ID   EMC7_XENTR              Reviewed;         237 AA.
AC   Q0IHY5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=ER membrane protein complex subunit 7;
DE   Flags: Precursor;
GN   Name=emc7;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the endoplasmic reticulum membrane protein complex
CC       (EMC) that enables the energy-independent insertion into endoplasmic
CC       reticulum membranes of newly synthesized membrane proteins.
CC       Preferentially accommodates proteins with transmembrane domains that
CC       are weakly hydrophobic or contain destabilizing features such as
CC       charged and aromatic residues. Involved in the cotranslational
CC       insertion of multi-pass membrane proteins in which stop-transfer
CC       membrane-anchor sequences become ER membrane spanning helices. It is
CC       also required for the post-translational insertion of tail-anchored/TA
CC       proteins in endoplasmic reticulum membranes. By mediating the proper
CC       cotranslational insertion of N-terminal transmembrane domains in an N-
CC       exo topology, with translocated N-terminus in the lumen of the ER,
CC       controls the topology of multi-pass membrane proteins like the G
CC       protein-coupled receptors. By regulating the insertion of various
CC       proteins in membranes, it is indirectly involved in many cellular
CC       processes. {ECO:0000250|UniProtKB:Q9NPA0}.
CC   -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC       {ECO:0000250|UniProtKB:Q9NPA0}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9NPA0}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:Q9NPA0}.
CC   -!- SIMILARITY: Belongs to the EMC7 family. {ECO:0000305}.
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DR   EMBL; BC122910; AAI22911.1; -; mRNA.
DR   RefSeq; NP_001072567.1; NM_001079099.1.
DR   AlphaFoldDB; Q0IHY5; -.
DR   SMR; Q0IHY5; -.
DR   STRING; 8364.ENSXETP00000035270; -.
DR   PaxDb; Q0IHY5; -.
DR   DNASU; 780022; -.
DR   GeneID; 780022; -.
DR   KEGG; xtr:780022; -.
DR   CTD; 56851; -.
DR   Xenbase; XB-GENE-945123; emc7.
DR   eggNOG; KOG3306; Eukaryota.
DR   HOGENOM; CLU_073620_1_2_1; -.
DR   InParanoid; Q0IHY5; -.
DR   OrthoDB; 1348328at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0072546; C:EMC complex; ISS:UniProtKB.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR   GO; GO:0045050; P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence; ISS:UniProtKB.
DR   GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; ISS:UniProtKB.
DR   InterPro; IPR039163; EMC7.
DR   InterPro; IPR019008; EMC7_beta_sandwich.
DR   PANTHER; PTHR13605; PTHR13605; 1.
DR   Pfam; PF09430; DUF2012; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..237
FT                   /note="ER membrane protein complex subunit 7"
FT                   /id="PRO_0000300095"
FT   TOPO_DOM        29..156
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NPA0"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        178..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NPA0"
FT   REGION          216..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   237 AA;  26341 MW;  9B2DAC42CE56955A CRC64;
     MPAVALGVSV GWRSLSLWLL ALLQLCSADL DVLSPGSGSD KFKVEGRAVV PGVRPQDWVN
     TARVLVDGEE HVGFLRTDGS FVVHDVPSGS YVVEVISPAH RFEPVRVDIT SKGKMRARYV
     NHIKTSEVVR LPYPLQMKSS GPPSYFIKRE TWGWTDFLMN PMVMMMVLPL LIFVLLPKVV
     NTSDPEMRRE MEQSMNMLNT NPELPDVSEF MTRLFTSKSS SKSSGSGKAG KSVGKRR