ID   EMP1_RABIT              Reviewed;         160 AA.
AC   P54850;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Epithelial membrane protein 1;
DE            Short=EMP-1;
DE   AltName: Full=Squamous cell-specific protein CL-20;
DE   AltName: Full=Tumor-associated membrane protein;
GN   Name=EMP1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white;
RX   PubMed=7499420; DOI=10.1074/jbc.270.48.28910;
RA   Marvin K.W., Fujimoto W., Jetten A.M.;
RT   "Identification and characterization of a novel squamous cell-associated
RT   gene related to PMP22.";
RL   J. Biol. Chem. 270:28910-28916(1995).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Most abundant in squamous epithelia.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
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DR   EMBL; U34200; AAC48488.1; -; mRNA.
DR   RefSeq; NP_001075826.1; NM_001082357.1.
DR   AlphaFoldDB; P54850; -.
DR   SMR; P54850; -.
DR   STRING; 9986.ENSOCUP00000025750; -.
DR   GeneID; 100009209; -.
DR   KEGG; ocu:100009209; -.
DR   CTD; 2012; -.
DR   eggNOG; ENOG502S028; Eukaryota.
DR   InParanoid; P54850; -.
DR   OrthoDB; 1218356at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR003932; EMP_1.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR004032; PMP22_EMP_MP20.
DR   PANTHER; PTHR10671:SF6; PTHR10671:SF6; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01453; EPMEMFAMILY.
DR   PRINTS; PR01454; EPMEMPROT1.
DR   PROSITE; PS01221; PMP22_1; 1.
DR   PROSITE; PS01222; PMP22_2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..160
FT                   /note="Epithelial membrane protein 1"
FT                   /id="PRO_0000164656"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        35
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        43
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   160 AA;  17758 MW;  15D01C904092D188 CRC64;
     MLVLLAAIFV VHIATCVMLF VSTIANVWVV SDSINASVGL WRNCTSGDCS GGLSYGHEDA
     LKAVQAFMIL SIIFSVISLI IFVFQLFTME KGNRFFLSGA TMLVCWLCVL IGASIYTHRY
     ANGDSNTFDR SHHGYSFILA WICFCFSFVV GVLYLVLRKK