EMRE_CAEEL
ID EMRE_CAEEL Reviewed; 90 AA.
AC Q9U3I4;
DT 07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Essential MCU regulator, mitochondrial {ECO:0000250|UniProtKB:Q9H4I9};
DE Flags: Precursor;
GN Name=emre-1 {ECO:0000312|WormBase:F20D1.10};
GN Synonyms=tag-299 {ECO:0000312|WormBase:F20D1.10};
GN ORFNames=F20D1.10 {ECO:0000312|WormBase:F20D1.10};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION.
RX PubMed=27099988; DOI=10.7554/elife.15545;
RA Tsai M.F., Phillips C.B., Ranaghan M., Tsai C.W., Wu Y., Willliams C.,
RA Miller C.;
RT "Dual functions of a small regulatory subunit in the mitochondrial calcium
RT uniporter complex.";
RL Elife 5:0-0(2016).
CC -!- FUNCTION: Essential regulatory subunit of the mitochondrial calcium
CC uniporter (mcu-1) channel, a protein that mediates calcium uptake into
CC mitochondria. {ECO:0000269|PubMed:27099988}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9H4I9}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9H4I9}.
CC -!- SIMILARITY: Belongs to the SMDT1/EMRE family. {ECO:0000305}.
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DR EMBL; BX284606; CAB54233.1; -; Genomic_DNA.
DR PIR; T21150; T21150.
DR RefSeq; NP_510487.1; NM_078086.3.
DR AlphaFoldDB; Q9U3I4; -.
DR SMR; Q9U3I4; -.
DR DIP; DIP-25311N; -.
DR STRING; 6239.F20D1.10.2; -.
DR TCDB; 8.A.45.1.3; the essential mcu regulator emre (emre) family.
DR PaxDb; Q9U3I4; -.
DR EnsemblMetazoa; F20D1.10.1; F20D1.10.1; WBGene00008980.
DR GeneID; 181594; -.
DR KEGG; cel:CELE_F20D1.10; -.
DR UCSC; F20D1.10.1; c. elegans.
DR CTD; 181594; -.
DR WormBase; F20D1.10; CE23677; WBGene00008980; emre-1.
DR eggNOG; KOG4542; Eukaryota.
DR GeneTree; ENSGT00390000017489; -.
DR HOGENOM; CLU_172921_2_1_1; -.
DR InParanoid; Q9U3I4; -.
DR OMA; YTTTYLQ; -.
DR OrthoDB; 1586309at2759; -.
DR PhylomeDB; Q9U3I4; -.
DR Reactome; R-CEL-8949215; Mitochondrial calcium ion transport.
DR Reactome; R-CEL-8949664; Processing of SMDT1.
DR PRO; PR:Q9U3I4; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00008980; Expressed in larva and 4 other tissues.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:WormBase.
DR GO; GO:1990246; C:uniplex complex; IBA:GO_Central.
DR GO; GO:0036444; P:calcium import into the mitochondrion; IBA:GO_Central.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:UniProtKB.
DR GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; IMP:UniProtKB.
DR InterPro; IPR018782; MCU_reg.
DR PANTHER; PTHR33904; PTHR33904; 1.
DR Pfam; PF10161; DDDD; 1.
PE 3: Inferred from homology;
KW Calcium; Calcium transport; Ion transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000305"
FT CHAIN ?..90
FT /note="Essential MCU regulator, mitochondrial"
FT /id="PRO_0000437211"
FT TRANSMEM 49..68
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 90 AA; 9571 MW; 90FAEAA8A5B00126 CRC64;
MTSKTVFQNA FKTFLDFAIN SLPSTQGGLN ITATAPGGVG QRPFTNKAGV LKLIFVSASS
LYIGGLIAHK GASYLEENEI FVPTDEDDDD
