ID   EMAP_LYTVA              Reviewed;         664 AA.
AC   Q9Y1C1;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=77 kDa echinoderm microtubule-associated protein;
DE   Flags: Fragment;
GN   Name=EMAP;
OS   Lytechinus variegatus (Green sea urchin) (Echinus variegatus).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Temnopleuroida; Toxopneustidae; Lytechinus.
OX   NCBI_TaxID=7654;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10603080; DOI=10.1007/pl00008183;
RA   Suprenant K.A., Tuxhorn J.A., Daggett M.A.F., Ahrens D.P., Hostetler A.,
RA   Palange J.M., VanWinkle C.E., Livingston B.T.;
RT   "Conservation of the WD-repeat, microtubule-binding protein, EMAP, in sea
RT   urchins, humans, and the nematode C. elegans.";
RL   Dev. Genes Evol. 210:2-10(2000).
CC   -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC       microtubules are slightly longer, but more dynamic.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the WD repeat EMAP family. {ECO:0000305}.
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DR   EMBL; AF136234; AAD44709.1; -; mRNA.
DR   AlphaFoldDB; Q9Y1C1; -.
DR   SMR; Q9Y1C1; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR011044; Quino_amine_DH_bsu.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   Pfam; PF03451; HELP; 1.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50969; SSF50969; 1.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Repeat; WD repeat.
FT   CHAIN           <1..664
FT                   /note="77 kDa echinoderm microtubule-associated protein"
FT                   /id="PRO_0000050965"
FT   REPEAT          120..167
FT                   /note="WD 1"
FT   REPEAT          172..215
FT                   /note="WD 2"
FT   REPEAT          218..257
FT                   /note="WD 3"
FT   REPEAT          265..303
FT                   /note="WD 4"
FT   REPEAT          307..346
FT                   /note="WD 5"
FT   REPEAT          390..429
FT                   /note="WD 6"
FT   REPEAT          473..512
FT                   /note="WD 7"
FT   REPEAT          519..558
FT                   /note="WD 8"
FT   REPEAT          631..663
FT                   /note="WD 9"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   664 AA;  73423 MW;  6F5E000E66707E78 CRC64;
     DGRPRTSPRG GSASGKRFQK EPQHNAASHS TYNQEEGYVR IYLRGRPVTN YLPSDVEDYD
     INAKHPAPTE KLKLDWVYGY RGRDCRCNLY LLPTGEIVYF MAAVVILYNV EEQNQRHYMG
     HNDDVKSIAV HPDSVTIATG QVAGHDAAEG KPHVRIWSSI TLETLHVIGL GFFDRAVCSL
     SFSKVNVGVN LAAVDESNEH VLSLWDWKKE KKICDTKSSQ DPVLACEFHP MNDEQIITLG
     KGHIHFWNTA GGKLVKKSGI FEKYDKPKFM LSLAFTGNGD VITGDSNGNM YIWGKGNTRI
     SQAVLGAHEG GIFSLCVMND GQILSGGGKD KKVVLWTADY QQSETTQVPE ATGPVRTLCK
     GKGENFYVGT TRNAILSGDM GGDFTTLVQA HTEELWGLAL HPTQGMFLTC GYDKNVILWD
     FEQHTQRWNK FMEDGCQSAG FHPSGEVVAI GMTSGRWVAL DVESGDLYTV HTDGKEQHDI
     IRYSPNGEYL AVASHDNYIY IYSVKETGRK YSKVGRCSGH SSFVTHIDWS ADSTKLQSNS
     GDYELLFWDA ETCKQIVGSK ETRDIEWATF TGVLGYPVCG IWPEGSDGTD VNTTARSGNG
     NILATGDDFG KISLFRYPVN HPKADCNSFK GHSSHVTSVA FNEDSTKLIS TGGRDMSCMQ
     WSVV