ID   EMC3_YEAS6              Reviewed;         253 AA.
AC   B5VLV9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=ER membrane protein complex subunit 3;
DE   AltName: Full=Altered inheritance rate of mitochondria protein 27;
GN   Name=AIM27; Synonyms=EMC3; ORFNames=AWRI1631_110210;
OS   Saccharomyces cerevisiae (strain AWRI1631) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=545124;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AWRI1631;
RX   PubMed=18778279; DOI=10.1111/j.1567-1364.2008.00434.x;
RA   Borneman A.R., Forgan A.H., Pretorius I.S., Chambers P.J.;
RT   "Comparative genome analysis of a Saccharomyces cerevisiae wine strain.";
RL   FEMS Yeast Res. 8:1185-1195(2008).
CC   -!- FUNCTION: The EMC seems to be required for efficient folding of
CC       proteins in the endoplasmic reticulum (ER). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ER membrane protein complex (EMC), which is
CC       composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EMC3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDZ71080.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; ABSV01001416; EDZ71080.1; ALT_FRAME; Genomic_DNA.
DR   AlphaFoldDB; B5VLV9; -.
DR   SMR; B5VLV9; -.
DR   Proteomes; UP000008988; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR008568; EMC3.
DR   InterPro; IPR002809; EMC3/TMCO1.
DR   PANTHER; PTHR13116; PTHR13116; 1.
DR   Pfam; PF01956; EMC3_TMCO1; 1.
DR   PIRSF; PIRSF010045; DUF850_TM_euk; 1.
DR   SMART; SM01415; DUF106; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..253
FT                   /note="ER membrane protein complex subunit 3"
FT                   /id="PRO_0000377674"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   253 AA;  28321 MW;  C06E803A4651CF1C CRC64;
     MLLDDQLKYW VLLPISIVMV LTGVLKQYIM TLITGSSANE AQPRVKLTEW QYLQWAQLLI
     GNGGNLSSDA FAAKKEFLVK DLTEERHLAK AKQQGGSQAG EVPNPFNDPN MSNAMMNMAK
     GNMASFIPQT IIMWWVNHFF AGFILMQLPF PLTAKFKEML QTGIICQDLD VRWVSSISWY
     FISVLGLNPV YNLIGLNDQD MGIQAGIGGP QGPQGPPQSQ VDKAMHAMAN DLTIIQHETC
     LDNVEQRVLK QYM