ID   EMRE_ANOGA              Reviewed;          98 AA.
AC   Q7QHP6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Essential MCU regulator, mitochondrial {ECO:0000250|UniProtKB:Q9H4I9};
DE   Flags: Precursor;
GN   ORFNames=AGAP011291;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1] {ECO:0000312|EMBL:EAA05035.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000312|EMBL:EAA05035.2};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Essential regulatory subunit of the mitochondrial calcium
CC       uniporter (mcu) channel, a protein that mediates calcium uptake into
CC       mitochondria. {ECO:0000250|UniProtKB:Q9H4I9}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9H4I9}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9H4I9}.
CC   -!- SIMILARITY: Belongs to the SMDT1/EMRE family. {ECO:0000305}.
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DR   EMBL; AAAB01008816; EAA05035.2; -; Genomic_DNA.
DR   RefSeq; XP_309357.2; XM_309357.4.
DR   AlphaFoldDB; Q7QHP6; -.
DR   SMR; Q7QHP6; -.
DR   STRING; 7165.AGAP011291-PA; -.
DR   PaxDb; Q7QHP6; -.
DR   GeneID; 1270642; -.
DR   KEGG; aga:AgaP_AGAP011291; -.
DR   CTD; 1270642; -.
DR   VEuPathDB; VectorBase:AGAP011291; -.
DR   eggNOG; KOG4542; Eukaryota.
DR   HOGENOM; CLU_172921_0_1_1; -.
DR   InParanoid; Q7QHP6; -.
DR   OMA; RKYTYRS; -.
DR   OrthoDB; 1586309at2759; -.
DR   PhylomeDB; Q7QHP6; -.
DR   Proteomes; UP000007062; Chromosome 3L.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:1990246; C:uniplex complex; IBA:GO_Central.
DR   GO; GO:0036444; P:calcium import into the mitochondrion; IBA:GO_Central.
DR   GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR018782; MCU_reg.
DR   PANTHER; PTHR33904; PTHR33904; 1.
DR   Pfam; PF10161; DDDD; 1.
PE   3: Inferred from homology;
KW   Calcium; Calcium transport; Ion transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..98
FT                   /note="Essential MCU regulator, mitochondrial"
FT                   /id="PRO_0000307348"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   98 AA;  10577 MW;  F2E43CC6F3B25324 CRC64;
     MVLTRVIRAV GRSTLLETGV AGSGGGQLQL VRLPLRRKYT YRSGALKPMP EITPFGLFGI
     IATVIPGLLI GATISKNMAN FLEENDLFVP SDDDDDDD