EMRE_DROPS
ID EMRE_DROPS Reviewed; 96 AA.
AC Q290M9;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Essential MCU regulator, mitochondrial {ECO:0000250|UniProtKB:Q9H4I9};
DE Flags: Precursor;
GN ORFNames=GA14609;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:EAL25333.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Essential regulatory subunit of the mitochondrial calcium
CC uniporter (mcu) channel, a protein that mediates calcium uptake into
CC mitochondria. {ECO:0000250|UniProtKB:Q7JX57}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9H4I9}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9H4I9}.
CC -!- SIMILARITY: Belongs to the SMDT1/EMRE family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL25333.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CM000071; EAL25333.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001360758.1; XM_001360721.3.
DR AlphaFoldDB; Q290M9; -.
DR SMR; Q290M9; -.
DR STRING; 7237.FBpp0276671; -.
DR EnsemblMetazoa; FBtr0366474; FBpp0329628; FBgn0074636.
DR GeneID; 4804152; -.
DR KEGG; dpo:Dpse_GA14609; -.
DR eggNOG; KOG4542; Eukaryota.
DR HOGENOM; CLU_172921_0_0_1; -.
DR InParanoid; Q290M9; -.
DR OMA; AFPISHA; -.
DR PhylomeDB; Q290M9; -.
DR Proteomes; UP000001819; Chromosome 3.
DR Bgee; FBgn0074636; Expressed in female reproductive system and 2 other tissues.
DR GO; GO:1990246; C:uniplex complex; IEA:InterPro.
DR GO; GO:0036444; P:calcium import into the mitochondrion; IEA:InterPro.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; ISS:UniProtKB.
DR GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; ISS:UniProtKB.
DR InterPro; IPR018782; MCU_reg.
DR PANTHER; PTHR33904; PTHR33904; 1.
DR Pfam; PF10161; DDDD; 1.
PE 3: Inferred from homology;
KW Calcium; Calcium transport; Ion transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..34
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 35..96
FT /note="Essential MCU regulator, mitochondrial"
FT /id="PRO_0000307349"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 96 AA; 10543 MW; 5F17712580CEF1FB CRC64;
MIVSRLTFPL QAAKLVARKA AGNPSNSIIQ RRHMSGVYFR SGALRPKPDE MPFGLFAIFC
AVIPGLFIGA TISKNVANFL EENDLFVPSD DDDDED
