EMBA_MYCBO
ID EMBA_MYCBO Reviewed; 1094 AA.
AC P0A561; A0A1R3Y589; P72029; P72060; X2BPU8;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Probable arabinosyltransferase A;
DE EC=2.4.2.-;
GN Name=embA; OrderedLocusNames=BQ2027_MB3823;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- FUNCTION: Arabinosyl transferase responsible for the polymerization of
CC arabinose into the arabinan of arabinogalactan. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the emb family. {ECO:0000305}.
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DR EMBL; LT708304; SIU02452.1; -; Genomic_DNA.
DR RefSeq; NP_857460.1; NC_002945.3.
DR RefSeq; WP_003899696.1; NC_002945.4.
DR AlphaFoldDB; P0A561; -.
DR SMR; P0A561; -.
DR EnsemblBacteria; SIU02452; SIU02452; BQ2027_MB3823.
DR PATRIC; fig|233413.5.peg.4181; -.
DR OMA; GWLHFRM; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052636; F:arabinosyltransferase activity; IEA:InterPro.
DR GO; GO:0071766; P:Actinobacterium-type cell wall biogenesis; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.610; -; 1.
DR Gene3D; 2.60.120.940; -; 1.
DR InterPro; IPR032731; Arabino_trans_C.
DR InterPro; IPR042486; Arabino_trans_C_2.
DR InterPro; IPR007680; Arabino_trans_central.
DR InterPro; IPR040920; Arabino_trans_N.
DR InterPro; IPR027451; EmbABC_dom1.
DR Pfam; PF14896; Arabino_trans_C; 1.
DR Pfam; PF17689; Arabino_trans_N; 1.
DR Pfam; PF04602; Arabinose_trans; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell wall biogenesis/degradation; Glycosyltransferase;
KW Membrane; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..1094
FT /note="Probable arabinosyltransferase A"
FT /id="PRO_0000220561"
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..470
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 519..536
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 543..565
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 575..597
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 604..626
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 641..663
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 684..706
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1094 AA; 115724 MW; 11EEA34999633EEC CRC64;
MPHDGNERSH RIARLAAVVS GIAGLLLCGI VPLLPVNQTT ATIFWPQGST ADGNITQITA
PLVSGAPRAL DISIPCSAIA TLPANGGLVL STLPAGGVDT GKAGLFVRAN QDTVVVAFRD
SVAAVAARST IAAGGCSALH IWADTGGAGA DFMGIPGGAG TLPPEKKPQV GGIFTDLKVG
AQPGLSARVD IDTRFITTPG ALKKAVMLLG VLAVLVAMVG LAALDRLSRG RTLRDWLTRY
RPRVRVGFAS RLADAAVIAT LLLWHVIGAT SSDDGYLLTV ARVAPKAGYV ANYYRYFGTT
EAPFDWYTSV LAQLAAVSTA GVWMRLPATL AGIACWLIVS RFVLRRLGPG PGGLASNRVA
VFTAGAVFLS AWLPFNNGLR PEPLIALGVL VTWVLVERSI ALGRLAPAAV AIIVATLTAT
LAPQGLIALA PLLTGARAIA QRIRRRRATD GLLAPLAVLA AALSLITVVV FRDQTLATVA
ESARIKYKVG PTIAWYQDFL RYYFLTVESN VEGSMSRRFA VLVLLFCLFG VLFVLLRRGR
VAGLASGPAW RLIGTTAVGL LLLTFTPTKW AVQFGAFAGL AGVLGAVTAF TFARIGLHSR
RNLTLYVTAL LFVLAWATSG INGWFYVGNY GVPWYDIQPV IASHPVTSMF LTLSILTGLL
AAWYHFRMDY AGHTEVKDNR RNRILASTPL LVVAVIMVAG EVGSMAKAAV FRYPLYTTAK
ANLTALSTGL SSCAMADDVL AEPDPNAGML QPVPGQAFGP DGPLGGISPV GFKPEGVGED
LKSDPVVSKP GLVNSDASPN KPNAAITDSA GTAGGKGPVG INGSHAALPF GLDPARTPVM
GSYGENNLAA TATSAWYQLP PRSPDRPLVV VSAAGAIWSY KEDGDFIYGQ SLKLQWGVTG
PDGRIQPLGQ VFPIDIGPQP AWRNLRFPLA WAPPEADVAR IVAYDPNLSP EQWFAFTPPR
VPVLESLQRL IGSATPVLMD IATAANFPCQ RPFSEHLGIA ELPQYRILPD HKQTAASSNL
WQSSSTGGPF LFTQALLRTS TIATYLRGDW YRDWGSVEQY HRLVPADQAP DAVVEEGVIT
VPGWGRPGPI RALP
