KPASRKPSIM EADLGTLSTT SGSIKRSAGR
     VIRIINNLDH SVQCRVLLNL RTSQPFEEVL EDLGQVLKIN GAKKMYTGTG QEVRSFSQLR
     NEFADVDTFY LATGTALIAG SPIRRSRSRP SVVAAAPILP TDELPKVPLR GARPRSKSRP
     RILYAPESEI LRPNGEYTML DIMKEEPTKV TIRGLRRTFY PPVHHAPADN SPPDKKLQLQ
     WVHGYRGIDA RRNLWVLPSG ELLYYVAAVA VLFDRDEDAQ RHYTGHTEDI MCMDVHPSRE
     LVASGQKAGR DRKSQAHVRI WSTESLQTLY VFGMGELDSG VTAVAFSQLN GGSYILAVDS
     GRESILSVWQ WQWGHLLGKV ATLQEGLSGA AFHPLDDNLI ITHGRGHLAF WHRRKDGFFE
     RTDIVKQPSR SHVTSVQFEP DGDVITADSD GFITIYSVDS DGAYFVRTEF EAHNKGIGCL
     IMLGEGTLLS GGEKDRKIAA WDSLQNYKKI ADTKLPEAAG GVRTIYPQRP GRNDGNIYVG
     TTRNNILEGS LQRRFTQVVF GHGRQLWGLA AHPDDELYAT AGHDKHVALW RKNKLIWTIQ
     TGYECVALAF HPFGTLAAGS TEGHLLVINC ENGAVMLTLR VCGSPLNCVA YNQVGDMIAM
     GSQNGSIYLF RVSRDGFSYK KVNKIRGSQP LTHLDWSMDG NFVQTVTIDF DLLFWDAKSL
     SPERSPIAMK DVKWLTNNCT VGFLVAGQWS NRYYSTTNTI VATCSRSAAH DMLASGDAEG
     YLRLFRYPCI SPRAEFHESK VYSGMLACVR FLCGDHTLIT VGGTDASLMV WDIVEE
 
 
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