EMC8_BOVIN
ID EMC8_BOVIN Reviewed; 210 AA.
AC Q32KL5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=ER membrane protein complex subunit 8;
DE AltName: Full=Neighbor of COX4;
GN Name=EMC8; Synonyms=COX4NB;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the endoplasmic reticulum membrane protein complex
CC (EMC) that enables the energy-independent insertion into endoplasmic
CC reticulum membranes of newly synthesized membrane proteins.
CC Preferentially accommodates proteins with transmembrane domains that
CC are weakly hydrophobic or contain destabilizing features such as
CC charged and aromatic residues. Involved in the cotranslational
CC insertion of multi-pass membrane proteins in which stop-transfer
CC membrane-anchor sequences become ER membrane spanning helices. It is
CC also required for the post-translational insertion of tail-anchored/TA
CC proteins in endoplasmic reticulum membranes. By mediating the proper
CC cotranslational insertion of N-terminal transmembrane domains in an N-
CC exo topology, with translocated N-terminus in the lumen of the ER,
CC controls the topology of multi-pass membrane proteins like the G
CC protein-coupled receptors. By regulating the insertion of various
CC proteins in membranes, it is indirectly involved in many cellular
CC processes. {ECO:0000250|UniProtKB:O43402}.
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC). EMC8 and
CC EMC9 are mutually exclusive subunits of the EMC complex.
CC {ECO:0000250|UniProtKB:O43402}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:O43402}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O43402}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:O43402}.
CC -!- SIMILARITY: Belongs to the EMC8/EMC9 family. {ECO:0000305}.
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DR EMBL; BC110035; AAI10036.1; -; mRNA.
DR RefSeq; NP_001033163.1; NM_001038074.1.
DR AlphaFoldDB; Q32KL5; -.
DR SMR; Q32KL5; -.
DR STRING; 9913.ENSBTAP00000021393; -.
DR PaxDb; Q32KL5; -.
DR PRIDE; Q32KL5; -.
DR GeneID; 510727; -.
DR KEGG; bta:510727; -.
DR CTD; 10328; -.
DR eggNOG; KOG3289; Eukaryota.
DR InParanoid; Q32KL5; -.
DR OrthoDB; 1284861at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0072546; C:EMC complex; ISS:UniProtKB.
DR GO; GO:0045050; P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence; ISS:UniProtKB.
DR GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; ISS:UniProtKB.
DR CDD; cd08060; MPN_UPF0172; 1.
DR InterPro; IPR005366; EMC8/9.
DR InterPro; IPR037518; MPN.
DR PANTHER; PTHR12941; PTHR12941; 1.
DR Pfam; PF03665; UPF0172; 1.
DR PROSITE; PS50249; MPN; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Reference proteome.
FT CHAIN 1..210
FT /note="ER membrane protein complex subunit 8"
FT /id="PRO_0000328439"
FT DOMAIN 4..150
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ SEQUENCE 210 AA; 23777 MW; FF9B1A2E4F4C55E3 CRC64;
MPGVKLTTQA YCKMVLHGAK YPHCAVDGLL VAEKQKPRKE HLPLGGPGAH HTLFVDCIPL
FHGTLALAPM LEVALTLIDS WCKDNSYVIA GYYQANERVK DASPNQVAEK VASRIAEGFS
DTALIMVDNT KFTMDCVVPT IHVYEHHENK WRCRDPHYDY CEDWPEAQRI SASLLDSRSY
ETLVDFDNHL DDIRNDWTNP EINKAVLHLC
