EMP1_RAT
ID EMP1_RAT Reviewed; 160 AA.
AC P54848;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Epithelial membrane protein 1;
DE Short=EMP-1;
DE AltName: Full=Tumor-associated membrane protein;
GN Name=Emp1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Intestine;
RX PubMed=7499407; DOI=10.1074/jbc.270.48.28824;
RA Taylor V., Welcher A.A., Suter U.;
RT "Epithelial membrane protein-1, peripheral myelin protein 22, and lens
RT membrane protein 20 define a novel gene family.";
RL J. Biol. Chem. 270:28824-28833(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Most prominently found in the gastrointestinal
CC tract, skin, lung, and brain but not in liver.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
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DR EMBL; Z54212; CAA90939.1; -; mRNA.
DR EMBL; BC087031; AAH87031.1; -; mRNA.
DR RefSeq; NP_036975.1; NM_012843.2.
DR RefSeq; XP_008761591.1; XM_008763369.2.
DR AlphaFoldDB; P54848; -.
DR SMR; P54848; -.
DR STRING; 10116.ENSRNOP00000011580; -.
DR GlyGen; P54848; 1 site.
DR PaxDb; P54848; -.
DR Ensembl; ENSRNOT00000011580; ENSRNOP00000011580; ENSRNOG00000008676.
DR GeneID; 25314; -.
DR KEGG; rno:25314; -.
DR UCSC; RGD:2552; rat.
DR CTD; 2012; -.
DR RGD; 2552; Emp1.
DR eggNOG; ENOG502S028; Eukaryota.
DR GeneTree; ENSGT00950000182696; -.
DR HOGENOM; CLU_138632_0_1_1; -.
DR InParanoid; P54848; -.
DR OMA; KSVQAFM; -.
DR OrthoDB; 1218356at2759; -.
DR PhylomeDB; P54848; -.
DR TreeFam; TF330414; -.
DR PRO; PR:P54848; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000008676; Expressed in esophagus and 18 other tissues.
DR Genevisible; P54848; RN.
DR GO; GO:0016021; C:integral component of membrane; TAS:RGD.
DR GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR GO; GO:0032060; P:bleb assembly; ISO:RGD.
DR GO; GO:0008219; P:cell death; ISO:RGD.
DR InterPro; IPR003932; EMP_1.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR004032; PMP22_EMP_MP20.
DR PANTHER; PTHR10671:SF6; PTHR10671:SF6; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01453; EPMEMFAMILY.
DR PRINTS; PR01454; EPMEMPROT1.
DR PROSITE; PS01221; PMP22_1; 1.
DR PROSITE; PS01222; PMP22_2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..160
FT /note="Epithelial membrane protein 1"
FT /id="PRO_0000164657"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 160 AA; 17826 MW; 3B3144A22B93860F CRC64;
MLVLLAGLFV VHIATAIMLF VSTIANVWMV ADGIDSSIGL WKNCTSGSCD GSLSYGNDDA
IKAVQAFMIL SIIFSIISLV VFVFQLFTME KGNRFFLSGS TMLVCWLCIL IGVSIYTHHY
AHSEGNFFPS SHQGYCFILT WICFCFSFII GILYMVLRKK
