ID   EMC10_XENTR             Reviewed;         263 AA.
AC   Q6P7K5; Q28IN8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=ER membrane protein complex subunit 10;
DE   Flags: Precursor;
GN   Name=emc10; ORFNames=TNeu053m17.1, TNeu118a02.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the endoplasmic reticulum membrane protein complex
CC       (EMC) that enables the energy-independent insertion into endoplasmic
CC       reticulum membranes of newly synthesized membrane proteins.
CC       Preferentially accommodates proteins with transmembrane domains that
CC       are weakly hydrophobic or contain destabilizing features such as
CC       charged and aromatic residues. Involved in the cotranslational
CC       insertion of multi-pass membrane proteins in which stop-transfer
CC       membrane-anchor sequences become ER membrane spanning helices. It is
CC       also required for the post-translational insertion of tail-anchored/TA
CC       proteins in endoplasmic reticulum membranes. By mediating the proper
CC       cotranslational insertion of N-terminal transmembrane domains in an N-
CC       exo topology, with translocated N-terminus in the lumen of the ER,
CC       controls the topology of multi-pass membrane proteins like the G
CC       protein-coupled receptors. By regulating the insertion of various
CC       proteins in membranes, it is indirectly involved in many cellular
CC       processes. Promotes angiogenesis and tissue repair in the heart after
CC       myocardial infarction. Stimulates cardiac endothelial cell migration
CC       and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling
CC       pathways. {ECO:0000250|UniProtKB:Q5UCC4}.
CC   -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC       {ECO:0000250|UniProtKB:Q5UCC4}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q5UCC4}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:Q5UCC4}.
CC   -!- SIMILARITY: Belongs to the EMC10 family. {ECO:0000305}.
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DR   EMBL; CR760224; CAJ83041.1; -; mRNA.
DR   EMBL; CR760298; CAJ82859.1; -; mRNA.
DR   EMBL; BC061625; AAH61625.1; -; mRNA.
DR   RefSeq; NP_988902.1; NM_203571.1.
DR   AlphaFoldDB; Q6P7K5; -.
DR   SMR; Q6P7K5; -.
DR   STRING; 8364.ENSXETP00000053654; -.
DR   PaxDb; Q6P7K5; -.
DR   DNASU; 394497; -.
DR   GeneID; 394497; -.
DR   KEGG; xtr:394497; -.
DR   CTD; 284361; -.
DR   Xenbase; XB-GENE-5788294; emc10.
DR   eggNOG; KOG4827; Eukaryota.
DR   HOGENOM; CLU_065716_2_0_1; -.
DR   InParanoid; Q6P7K5; -.
DR   OMA; QFNDVLW; -.
DR   OrthoDB; 1514526at2759; -.
DR   PhylomeDB; Q6P7K5; -.
DR   TreeFam; TF314052; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000024985; Expressed in testis and 16 other tissues.
DR   ExpressionAtlas; Q6P7K5; differential.
DR   GO; GO:0072546; C:EMC complex; ISS:UniProtKB.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR   GO; GO:0045050; P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence; ISS:UniProtKB.
DR   GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; ISS:UniProtKB.
DR   InterPro; IPR029615; Emc10.
DR   PANTHER; PTHR21397:SF4; PTHR21397:SF4; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000250|UniProtKB:Q5UCC4"
FT   CHAIN           35..263
FT                   /note="ER membrane protein complex subunit 10"
FT                   /id="PRO_0000315053"
FT   TOPO_DOM        35..222
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q5UCC4"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        244..263
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q5UCC4"
SQ   SEQUENCE   263 AA;  28399 MW;  08CD1BFB390334E1 CRC64;
     MAAGCLVGQR AGPLSDKLSG YCWVLLPLLL VATAQASVCR LKTGDGRDSE SCGTNLELEH
     SFELDDSIHF KKRGSLIWSG TAEQSISILQ KQLTEDERNK LRDIANLNGL YRIRVPRKLG
     ITEEANEYVT SFVRACSMVE SHLSDQISVH TDISGNVVGI SIVTFPGSCN GAEVEDVDLE
     MFNTTVYIQQ PIAAAVPETA AFIERLEMEQ AQKAKNPQEQ KSFFAKYWMY IIPVVLFLMM
     SGASDAGNQG GNGGGGGGSG GGR