EML2_ARATH
ID EML2_ARATH Reviewed; 313 AA.
AC Q9FG29; Q8LE93;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 04-FEB-2015, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein EMSY-LIKE 2 {ECO:0000303|PubMed:21830950};
DE Short=AtEML2 {ECO:0000303|PubMed:21830950};
GN Name=EML2 {ECO:0000303|PubMed:21830950};
GN OrderedLocusNames=At5g06780 {ECO:0000312|Araport:AT5G06780};
GN ORFNames=MPH15.14 {ECO:0000312|EMBL:BAB09812.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAB09812.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, INDUCTION BY HEAT, INTERACTION WITH EDM2, DISRUPTION PHENOTYPE,
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21830950; DOI=10.1094/mpmi-05-11-0123;
RA Tsuchiya T., Eulgem T.;
RT "EMSY-like genes are required for full RPP7-mediated race-specific immunity
RT and basal defense in Arabidopsis.";
RL Mol. Plant Microbe Interact. 24:1573-1581(2011).
CC -!- FUNCTION: Probably involved in the regulation of chromatin states
CC (Probable). Contributes to RPP7-mediated and basal immunity, especially
CC against Hyaloperonospora arabidopsidis isolate Hiks1. Regulates
CC negatively EDM2-dependent floral transition (PubMed:21830950).
CC {ECO:0000269|PubMed:21830950, ECO:0000305|PubMed:21830950}.
CC -!- SUBUNIT: Interacts with EDM2 in nucleus. {ECO:0000269|PubMed:21830950}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C7C4}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=1;
CC IsoId=Q9FG29-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FG29-2; Sequence=VSP_057384;
CC -!- INDUCTION: Slightly induced by heat stress.
CC {ECO:0000269|PubMed:21830950}.
CC -!- DISRUPTION PHENOTYPE: Reduced resistance to Hyaloperonospora
CC arabidopsidis isolate Hiks1. Slight early flowering phenotype.
CC {ECO:0000269|PubMed:21830950}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP002032; BAB09812.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91064.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91065.1; -; Genomic_DNA.
DR EMBL; AF428436; AAL16205.1; -; mRNA.
DR EMBL; AY125551; AAM78061.1; -; mRNA.
DR EMBL; AY085555; AAM62778.1; -; mRNA.
DR RefSeq; NP_001190242.1; NM_001203313.1. [Q9FG29-1]
DR RefSeq; NP_196296.1; NM_120761.5. [Q9FG29-2]
DR AlphaFoldDB; Q9FG29; -.
DR SMR; Q9FG29; -.
DR IntAct; Q9FG29; 12.
DR STRING; 3702.AT5G06780.1; -.
DR iPTMnet; Q9FG29; -.
DR PaxDb; Q9FG29; -.
DR PRIDE; Q9FG29; -.
DR ProteomicsDB; 222659; -. [Q9FG29-1]
DR EnsemblPlants; AT5G06780.1; AT5G06780.1; AT5G06780. [Q9FG29-2]
DR EnsemblPlants; AT5G06780.2; AT5G06780.2; AT5G06780. [Q9FG29-1]
DR GeneID; 830567; -.
DR Gramene; AT5G06780.1; AT5G06780.1; AT5G06780. [Q9FG29-2]
DR Gramene; AT5G06780.2; AT5G06780.2; AT5G06780. [Q9FG29-1]
DR KEGG; ath:AT5G06780; -.
DR Araport; AT5G06780; -.
DR TAIR; locus:2170179; AT5G06780.
DR eggNOG; KOG4675; Eukaryota.
DR HOGENOM; CLU_038636_0_0_1; -.
DR InParanoid; Q9FG29; -.
DR OMA; VTHYNAV; -.
DR OrthoDB; 620151at2759; -.
DR PRO; PR:Q9FG29; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FG29; baseline and differential.
DR Genevisible; Q9FG29; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0050832; P:defense response to fungus; IMP:UniProtKB.
DR GO; GO:0019048; P:modulation by virus of host process; IDA:TAIR.
DR GO; GO:0009408; P:response to heat; IEP:UniProtKB.
DR GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:UniProtKB.
DR Gene3D; 1.10.1240.40; -; 1.
DR InterPro; IPR014002; Agenet_dom_plant.
DR InterPro; IPR033485; EMSY-LIKE_plant.
DR InterPro; IPR005491; ENT_dom.
DR InterPro; IPR036142; ENT_dom-like_sf.
DR PANTHER; PTHR33432; PTHR33432; 1.
DR Pfam; PF03735; ENT; 1.
DR SMART; SM00743; Agenet; 1.
DR SMART; SM01191; ENT; 1.
DR SUPFAM; SSF158639; SSF158639; 1.
DR PROSITE; PS51138; ENT; 1.
PE 1: Evidence at protein level;
KW Alternative initiation; Coiled coil; Nucleus; Phosphoprotein;
KW Plant defense; Reference proteome.
FT CHAIN 1..313
FT /note="Protein EMSY-LIKE 2"
FT /id="PRO_0000431792"
FT DOMAIN 1..88
FT /note="ENT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00476"
FT REGION 84..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 35..58
FT /evidence="ECO:0000255"
FT COILED 267..293
FT /evidence="ECO:0000255"
FT MOD_RES 294
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:F4K2F0"
FT VAR_SEQ 1
FT /note="M -> MVGLHINM (in isoform 2)"
FT /id="VSP_057384"
SQ SEQUENCE 313 AA; 35586 MW; 59EA3DEDC609C196 CRC64;
MEAQIHILEQ EAYSAVLRAF QAQADEFSWD KATVMTNLRK ELRISDDENR QLLNNVHNDD
LIKRIRDSRP RGGNQVVRHQ SLDVHPSPTF SASRKKQKTF QSYPSIGSTR SKSFNNRVVS
ANEPAEALIG RKVWTKWPED NSFYEAVVTQ YNANEGRHAL VYDINTVNET WEWVDLNEIP
TKDIRWDGEE DGVTLNVGHG GGTTRGNRRT LSHGGRGRGP RTQPRREHLA TENGGGRKFF
GEIELFNTDS LVKEVERVFD SNLPDPHELD KAKKLLKEHE QALIAAIARL TDASDYESDG
EEPYSHELPM LLG
