EMP3_HUMAN
ID EMP3_HUMAN Reviewed; 163 AA.
AC P54852; Q6FH01;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Epithelial membrane protein 3;
DE Short=EMP-3;
DE AltName: Full=Hematopoietic neural membrane protein 1;
DE Short=HNMP-1;
DE AltName: Full=Protein YMP;
GN Name=EMP3; Synonyms=YMP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8996089; DOI=10.1016/s0378-1119(96)00475-1;
RA Ben-Porath I., Benvenisty N.;
RT "Characterization of a tumor-associated gene, a member of a novel family of
RT genes encoding membrane glycoproteins.";
RL Gene 183:69-75(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spleen;
RX PubMed=8917086; DOI=10.1016/0378-1119(96)00134-5;
RA Taylor V., Suter U.;
RT "Epithelial membrane protein-2 and epithelial membrane protein-3: two novel
RT members of the peripheral myelin protein 22 gene family.";
RL Gene 175:115-120(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9204931; DOI=10.1523/jneurosci.17-14-05493.1997;
RA Bolin L.M., McNeil T., Lucian L.A., Devaux B., Franz-Bacon K., Gorman D.M.,
RA Zurawski S., Murray R., McClanahan T.K.;
RT "HNMP-1: a novel hematopoietic and neural membrane protein differentially
RT regulated in neural development and injury.";
RL J. Neurosci. 17:5493-5502(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probably involved in cell proliferation and cell-cell
CC interactions.
CC -!- INTERACTION:
CC P54852; Q13520: AQP6; NbExp=3; IntAct=EBI-3907816, EBI-13059134;
CC P54852; Q9NW68: BSDC1; NbExp=3; IntAct=EBI-3907816, EBI-721848;
CC P54852; P11912: CD79A; NbExp=3; IntAct=EBI-3907816, EBI-7797864;
CC P54852; P57739: CLDN2; NbExp=3; IntAct=EBI-3907816, EBI-751440;
CC P54852; O95471: CLDN7; NbExp=3; IntAct=EBI-3907816, EBI-740744;
CC P54852; Q96DZ9: CMTM5; NbExp=3; IntAct=EBI-3907816, EBI-2548702;
CC P54852; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-3907816, EBI-6942903;
CC P54852; Q92838: EDA; NbExp=7; IntAct=EBI-3907816, EBI-529425;
CC P54852; A1L3X0: ELOVL7; NbExp=3; IntAct=EBI-3907816, EBI-10285373;
CC P54852; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-3907816, EBI-781551;
CC P54852; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-3907816, EBI-18938272;
CC P54852; O75955: FLOT1; NbExp=3; IntAct=EBI-3907816, EBI-603643;
CC P54852; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-3907816, EBI-12142257;
CC P54852; P36382: GJA5; NbExp=3; IntAct=EBI-3907816, EBI-750433;
CC P54852; P08034: GJB1; NbExp=3; IntAct=EBI-3907816, EBI-17565645;
CC P54852; Q99795: GPA33; NbExp=3; IntAct=EBI-3907816, EBI-4289554;
CC P54852; Q9BZJ8: GPR61; NbExp=3; IntAct=EBI-3907816, EBI-12808020;
CC P54852; Q9BUP3: HTATIP2; NbExp=3; IntAct=EBI-3907816, EBI-13625358;
CC P54852; P38484: IFNGR2; NbExp=3; IntAct=EBI-3907816, EBI-3905457;
CC P54852; P26951: IL3RA; NbExp=3; IntAct=EBI-3907816, EBI-1757512;
CC P54852; Q8N743: KIR3DL3; NbExp=3; IntAct=EBI-3907816, EBI-17272405;
CC P54852; P26715: KLRC1; NbExp=4; IntAct=EBI-3907816, EBI-9018187;
CC P54852; Q5T700: LDLRAD1; NbExp=3; IntAct=EBI-3907816, EBI-10173166;
CC P54852; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-3907816, EBI-17490413;
CC P54852; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-3907816, EBI-2820517;
CC P54852; Q9HCJ2: LRRC4C; NbExp=3; IntAct=EBI-3907816, EBI-3925442;
CC P54852; Q9Y5Y7: LYVE1; NbExp=3; IntAct=EBI-3907816, EBI-10329546;
CC P54852; Q95460-2: MR1; NbExp=3; IntAct=EBI-3907816, EBI-12201447;
CC P54852; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-3907816, EBI-12806656;
CC P54852; P15941-11: MUC1; NbExp=3; IntAct=EBI-3907816, EBI-17263240;
CC P54852; P35372-10: OPRM1; NbExp=3; IntAct=EBI-3907816, EBI-12807478;
CC P54852; Q96CS7: PLEKHB2; NbExp=3; IntAct=EBI-3907816, EBI-373552;
CC P54852; Q04941: PLP2; NbExp=3; IntAct=EBI-3907816, EBI-608347;
CC P54852; P10114: RAP2A; NbExp=3; IntAct=EBI-3907816, EBI-602366;
CC P54852; Q96TC7: RMDN3; NbExp=3; IntAct=EBI-3907816, EBI-1056589;
CC P54852; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-3907816, EBI-3920694;
CC P54852; Q8WVN6: SECTM1; NbExp=3; IntAct=EBI-3907816, EBI-2855289;
CC P54852; Q8N7X8: SIGLECL1; NbExp=3; IntAct=EBI-3907816, EBI-18052611;
CC P54852; Q9P0V8: SLAMF8; NbExp=3; IntAct=EBI-3907816, EBI-18164173;
CC P54852; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-3907816, EBI-8644112;
CC P54852; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-3907816, EBI-17295964;
CC P54852; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-3907816, EBI-741850;
CC P54852; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-3907816, EBI-17498703;
CC P54852; Q96CE8: TM4SF18; NbExp=3; IntAct=EBI-3907816, EBI-13351685;
CC P54852; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-3907816, EBI-726044;
CC P54852; Q9Y320: TMX2; NbExp=3; IntAct=EBI-3907816, EBI-6447886;
CC P54852; O95859: TSPAN12; NbExp=3; IntAct=EBI-3907816, EBI-2466403;
CC P54852; Q15836: VAMP3; NbExp=3; IntAct=EBI-3907816, EBI-722343;
CC P54852; Q86XK7: VSIG1; NbExp=3; IntAct=EBI-3907816, EBI-18323486;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
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DR EMBL; U52101; AAC50920.1; -; mRNA.
