EMP1_MOUSE
ID EMP1_MOUSE Reviewed; 160 AA.
AC P47801;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Epithelial membrane protein 1;
DE Short=EMP-1;
DE AltName: Full=Tumor-associated membrane protein;
GN Name=Emp1; Synonyms=Tmp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain tumor;
RX PubMed=8996089; DOI=10.1016/s0378-1119(96)00475-1;
RA Ben-Porath I., Benvenisty N.;
RT "Characterization of a tumor-associated gene, a member of a novel family of
RT genes encoding membrane glycoproteins.";
RL Gene 183:69-75(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129/Sv, and BDF1; TISSUE=Intestine;
RX PubMed=8884260; DOI=10.1006/geno.1996.0482;
RA Lobsiger C., Magyar J.P., Taylor V., Wulf P., Welcher A.A., Suter U.;
RT "Identification and characterization of a cDNA and the structural gene
RT encoding the mouse epithelial membrane protein-1.";
RL Genomics 36:379-387(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-35.
RC TISSUE=Myoblast;
RX PubMed=19656770; DOI=10.1074/mcp.m900195-mcp200;
RA Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D.,
RA Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.;
RT "The mouse C2C12 myoblast cell surface N-linked glycoproteome:
RT identification, glycosite occupancy, and membrane orientation.";
RL Mol. Cell. Proteomics 8:2555-2569(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U25633; AAC52968.1; -; mRNA.
DR EMBL; X98403; CAA67053.1; -; mRNA.
DR EMBL; X98471; CAA67106.1; -; Genomic_DNA.
DR EMBL; BC046299; AAH46299.1; -; mRNA.
DR EMBL; BC050899; AAH50899.1; -; mRNA.
DR CCDS; CCDS20647.1; -.
DR PIR; JC5730; JC5730.
DR RefSeq; NP_001275556.1; NM_001288627.1.
DR RefSeq; NP_001275557.1; NM_001288628.1.
DR RefSeq; NP_034258.1; NM_010128.4.
DR RefSeq; XP_006505565.1; XM_006505502.1.
DR AlphaFoldDB; P47801; -.
DR SMR; P47801; -.
DR IntAct; P47801; 1.
DR STRING; 10090.ENSMUSP00000107538; -.
DR GlyGen; P47801; 3 sites.
DR iPTMnet; P47801; -.
DR PhosphoSitePlus; P47801; -.
DR PaxDb; P47801; -.
DR PeptideAtlas; P47801; -.
DR PRIDE; P47801; -.
DR ProteomicsDB; 277861; -.
DR Antibodypedia; 23604; 116 antibodies from 19 providers.
DR DNASU; 13730; -.
DR Ensembl; ENSMUST00000032330; ENSMUSP00000032330; ENSMUSG00000030208.
DR Ensembl; ENSMUST00000111907; ENSMUSP00000107538; ENSMUSG00000030208.
DR Ensembl; ENSMUST00000205156; ENSMUSP00000145069; ENSMUSG00000030208.
DR GeneID; 13730; -.
DR KEGG; mmu:13730; -.
DR UCSC; uc009elo.1; mouse.
DR CTD; 2012; -.
DR MGI; MGI:107941; Emp1.
DR VEuPathDB; HostDB:ENSMUSG00000030208; -.
DR eggNOG; ENOG502S028; Eukaryota.
DR GeneTree; ENSGT00950000182696; -.
DR HOGENOM; CLU_138632_0_1_1; -.
DR InParanoid; P47801; -.
DR OMA; KSVQAFM; -.
DR OrthoDB; 1218356at2759; -.
DR PhylomeDB; P47801; -.
DR TreeFam; TF330414; -.
DR BioGRID-ORCS; 13730; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Emp1; mouse.
DR PRO; PR:P47801; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P47801; protein.
DR Bgee; ENSMUSG00000030208; Expressed in substantia propria of cornea and 206 other tissues.
DR ExpressionAtlas; P47801; baseline and differential.
DR Genevisible; P47801; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0032060; P:bleb assembly; ISO:MGI.
DR GO; GO:0008219; P:cell death; ISO:MGI.
DR InterPro; IPR003932; EMP_1.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR004032; PMP22_EMP_MP20.
DR PANTHER; PTHR10671:SF6; PTHR10671:SF6; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01453; EPMEMFAMILY.
DR PRINTS; PR01454; EPMEMPROT1.
DR PROSITE; PS01221; PMP22_1; 1.
DR PROSITE; PS01222; PMP22_2; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..160
FT /note="Epithelial membrane protein 1"
FT /id="PRO_0000164654"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19656770"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 160 AA; 17813 MW; 1B91687E547A2905 CRC64;
MLVLLAGLFV VHIATAIMLF VSTIANVWMV ADYANASVGL WKNCTGGNCD GSLSYGNEDA
IKAVQAFMIL SIIFSIISLV VFVFQLFTME KGNRFFLSGS TMLVCWLCIL VGVSIYTHHY
AHSEGNFNSS SHQGYCFILT WICFCFSFII GILYMVLRKK
