ID   EMRE_XENLA              Reviewed;          97 AA.
AC   Q5XG64;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Essential MCU regulator, mitochondrial {ECO:0000250|UniProtKB:Q9H4I9};
DE   AltName: Full=Single-pass membrane protein with aspartate-rich tail 1, mitochondrial {ECO:0000250|UniProtKB:Q9H4I9};
DE   Flags: Precursor;
GN   Name=smdt1 {ECO:0000250|UniProtKB:Q9H4I9};
GN   Synonyms=emre {ECO:0000250|UniProtKB:Q9H4I9};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential regulatory subunit of the mitochondrial calcium
CC       uniporter complex (uniplex), a complex that mediates calcium uptake
CC       into mitochondria. Plays a central role in regulating the uniplex
CC       complex response to intracellular calcium signaling.
CC       {ECO:0000250|UniProtKB:Q9H4I9}.
CC   -!- SUBUNIT: Component of the uniplex complex. Interacts (via the
CC       transmembrane region) with mcu (via the first transmembrane region);
CC       the interaction is direct. {ECO:0000250|UniProtKB:Q9H4I9}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9H4I9}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9H4I9}.
CC   -!- SIMILARITY: Belongs to the SMDT1/EMRE family. {ECO:0000305}.
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DR   EMBL; BC084597; AAH84597.1; -; mRNA.
DR   RefSeq; NP_001088361.1; NM_001094892.1.
DR   AlphaFoldDB; Q5XG64; -.
DR   SMR; Q5XG64; -.
DR   DNASU; 495205; -.
DR   GeneID; 495205; -.
DR   KEGG; xla:495205; -.
DR   CTD; 495205; -.
DR   Xenbase; XB-GENE-1002280; smdt1.S.
DR   OMA; RKYTYRS; -.
DR   OrthoDB; 1586309at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 495205; Expressed in testis and 19 other tissues.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:1990246; C:uniplex complex; ISS:UniProtKB.
DR   GO; GO:0036444; P:calcium import into the mitochondrion; ISS:UniProtKB.
DR   GO; GO:0051560; P:mitochondrial calcium ion homeostasis; ISS:UniProtKB.
DR   GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; ISS:UniProtKB.
DR   InterPro; IPR018782; MCU_reg.
DR   PANTHER; PTHR33904; PTHR33904; 1.
DR   Pfam; PF10161; DDDD; 1.
PE   3: Inferred from homology;
KW   Calcium; Calcium transport; Ion transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..37
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           38..97
FT                   /note="Essential MCU regulator, mitochondrial"
FT                   /id="PRO_0000296323"
FT   TOPO_DOM        38..54
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H4I9"
FT   TRANSMEM        55..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..97
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H4I9"
SQ   SEQUENCE   97 AA;  10273 MW;  FE4F54176B138143 CRC64;
     MAARMGVLSV AGFRAAARAG GLLARPKQST AVVPCRTVIA SSAGAILPKP EKVSFGLLRV
     FTVVIPFLYI GTLISKNFAA VLEEHDIFVP EDDDDDD