ID   EMRA_HAEIN              Reviewed;         390 AA.
AC   P44928;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Multidrug export protein EmrA;
GN   Name=emrA; OrderedLocusNames=HI_0898;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Confers resistance to antibiotics. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}; Periplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22558.1; -; Genomic_DNA.
DR   PIR; B64101; B64101.
DR   RefSeq; NP_439059.1; NC_000907.1.
DR   RefSeq; WP_005693250.1; NC_000907.1.
DR   AlphaFoldDB; P44928; -.
DR   SMR; P44928; -.
DR   STRING; 71421.HI_0898; -.
DR   EnsemblBacteria; AAC22558; AAC22558; HI_0898.
DR   KEGG; hin:HI_0898; -.
DR   PATRIC; fig|71421.8.peg.940; -.
DR   eggNOG; COG1566; Bacteria.
DR   HOGENOM; CLU_018816_15_0_6; -.
DR   OMA; QYSDSHP; -.
DR   PhylomeDB; P44928; -.
DR   BioCyc; HINF71421:G1GJ1-938-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   InterPro; IPR043602; CusB_dom_1.
DR   InterPro; IPR005694; Efflux_pump_mem.
DR   InterPro; IPR032317; HlyD_D23.
DR   Pfam; PF00529; CusB_dom_1; 1.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   TIGRFAMs; TIGR00998; 8a0101; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell inner membrane; Cell membrane; Coiled coil;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..390
FT                   /note="Multidrug export protein EmrA"
FT                   /id="PRO_0000201870"
FT   TOPO_DOM        1..25
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..390
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   COILED          160..190
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   390 AA;  43062 MW;  42CF0AFA588BAFD8 CRC64;
     MTQIATENPS TKSVSNKTDR KKGLSIFILL LLIIGIACAL YWFFFLKDFE ETEDAYVGGN
     QVMVSSQVAG NVAKINADNM DKVHAGDILV ELDDTNAKLS FEQAKSNLAN AVRQVEQLGF
     TVQQLQSAVH ANEISLAQAQ GNLARRVQLE KMGAIDKESF QHAKEAVELA KANLNASKNQ
     LAANQALLRN VPLREQPQIQ NAINSLKQAW LNLQRTKIRS PIDGYVARRN VQVGQAVSVG
     GALMAVVSNE QMWLEANFKE TQLTNMRIGQ PVKIHFDLYG KNKEFDGVIN GIEMGTGNAF
     SLLPSQNATG NWIKVVQRVP VRIKLDPQQF TETPLRIGLS ATAKVRISDS SGAMLREKTE
     PKTLFSTDTL KYDESAVENL IESIIQQNSH