ID   EMP3_BOVIN              Reviewed;         163 AA.
AC   Q58DR6; A0JNM3;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Epithelial membrane protein 3;
DE            Short=EMP-3;
GN   Name=EMP3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal medulla;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably involved in cell proliferation and cell-cell
CC       interactions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
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DR   EMBL; BT021531; AAX46378.1; -; mRNA.
DR   EMBL; BC126787; AAI26788.1; -; mRNA.
DR   RefSeq; NP_001019733.1; NM_001024562.1.
DR   RefSeq; XP_015313659.1; XM_015458173.1.
DR   AlphaFoldDB; Q58DR6; -.
DR   SMR; Q58DR6; -.
DR   STRING; 9913.ENSBTAP00000023976; -.
DR   PaxDb; Q58DR6; -.
DR   Ensembl; ENSBTAT00000023976; ENSBTAP00000023976; ENSBTAG00000018013.
DR   GeneID; 535273; -.
DR   KEGG; bta:535273; -.
DR   CTD; 2014; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018013; -.
DR   VGNC; VGNC:28483; EMP3.
DR   eggNOG; ENOG502RZP6; Eukaryota.
DR   GeneTree; ENSGT00950000182696; -.
DR   HOGENOM; CLU_138632_1_0_1; -.
DR   InParanoid; Q58DR6; -.
DR   OMA; CRFDNFT; -.
DR   OrthoDB; 1420219at2759; -.
DR   TreeFam; TF330414; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000018013; Expressed in blood and 103 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0032060; P:bleb assembly; IEA:Ensembl.
DR   GO; GO:0008219; P:cell death; IEA:Ensembl.
DR   InterPro; IPR003934; EMP_3.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR004032; PMP22_EMP_MP20.
DR   PANTHER; PTHR10671:SF8; PTHR10671:SF8; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01453; EPMEMFAMILY.
DR   PRINTS; PR01456; EPMEMPROT3.
DR   PROSITE; PS01221; PMP22_1; 1.
DR   PROSITE; PS01222; PMP22_2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..163
FT                   /note="Epithelial membrane protein 3"
FT                   /id="PRO_0000244414"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        49
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        56
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   163 AA;  18300 MW;  6E180D986AFB2F5B CRC64;
     MSLLLLVVSA LHILILILLF VATLDKSWWT LPGKESLNLW YDCTWNSDNK TWACSNVSEN
     GWLKAVQVLM VLSLILCCLS FILFMFQLYT MRRGGLFYAT GFCQLCTSVA VFTGALIYAI
     HAEEILADRP SGGSFGYCFA LAWVAFPLAL ASGIIYIHLR KRE