ID   EMBP2_CAVPO             Reviewed;         234 AA.
AC   P35709;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Eosinophil granule major basic protein 2;
DE            Short=MBP-2;
DE   Flags: Precursor;
GN   Name=MBP2;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Eosinophil;
RX   PubMed=2026266; DOI=10.1016/0014-5793(91)80443-7;
RA   Aoki I., Shindoh Y., Nishida T., Nakai S., Hong Y.-M., Mio M., Saito T.,
RA   Tasaka K.;
RT   "Comparison of the amino acid and nucleotide sequences between human and
RT   two guinea pig major basic proteins.";
RL   FEBS Lett. 282:56-60(1991).
CC   -!- FUNCTION: MBP may play some important roles in the allergic reactions
CC       and inflammations, since MBP is capable of releasing histamine from
CC       mast cells and damaging the epithelial cells of bronchial tubes.
CC       Antiparasitic and antibiotic.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Matrix of eosinophil's
CC       large specific granule (crystalloid core).
CC   -!- PTM: Nitrated. {ECO:0000250}.
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DR   EMBL; D00817; BAA00697.1; -; mRNA.
DR   PIR; S15102; S15102.
DR   RefSeq; NP_001166350.1; NM_001172879.1.
DR   AlphaFoldDB; P35709; -.
DR   SMR; P35709; -.
DR   STRING; 10141.ENSCPOP00000015284; -.
DR   MEROPS; I63.001; -.
DR   GeneID; 100379574; -.
DR   KEGG; cpoc:100379574; -.
DR   CTD; 100379574; -.
DR   eggNOG; KOG4297; Eukaryota.
DR   InParanoid; P35709; -.
DR   OrthoDB; 1328472at2759; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd03598; CLECT_EMBP_like; 1.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR018378; C-type_lectin_CS.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR033816; EMBP_CTLD.
DR   InterPro; IPR002352; Eosinophil_major_basic.
DR   Pfam; PF00059; Lectin_C; 1.
DR   PRINTS; PR00770; EMAJORBASICP.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW   Glycoprotein; Immunity; Lectin; Nitration; Proteoglycan;
KW   Reference proteome; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   PROPEP          16..115
FT                   /note="Acidic"
FT                   /id="PRO_0000017381"
FT   CHAIN           116..234
FT                   /note="Eosinophil granule major basic protein 2"
FT                   /id="PRO_0000017382"
FT   DOMAIN          133..234
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   REGION          26..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..86
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        69
FT                   /note="O-linked (Xyl...) (glycosaminoglycan) serine"
FT                   /evidence="ECO:0000250"
FT   DISULFID        135..232
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        209..224
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ   SEQUENCE   234 AA;  26140 MW;  7D926A942BF5116F CRC64;
     MKLLLLLALL VGAVSTRHLN VDTSSLQSLQ GEESLAQDGE TAEGATREAA SGVLMPLREE
     VKEEMEGGSG SEDDPEEEEE EKEMESSSEL DMGPEDVQCP KEEDIVKFEG SPGCKICRYV
     VLSVPKTFKQ AQSVCQRCFR GNLASIHSYN INLQVQRSSR ILNVAQVWIG GQLRGKGHHK
     HFHWVDGTLW NFWYWAAGQP WRGNNSGRCV TLCARGGHWR RSHCGVRRAF SCSY