ID   EMP3_RAT                Reviewed;         163 AA.
AC   Q9QYW5;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Epithelial membrane protein 3;
DE            Short=EMP-3;
GN   Name=Emp3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=10570147; DOI=10.1073/pnas.96.24.13766;
RA   Zucchi I., Montagna C., Susani L., Montesano R., Affer M., Zanotti S.,
RA   Redolfi E., Vezzoni P., Dulbecco R.;
RT   "Genetic dissection of dome formation in a mammary cell line:
RT   identification of two genes with opposing action.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:13766-13770(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probably involved in cell proliferation and cell-cell
CC       interactions.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
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DR   EMBL; Y10889; CAB61834.1; -; mRNA.
DR   EMBL; BC088131; AAH88131.1; -; mRNA.
DR   RefSeq; NP_110474.1; NM_030847.1.
DR   RefSeq; XP_006229220.1; XM_006229158.3.
DR   RefSeq; XP_008757640.1; XM_008759418.1.
DR   AlphaFoldDB; Q9QYW5; -.
DR   SMR; Q9QYW5; -.
DR   STRING; 10116.ENSRNOP00000028656; -.
DR   GlyGen; Q9QYW5; 2 sites.
DR   PaxDb; Q9QYW5; -.
DR   Ensembl; ENSRNOT00000028656; ENSRNOP00000028656; ENSRNOG00000021104.
DR   GeneID; 81505; -.
DR   KEGG; rno:81505; -.
DR   UCSC; RGD:621094; rat.
DR   CTD; 2014; -.
DR   RGD; 621094; Emp3.
DR   eggNOG; ENOG502RZP6; Eukaryota.
DR   GeneTree; ENSGT00950000182696; -.
DR   HOGENOM; CLU_138632_1_0_1; -.
DR   InParanoid; Q9QYW5; -.
DR   OMA; CRFDNFT; -.
DR   OrthoDB; 1420219at2759; -.
DR   PhylomeDB; Q9QYW5; -.
DR   TreeFam; TF330414; -.
DR   PRO; PR:Q9QYW5; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000021104; Expressed in ovary and 19 other tissues.
DR   Genevisible; Q9QYW5; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0032060; P:bleb assembly; ISO:RGD.
DR   GO; GO:0008219; P:cell death; ISO:RGD.
DR   InterPro; IPR003934; EMP_3.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR004032; PMP22_EMP_MP20.
DR   PANTHER; PTHR10671:SF8; PTHR10671:SF8; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01453; EPMEMFAMILY.
DR   PRINTS; PR01456; EPMEMPROT3.
DR   PROSITE; PS01221; PMP22_1; 1.
DR   PROSITE; PS01222; PMP22_2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..163
FT                   /note="Epithelial membrane protein 3"
FT                   /id="PRO_0000164662"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        56
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   163 AA;  18198 MW;  8B395380D0C92558 CRC64;
     MSLLLLVVSA LHILILVLLF VATLDKSWWT LPEKESLNLW YDCTWNTTAK TWACSNVSEN
     GWLKAVQALM VLSLILCCLS FILFMIQLYT MRRGGLFYAT GLCQLCTSAA VFSGALIYAI
     HAKEILAKHP SGGSFGYCFA LAWVAFPLAL VSGIIYIHLR KRE