ID   EMARD_MACFA             Reviewed;         668 AA.
AC   Q4R6F2;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Endoplasmic reticulum membrane-associated RNA degradation protein;
DE            Short=ER membrane-associated RNA degradation protein;
DE   Flags: Fragment;
GN   Name=ERMARD; ORFNames=QtsA-18153;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in neuronal migration during embryonic
CC       development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
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DR   EMBL; AB169231; BAE01323.1; -; mRNA.
DR   AlphaFoldDB; Q4R6F2; -.
DR   STRING; 9541.XP_005551438.1; -.
DR   PRIDE; Q4R6F2; -.
DR   eggNOG; ENOG502QS21; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR025209; DUF4209.
DR   InterPro; IPR039635; ERMARD.
DR   PANTHER; PTHR31701; PTHR31701; 1.
DR   Pfam; PF13910; DUF4209; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           <1..668
FT                   /note="Endoplasmic reticulum membrane-associated RNA
FT                   degradation protein"
FT                   /id="PRO_0000295627"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        575..595
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   668 AA;  76525 MW;  4ABD299A5F1DD827 CRC64;
     VLIGDPITTC LSPSVYDIIC NLGFQLRENC DINSIVTQNG EVCWKTITDC VSYTESDQGL
     DYWGSVRLLG PVCEAVHSHF LSLTKGQFEI RYAPWFQWTS FPELFPEIFD ALESLQSPAI
     SLSLMKLTSC LERALGDVFL LIGKECPFLL RDLLASEELA QVFGQSVMNV LKVFVGSPCG
     LNLRNVLWHG FASPEEVPPK YCSMMMLLTA GLGQLLKSYL QKTKLTLAHR SFITPTNLED
     LIVFPDVTYE VLSVLEEAMT KSAFILKIML PYWEVALVKF KSHRFADCAI LLLTQLETGL
     RNVFATLNRC PQRLLTAEIL AKHLNDGKIN QLPLFLGEPA MEFLWDFLNH QEGPRIRDHL
     SHGEINLHEF SKETTNQLLA FSVVLLLRFV DEGLLSVFKE KASVELLISL AEGYSSRCHP
     VFQLKKQVLS CEESIRVWAL LPFPKELTWE AVRLEDNSET NACHSLITKM TDELYHHMPE
     DHCVLKDLDH LPTETWPQLL HELCSTPVRT LFCPRIVLEV LVVLRSIGKQ CHRVSGQVTI
     ASELRHRQWV ERTLRSRQRQ NYLRMWSSIR LLSPVLSLIL FLITLELVNV HAVCGKNAHE
     YQQYLKFVKS ILQYTENLVA YTSYEKNKWN ETINLTHTVL LKIWTFSEKK QMLIHLAKKS
     TSKVLMKT