ID   EMRB_MYCTU              Reviewed;         540 AA.
AC   P9WG89; L0T4Q5; P71836; Q8VKE2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Multidrug resistance protein B homolog;
GN   Name=emrB; OrderedLocusNames=Rv0783c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP43530.1; -; Genomic_DNA.
DR   PIR; B70709; B70709.
DR   RefSeq; NP_215297.1; NC_000962.3.
DR   RefSeq; WP_003403977.1; NZ_NVQJ01000035.1.
DR   AlphaFoldDB; P9WG89; -.
DR   SMR; P9WG89; -.
DR   STRING; 83332.Rv0783c; -.
DR   PaxDb; P9WG89; -.
DR   DNASU; 885836; -.
DR   GeneID; 885836; -.
DR   KEGG; mtu:Rv0783c; -.
DR   TubercuList; Rv0783c; -.
DR   eggNOG; COG0477; Bacteria.
DR   OMA; FKIHTFS; -.
DR   PhylomeDB; P9WG89; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..540
FT                   /note="Multidrug resistance protein B homolog"
FT                   /id="PRO_0000390687"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        505..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   540 AA;  56587 MW;  C24BF33DEE8D01E7 CRC64;
     MLGNAMVEAC PAEGDAPVPI TPAGRPRSGQ RSYPDRLDVG LLRTAGVCVL ASVMAHVDVT
     VVSVAQRTFV ADFGSTQAVV AWTMTGYMLA LATVIPTAGW AADRFGTRRL FMGSVLAFTL
     GSLLCAVAPN ILLLIIFRVV QGFGGGMLTP VSFAILAREA GPKRLGRVMA VVGIPMLLGP
     VGGPILGGWL IGAYGWRWIF LVNLPVGLSA LVLAAIVFPR DRPAASENFD YMGLLLLSPG
     LATFLFGVSS SPARGTMADR HVLIPAITGL ALIAAFVAHS WYRTEHPLID MRLFQNRAVA
     QANMTMTVLS LGLFGSFLLL PSYLQQVLHQ SPMQSGVHII PQGLGAMLAM PIAGAMMDRR
     GPAKIVLVGI MLIAAGLGTF AFGVARQADY LPILPTGLAI MGMGMGCSMM PLSGAAVQTL
     APHQIARGST LISVNQQVGG SIGTALMSVL LTYQFNHSEI IATAKKVALT PESGAGRGAA
     VDPSSLPRQT NFAAQLLHDL SHAYAVVFVI ATALVVSTLI PAAFLPKQQA SHRRAPLLSA