EMO1_CAEEL
ID EMO1_CAEEL Reviewed; 68 AA.
AC Q19967;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Protein transport protein Sec61 subunit gamma;
GN Name=sec-61.G {ECO:0000312|WormBase:F32D8.6};
GN Synonyms=emo-1 {ECO:0000303|PubMed:8707849, ECO:0000312|WormBase:F32D8.6},
GN oar-1 {ECO:0000312|WormBase:F32D8.6};
GN ORFNames=F32D8.6 {ECO:0000312|WormBase:F32D8.6};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Bristol N2;
RX PubMed=8707849; DOI=10.1083/jcb.134.3.699;
RA Iwasaki K., McCarter J., Francis R., Schedl T.;
RT "emo-1, a Caenorhabditis elegans Sec61p gamma homologue, is required for
RT oocyte development and ovulation.";
RL J. Cell Biol. 134:699-714(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION.
RX PubMed=12533508; DOI=10.1101/gad.1028303;
RA Miller M.A., Ruest P.J., Kosinski M., Hanks S.K., Greenstein D.;
RT "An Eph receptor sperm-sensing control mechanism for oocyte meiotic
RT maturation in Caenorhabditis elegans.";
RL Genes Dev. 17:187-200(2003).
CC -!- FUNCTION: Required for oocyte development and ovulation
CC (PubMed:8707849, PubMed:12533508). Required for the translocation of
CC secretory and transmembrane proteins into the endoplasmic reticulum in
CC vitro (PubMed:8707849). {ECO:0000269|PubMed:12533508,
CC ECO:0000269|PubMed:8707849}.
CC -!- SUBUNIT: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and
CC SEC61-gamma. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Single-pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the germline (PubMed:8707849).
CC Expression in the germline is regulated in a sex- and meiotic cycle
CC stage-specific manner (PubMed:8707849). Expressed in somatic tissues
CC including the intestine and somatic gonad (PubMed:8707849). Expressed
CC in the intestine more highly in hermaprodites than in males
CC (PubMed:8707849). In hermaphrodites, weakly expressed in the
CC spermatheca (PubMed:8707849). {ECO:0000269|PubMed:8707849}.
CC -!- SIMILARITY: Belongs to the SecE/SEC61-gamma family. {ECO:0000305}.
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DR EMBL; U53785; AAC47274.1; -; Genomic_DNA.
DR EMBL; BX284605; CAA98458.1; -; Genomic_DNA.
DR PIR; T21656; T21656.
DR RefSeq; NP_505778.1; NM_073377.5.
DR AlphaFoldDB; Q19967; -.
DR SMR; Q19967; -.
DR BioGRID; 44538; 1.
DR STRING; 6239.F32D8.6; -.
DR EPD; Q19967; -.
DR PaxDb; Q19967; -.
DR PeptideAtlas; Q19967; -.
DR EnsemblMetazoa; F32D8.6.1; F32D8.6.1; WBGene00001303.
DR GeneID; 179510; -.
DR UCSC; F32D8.6.1; c. elegans.
DR CTD; 179510; -.
DR WormBase; F32D8.6; CE05785; WBGene00001303; sec-61.G.
DR eggNOG; KOG3498; Eukaryota.
DR GeneTree; ENSGT00390000001319; -.
DR HOGENOM; CLU_167752_2_0_1; -.
DR InParanoid; Q19967; -.
DR OMA; RDGNQFL; -.
DR OrthoDB; 1623399at2759; -.
DR PhylomeDB; Q19967; -.
DR Reactome; R-CEL-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR PRO; PR:Q19967; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00001303; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005784; C:Sec61 translocon complex; ISS:WormBase.
DR GO; GO:0071261; C:Ssh1 translocon complex; IBA:GO_Central.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015450; F:protein-transporting ATPase activity; ISS:WormBase.
DR GO; GO:0006886; P:intracellular protein transport; TAS:WormBase.
DR GO; GO:0001555; P:oocyte growth; IMP:WormBase.
DR GO; GO:0030728; P:ovulation; IMP:WormBase.
DR GO; GO:0031204; P:post-translational protein targeting to membrane, translocation; IBA:GO_Central.
DR Gene3D; 1.20.5.820; -; 1.
DR HAMAP; MF_00422; SecE; 1.
DR InterPro; IPR023391; Prot_translocase_SecE_dom_sf.
DR InterPro; IPR008158; Translocase_Sec61-g.
DR InterPro; IPR001901; Translocase_SecE/Sec61-g.
DR Pfam; PF00584; SecE; 1.
DR SUPFAM; SSF103456; SSF103456; 1.
DR TIGRFAMs; TIGR00327; secE_euk_arch; 1.
DR PROSITE; PS01067; SECE_SEC61G; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Endoplasmic reticulum; Membrane;
KW Oogenesis; Protein transport; Reference proteome; Translocation;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..68
FT /note="Protein transport protein Sec61 subunit gamma"
FT /id="PRO_0000104200"
FT TOPO_DOM 1..32
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..68
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 68 AA; 7761 MW; A35DB3740B6ED2C4 CRC64;
MDQFQALIEP ARQFSKDSYR LVKRCTKPDR KEYQKIAMAT AIGFAIMGFI GFFVKLIHIP
INNIIVGA
