ID   EMC10_BOVIN             Reviewed;         262 AA.
AC   A1A4M2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=ER membrane protein complex subunit 10;
DE   Flags: Precursor;
GN   Name=EMC10; Synonyms=INM02;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex, and Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the endoplasmic reticulum membrane protein complex
CC       (EMC) that enables the energy-independent insertion into endoplasmic
CC       reticulum membranes of newly synthesized membrane proteins.
CC       Preferentially accommodates proteins with transmembrane domains that
CC       are weakly hydrophobic or contain destabilizing features such as
CC       charged and aromatic residues. Involved in the cotranslational
CC       insertion of multi-pass membrane proteins in which stop-transfer
CC       membrane-anchor sequences become ER membrane spanning helices. It is
CC       also required for the post-translational insertion of tail-anchored/TA
CC       proteins in endoplasmic reticulum membranes. By mediating the proper
CC       cotranslational insertion of N-terminal transmembrane domains in an N-
CC       exo topology, with translocated N-terminus in the lumen of the ER,
CC       controls the topology of multi-pass membrane proteins like the G
CC       protein-coupled receptors. By regulating the insertion of various
CC       proteins in membranes, it is indirectly involved in many cellular
CC       processes. Promotes angiogenesis and tissue repair in the heart after
CC       myocardial infarction. Stimulates cardiac endothelial cell migration
CC       and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling
CC       pathways. {ECO:0000250|UniProtKB:Q5UCC4}.
CC   -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC       {ECO:0000250|UniProtKB:Q5UCC4}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q5UCC4}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:Q5UCC4}.
CC   -!- SIMILARITY: Belongs to the EMC10 family. {ECO:0000305}.
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DR   EMBL; BC123856; AAI23857.1; -; mRNA.
DR   EMBL; BC126720; AAI26721.1; -; mRNA.
DR   RefSeq; NP_001073708.1; NM_001080239.1.
DR   AlphaFoldDB; A1A4M2; -.
DR   SMR; A1A4M2; -.
DR   STRING; 9913.ENSBTAP00000054183; -.
DR   PaxDb; A1A4M2; -.
DR   PRIDE; A1A4M2; -.
DR   Ensembl; ENSBTAT00000064928; ENSBTAP00000054183; ENSBTAG00000045510.
DR   GeneID; 507692; -.
DR   KEGG; bta:507692; -.
DR   CTD; 284361; -.
DR   VEuPathDB; HostDB:ENSBTAG00000045510; -.
DR   VGNC; VGNC:28462; EMC10.
DR   eggNOG; KOG4827; Eukaryota.
DR   GeneTree; ENSGT00390000004520; -.
DR   HOGENOM; CLU_065716_0_0_1; -.
DR   InParanoid; A1A4M2; -.
DR   OMA; QFNDVLW; -.
DR   OrthoDB; 1514526at2759; -.
DR   TreeFam; TF314052; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000045510; Expressed in midbrain and 105 other tissues.
DR   ExpressionAtlas; A1A4M2; baseline and differential.
DR   GO; GO:0072546; C:EMC complex; ISS:UniProtKB.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:Ensembl.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
DR   GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
DR   GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.
DR   GO; GO:1900745; P:positive regulation of p38MAPK cascade; ISS:UniProtKB.
DR   GO; GO:0045050; P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence; ISS:UniProtKB.
DR   GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; ISS:UniProtKB.
DR   InterPro; IPR029615; Emc10.
DR   PANTHER; PTHR21397:SF4; PTHR21397:SF4; 1.
PE   2: Evidence at transcript level;
KW   Angiogenesis; Endoplasmic reticulum; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250|UniProtKB:Q5UCC4"
FT   CHAIN           26..262
FT                   /note="ER membrane protein complex subunit 10"
FT                   /id="PRO_0000315047"
FT   TOPO_DOM        26..221
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q5UCC4"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        243..262
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q5UCC4"
SQ   SEQUENCE   262 AA;  27425 MW;  0B277E82A0EBAB99 CRC64;
     MSVPAAGATR LLLLLLVAAA TPSRARGSGC RSGAAVRGVG VEGREGEGCG TVGLLLEHSF
     EIDDSAHFRK RGSLLWNQQD GTLSLSQRQL NEEERGRLRD VAALNGLYRV RVPRRPGAPD
     GPEAGGYVSS FVPACSLVES HLSDQLTLHV DVAGNVVGVS VVTYPGGCRG HEVEDVDLEL
     FNTSVQLQPP VTAPGPETAA FIERLEMEQA QKAKNPQEQK SFFAKYWMYI VPVVLFLMMS
     GAPDAGGQGG GGGGGGGGGS GR