ID   EMRE_AEDAE              Reviewed;          91 AA.
AC   Q17ED3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Essential MCU regulator, mitochondrial {ECO:0000250|UniProtKB:Q9H4I9};
DE   Flags: Precursor;
GN   ORFNames=AAEL003858;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:EAT44843.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Essential regulatory subunit of the mitochondrial calcium
CC       uniporter (mcu) channel, a protein that mediates calcium uptake into
CC       mitochondria. {ECO:0000250|UniProtKB:Q9H4I9}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9H4I9}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9H4I9}.
CC   -!- SIMILARITY: Belongs to the SMDT1/EMRE family. {ECO:0000305}.
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DR   EMBL; CH477283; EAT44843.1; -; Genomic_DNA.
DR   RefSeq; XP_001657299.1; XM_001657249.1.
DR   AlphaFoldDB; Q17ED3; -.
DR   SMR; Q17ED3; -.
DR   STRING; 7159.AAEL003858-PA; -.
DR   VEuPathDB; VectorBase:AAEL003858; -.
DR   eggNOG; KOG4542; Eukaryota.
DR   HOGENOM; CLU_172921_0_1_1; -.
DR   InParanoid; Q17ED3; -.
DR   OMA; RKYTYRS; -.
DR   OrthoDB; 1586309at2759; -.
DR   PhylomeDB; Q17ED3; -.
DR   Proteomes; UP000008820; Chromosome 3.
DR   GO; GO:1990246; C:uniplex complex; IEA:InterPro.
DR   GO; GO:0036444; P:calcium import into the mitochondrion; IEA:InterPro.
DR   GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:InterPro.
DR   InterPro; IPR018782; MCU_reg.
DR   PANTHER; PTHR33904; PTHR33904; 1.
DR   Pfam; PF10161; DDDD; 1.
PE   3: Inferred from homology;
KW   Calcium; Calcium transport; Ion transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..91
FT                   /note="Essential MCU regulator, mitochondrial"
FT                   /id="PRO_0000307347"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   91 AA;  9963 MW;  1580F709C7C9EA2E CRC64;
     MVLSNVVRVV NRLNSAGTRS GLMGIRQLRR KYTYRSGALK PMPNVIPFGL LGVVLTVIPG
     LLIGATISKN MANFLEENDL FVPSDDDDDD D