EMBB_MYCAV
ID EMBB_MYCAV Reviewed; 1065 AA.
AC P71486;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Probable arabinosyltransferase B;
DE EC=2.4.2.-;
GN Name=embB;
OS Mycobacterium avium.
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=1764;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=2151;
RX PubMed=8876238; DOI=10.1073/pnas.93.21.11919;
RA Belanger A.E., Besra G.S., Ford M.E., Mikusova K., Belisle J.T.,
RA Brennan P.J., Inamine J.M.;
RT "The embAB genes of Mycobacterium avium encode an arabinosyl transferase
RT involved in cell wall arabinan biosynthesis that is the target for the
RT antimycobacterial drug ethambutol.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:11919-11924(1996).
CC -!- FUNCTION: Arabinosyl transferase responsible for the polymerization of
CC arabinose into the arabinan of arabinogalactan.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the emb family. {ECO:0000305}.
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DR EMBL; U66560; AAC44548.1; -; Genomic_DNA.
DR AlphaFoldDB; P71486; -.
DR SMR; P71486; -.
DR CAZy; GT53; Glycosyltransferase Family 53.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052636; F:arabinosyltransferase activity; IEA:InterPro.
DR GO; GO:0071766; P:Actinobacterium-type cell wall biogenesis; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.610; -; 1.
DR Gene3D; 2.60.120.940; -; 1.
DR InterPro; IPR032731; Arabino_trans_C.
DR InterPro; IPR042486; Arabino_trans_C_2.
DR InterPro; IPR007680; Arabino_trans_central.
DR InterPro; IPR040920; Arabino_trans_N.
DR InterPro; IPR027451; EmbABC_dom1.
DR Pfam; PF14896; Arabino_trans_C; 1.
DR Pfam; PF17689; Arabino_trans_N; 1.
DR Pfam; PF04602; Arabinose_trans; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Cell membrane; Cell wall biogenesis/degradation;
KW Glycosyltransferase; Membrane; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1065
FT /note="Probable arabinosyltransferase B"
FT /id="PRO_0000220565"
FT TRANSMEM 15..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 510..527
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 540..557
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 567..589
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 596..618
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 633..655
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 667..689
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1065 AA; 114625 MW; 3F12D113678C62BF CRC64;
MSVSTVGGDV RVTRWVATIA GLIGFVLSVA TPLLPVVQTT ATLNWPQGGQ LNSVTAPLIS
LTPVDLTATV PCSLVRDLPP GGGVILSTGP KKGKDAALNA LFVVAHGKRV DVTDRNVVIA
SASRDQVAGA GCSRIEIAST RAGTFATFVG LTDPAGKPLG GGFPDPNLRP QIVGVFTDLT
GPAPAGLKLS ATIDTRFSTT PTTLKLAAMV TAILATIVAL VALWRLDQLD GHRMRRLIPA
NWRTFTLADV AVIFGFVLWH VIGANSSDDG YILGMARVAD RAGYMSNYFR WFGSPEDPFG
WYYNLLALMT HVSDASLWMR LPDLFAGIVC WLLLSREVLP RLGPAVAASR PANWAAGMVL
LTAWMPFDNG LRPEPIIALG SLVTYVLIER SMRYSRLTPA ALAVITAAFT LGVQPTGLIA
VAALVAGGRP ILRILVRRHR VVGTWPLVAP MLAAGTVILT VVFADQTLAT VLEATRIRTA
IGPSQAWYTE NLRYYYLILP TVDGSLSRRF GFLITALCLF TAVFIMLRRK RIPGVARGPA
WRLMGVIFGT MFFLMFTPTK WVHHFGLFAA VGAAMAALTT VLVSPAVLGW SRNRMAFLAA
LLFMMALCFA TTNGWWYVSS YGVPFNSTMP KIGGITVSTV FFSMFVAAAL YAIWLHFASR
EHGEGRLARA LTAAPVPLAA GFMALVFIAS MVAGIVRQYP TYSNAWDNLR EFSGGCGLAD
DVLVEPDSNV GYMTPLGGDY GPLGPLGGQH PVGFSPNGVP EHTVAEAIRI TPNQPGTDYD
WDAPTKLSAP GINGSTVPLP YGLDAARVPL AGSYTTGAQQ QSRLTSAWYR LPAPDDGHPL
VVVTAAGKIA GNSVLHHHTD GQTVVLEYGR PGPGGDIVPA GRLVPYDLYG EQPKAWRNLR
FARSDMPADT VAVRVVAEDL SLTPEDWIAV TPPRVPEMRS LQEYVGSTQP VLMDWAVGLA
FPCQQPMLHV NGVTEIPKFR ITPDYTAKKM DTDTWEDGTN GGLLGITDLL LRAHVMSTYL
SHDWGRDWGS LRRFETIADA HPAQLDLGTA TRTGWWSPGP IRIKP