ID   EMAP_STRPU              Reviewed;         686 AA.
AC   Q26613;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=77 kDa echinoderm microtubule-associated protein;
GN   Name=EMAP;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7989351; DOI=10.1016/s0021-9258(18)31763-0;
RA   Li Q., Suprenant K.A.;
RT   "Molecular characterization of the 77-kDa echinoderm microtubule-associated
RT   protein. Homology to the beta-transducin family.";
RL   J. Biol. Chem. 269:31777-31784(1994).
CC   -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC       microtubules are slightly longer, but more dynamic.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the WD repeat EMAP family. {ECO:0000305}.
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DR   EMBL; U15551; AAA61945.1; -; mRNA.
DR   PIR; A55665; A55665.
DR   RefSeq; NP_999633.1; NM_214468.1.
DR   AlphaFoldDB; Q26613; -.
DR   SMR; Q26613; -.
DR   STRING; 7668.SPU_005744-tr; -.
DR   EnsemblMetazoa; NM_214468; NP_999633; GeneID_373186.
DR   GeneID; 373186; -.
DR   KEGG; spu:373186; -.
DR   CTD; 373186; -.
DR   eggNOG; KOG2106; Eukaryota.
DR   HOGENOM; CLU_011754_3_2_1; -.
DR   InParanoid; Q26613; -.
DR   OMA; TTRDIQW; -.
DR   OrthoDB; 271572at2759; -.
DR   PhylomeDB; Q26613; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR011044; Quino_amine_DH_bsu.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   Pfam; PF03451; HELP; 1.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 9.
DR   SUPFAM; SSF50969; SSF50969; 1.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..686
FT                   /note="77 kDa echinoderm microtubule-associated protein"
FT                   /id="PRO_0000050964"
FT   REPEAT          142..189
FT                   /note="WD 1"
FT   REPEAT          194..237
FT                   /note="WD 2"
FT   REPEAT          240..279
FT                   /note="WD 3"
FT   REPEAT          287..325
FT                   /note="WD 4"
FT   REPEAT          329..368
FT                   /note="WD 5"
FT   REPEAT          412..451
FT                   /note="WD 6"
FT   REPEAT          495..534
FT                   /note="WD 7"
FT   REPEAT          541..580
FT                   /note="WD 8"
FT   REPEAT          608..647
FT                   /note="WD 9"
FT   REPEAT          653..685
FT                   /note="WD 10"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   686 AA;  75454 MW;  F692A011309E07AC CRC64;
     MSNRPSTARP NSASPRRPNT PGRPSSARPG SGRTRASPRG GSAGGKRFSK EPQHNAEEGY
     VRIYLRGRPV TNYLPSDVED YDLNAKHPAP TEKLKLDWVY GYRGRDCRCN LYLLPTGEII
     YFMAAVVVLY NVEEQNQRHY TGHNDDVKSI AVHPDSVTIA TGQVAGHDPD EGKPHVRIWN
     SITMETLHVL GLGFFDRAVC ALSFSKVNVG VHLAAVDESN EHVLSVWDWK KEKKLSDTKS
     SQDPVLACEY HPMNDEQIIT LGKGHIHFWN TTGGKLVKKS GIFEKYDKPK FVLSLAFTGN
     GDVITGDSNG NMYIWGKGNT RISQAILGAH EGGIFSLCVM NDGQILSGGG KDKKVILWTA
     DYQQSEVTQV TEATGPVRTL CKGKGEDFYV GTTRNAILSG NMGGEFNTLV QAHTEELWGL
     ALHPTQGLFL TCGYDKNVIM WDFEQHKPMW NKLMEDGCQS AGFHPSGAVV AIGMTSGRWV
     ALDVESQDLI TVHTDGKEQH DIIRYSPDGN FLAVASHDNY IYIYSVTEEG RKYSKVGKCS
     GHSSFVTHID WSADSTKLQS NSGDYELLFW DAATCKQIVI SKETRDVEWA TFTGVLGYPV
     CGIWPEGSDG TDVNTTARSA NGNLLASGDD FGKINLFRYP VNHPKADCTS FKGHSSHVTS
     VAFNGDSTKL ISTGGRDMSC MQWSVV