DR EMBL; X94771; CAA64394.1; -; mRNA.
DR EMBL; U87947; AAC51730.1; -; mRNA.
DR EMBL; BT007124; AAP35788.1; -; mRNA.
DR EMBL; CR541955; CAG46753.1; -; mRNA.
DR EMBL; CH471177; EAW52333.1; -; Genomic_DNA.
DR EMBL; BC009718; AAH09718.1; -; mRNA.
DR CCDS; CCDS12715.1; -.
DR PIR; JC5045; JC5045.
DR RefSeq; NP_001300834.1; NM_001313905.1.
DR RefSeq; NP_001416.1; NM_001425.2.
DR RefSeq; XP_011524907.1; XM_011526605.2.
DR AlphaFoldDB; P54852; -.
DR SMR; P54852; -.
DR BioGRID; 108329; 73.
DR IntAct; P54852; 53.
DR MINT; P54852; -.
DR STRING; 9606.ENSP00000270221; -.
DR GlyGen; P54852; 3 sites.
DR iPTMnet; P54852; -.
DR PhosphoSitePlus; P54852; -.
DR SwissPalm; P54852; -.
DR BioMuta; EMP3; -.
DR DMDM; 1706644; -.
DR EPD; P54852; -.
DR jPOST; P54852; -.
DR MassIVE; P54852; -.
DR MaxQB; P54852; -.
DR PaxDb; P54852; -.
DR PeptideAtlas; P54852; -.
DR PRIDE; P54852; -.
DR ProteomicsDB; 56741; -.
DR TopDownProteomics; P54852; -.
DR Antibodypedia; 31695; 233 antibodies from 26 providers.
DR DNASU; 2014; -.
DR Ensembl; ENST00000270221.11; ENSP00000270221.5; ENSG00000142227.11.
DR Ensembl; ENST00000597279.5; ENSP00000469194.1; ENSG00000142227.11.
DR GeneID; 2014; -.
DR KEGG; hsa:2014; -.
DR MANE-Select; ENST00000270221.11; ENSP00000270221.5; NM_001425.3; NP_001416.1.
DR UCSC; uc002piv.3; human.
DR CTD; 2014; -.
DR DisGeNET; 2014; -.
DR GeneCards; EMP3; -.
DR HGNC; HGNC:3335; EMP3.
DR HPA; ENSG00000142227; Low tissue specificity.
DR MIM; 602335; gene.
DR neXtProt; NX_P54852; -.
DR OpenTargets; ENSG00000142227; -.
DR PharmGKB; PA27772; -.
DR VEuPathDB; HostDB:ENSG00000142227; -.
DR eggNOG; ENOG502RZP6; Eukaryota.
DR GeneTree; ENSGT00950000182696; -.
DR HOGENOM; CLU_138632_1_0_1; -.
DR InParanoid; P54852; -.
DR OMA; CRFDNFT; -.
DR OrthoDB; 1420219at2759; -.
DR PhylomeDB; P54852; -.
DR TreeFam; TF330414; -.
DR PathwayCommons; P54852; -.
DR SignaLink; P54852; -.
DR BioGRID-ORCS; 2014; 11 hits in 1088 CRISPR screens.
DR ChiTaRS; EMP3; human.
DR GeneWiki; EMP3; -.
DR GenomeRNAi; 2014; -.
DR Pharos; P54852; Tbio.
DR PRO; PR:P54852; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P54852; protein.
DR Bgee; ENSG00000142227; Expressed in granulocyte and 180 other tissues.
DR ExpressionAtlas; P54852; baseline and differential.
DR Genevisible; P54852; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0032060; P:bleb assembly; IDA:UniProtKB.
DR GO; GO:0008219; P:cell death; IDA:UniProtKB.
DR InterPro; IPR003934; EMP_3.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR004032; PMP22_EMP_MP20.
DR PANTHER; PTHR10671:SF8; PTHR10671:SF8; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01453; EPMEMFAMILY.
DR PRINTS; PR01456; EPMEMPROT3.
DR PROSITE; PS01221; PMP22_1; 1.
DR PROSITE; PS01222; PMP22_2; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..163
FT /note="Epithelial membrane protein 3"
FT /id="PRO_0000164660"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 125
FT /note="I -> V (in dbSNP:rs4893)"
FT /id="VAR_050609"
FT CONFLICT 100..101
FT /note="TG -> HR (in Ref. 2; CAA64394)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 163 AA; 18429 MW; 2B5DF55938825940 CRC64;
MSLLLLVVSA LHILILILLF VATLDKSWWT LPGKESLNLW YDCTWNNDTK TWACSNVSEN
GWLKAVQVLM VLSLILCCLS FILFMFQLYT MRRGGLFYAT GLCQLCTSVA VFTGALIYAI
HAEEILEKHP RGGSFGYCFA LAWVAFPLAL VSGIIYIHLR KRE
