EMC5_SCHPO
ID EMC5_SCHPO Reviewed; 106 AA.
AC C6Y4A7;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=ER membrane protein complex subunit 5;
GN Name=emc5; ORFNames=SPAP4C9.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP IDENTIFICATION.
RX PubMed=18488015; DOI=10.1038/nature07002;
RA Wilhelm B.T., Marguerat S., Watt S., Schubert F., Wood V., Goodhead I.,
RA Penkett C.J., Rogers J., Baehler J.;
RT "Dynamic repertoire of a eukaryotic transcriptome surveyed at single-
RT nucleotide resolution.";
RL Nature 453:1239-1243(2008).
CC -!- FUNCTION: The EMC seems to be required for efficient folding of
CC proteins in the endoplasmic reticulum (ER).
CC {ECO:0000250|UniProtKB:P40540}.
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC {ECO:0000250|UniProtKB:P40540}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P40540}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the membrane magnesium transporter (TC 1.A.67)
CC family. {ECO:0000305}.
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DR EMBL; CU329670; CBA11503.1; -; Genomic_DNA.
DR RefSeq; XP_002742512.1; XM_002742466.2.
DR AlphaFoldDB; C6Y4A7; -.
DR STRING; 4896.SPAP4C9.02.1; -.
DR PaxDb; C6Y4A7; -.
DR EnsemblFungi; SPAP4C9.02.1; SPAP4C9.02.1:pep; SPAP4C9.02.
DR PomBase; SPAP4C9.02; emc5.
DR VEuPathDB; FungiDB:SPAP4C9.02; -.
DR HOGENOM; CLU_2224731_0_0_1; -.
DR OMA; IKCEVIL; -.
DR PRO; PR:C6Y4A7; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0072546; C:EMC complex; ISO:PomBase.
DR GO; GO:0045048; P:protein insertion into ER membrane; IC:PomBase.
DR InterPro; IPR018937; MMgT.
DR Pfam; PF10270; MMgT; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..106
FT /note="ER membrane protein complex subunit 5"
FT /id="PRO_0000389151"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..46
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..106
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 106 AA; 12136 MW; E07A1EA96D69FCE6 CRC64;
MESSTINAKK ISVLLTLFSI IGYTAYSAHE SILEIRQDGK LPLDIKCEVI LVTLLFTFTT
VIIASPLRSI QLNKWSHQRS DLAFLNSRTN FLRIKELKEK IEKVKN
