ID   EMR1_YEAST              Reviewed;          52 AA.
AC   Q3E828; D6VW58;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=ERMES regulator 1 {ECO:0000305};
GN   Name=MCO6 {ECO:0000312|SGD:S000028522};
GN   OrderedLocusNames=YJL127C-B {ECO:0000312|SGD:S000028522};
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA   Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA   Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA   Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA   Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA   Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA   Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA   Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA   To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA   von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   GENOME REANNOTATION.
RX   PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
RA   Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
RA   Gates K., Gaffney T.D., Philippsen P.;
RT   "Reinvestigation of the Saccharomyces cerevisiae genome annotation by
RT   comparison to the genome of a related fungus: Ashbya gossypii.";
RL   Genome Biol. 4:R45.1-R45.13(2003).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=26928762; DOI=10.1038/nmeth.3795;
RA   Yofe I., Weill U., Meurer M., Chuartzman S., Zalckvar E., Goldman O.,
RA   Ben-Dor S., Schuetze C., Wiedemann N., Knop M., Khmelinskii A.,
RA   Schuldiner M.;
RT   "One library to make them all: streamlining the creation of yeast libraries
RT   via a SWAp-Tag strategy.";
RL   Nat. Methods 13:371-378(2016).
CC   -!- FUNCTION: Mediates the formation of endoplasmic reticulum (ER)-
CC       mitochondria encounter structure (ERMES) foci, thereby contributing to
CC       the formation of ER-mitochondrial contact sites.
CC       {ECO:0000250|UniProtKB:Q4ZGE1}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000269|PubMed:26928762}; Single-pass type III membrane protein
CC       {ECO:0000250|UniProtKB:Q4ZGE1}.
CC   -!- SIMILARITY: Belongs to the EMR1 family. {ECO:0000305}.
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DR   EMBL; Z49402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK006943; DAA08674.1; -; Genomic_DNA.
DR   RefSeq; NP_878103.1; NM_001184532.1.
DR   AlphaFoldDB; Q3E828; -.
DR   BioGRID; 37008; 33.
DR   STRING; 4932.YJL127C-B; -.
DR   PaxDb; Q3E828; -.
DR   PRIDE; Q3E828; -.
DR   EnsemblFungi; YJL127C-B_mRNA; YJL127C-B; YJL127C-B.
DR   GeneID; 1466466; -.
DR   KEGG; sce:YJL127C-B; -.
DR   SGD; S000028522; YJL127C-B.
DR   VEuPathDB; FungiDB:YJL127C-B; -.
DR   eggNOG; ENOG502SBQD; Eukaryota.
DR   HOGENOM; CLU_3088968_0_0_1; -.
DR   InParanoid; Q3E828; -.
DR   OMA; FFQFLGY; -.
DR   BioCyc; YEAST:G3O-31804-MON; -.
DR   PRO; PR:Q3E828; -.
DR   Proteomes; UP000002311; Chromosome X.
DR   RNAct; Q3E828; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0007008; P:outer mitochondrial membrane organization; IEA:InterPro.
DR   InterPro; IPR035195; Emr1.
DR   Pfam; PF17237; DUF5310; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..52
FT                   /note="ERMES regulator 1"
FT                   /id="PRO_0000245410"
FT   TOPO_DOM        1..27
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:Q4ZGE1"
FT   TRANSMEM        28..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q4ZGE1"
SQ   SEQUENCE   52 AA;  6017 MW;  A1CBFF3B98C8CFAA CRC64;
     MIFFFNQIRS IFTALHTPTQ QIQLSRRAFF QFLGYLGSCV VISLAAQSKY VQ