ID   EMRE_XENTR              Reviewed;          99 AA.
AC   Q28ED6; A8WGX2; G1K3M5; Q5RJJ4;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Essential MCU regulator, mitochondrial {ECO:0000250|UniProtKB:Q9H4I9};
DE   AltName: Full=Single-pass membrane protein with aspartate-rich tail 1, mitochondrial {ECO:0000250|UniProtKB:Q9H4I9};
DE   Flags: Precursor;
GN   Name=smdt1 {ECO:0000250|UniProtKB:Q9H4I9};
GN   Synonyms=emre {ECO:0000250|UniProtKB:Q9H4I9};
GN   ORFNames=TNeu133h13.1 {ECO:0000303|Ref.2};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=F6, and N6; TISSUE=Skeletal muscle;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential regulatory subunit of the mitochondrial calcium
CC       uniporter complex (uniplex), a complex that mediates calcium uptake
CC       into mitochondria. Plays a central role in regulating the uniplex
CC       complex response to intracellular calcium signaling.
CC       {ECO:0000250|UniProtKB:Q9H4I9}.
CC   -!- SUBUNIT: Component of the uniplex complex. Interacts (via the
CC       transmembrane region) with mcu (via the first transmembrane region);
CC       the interaction is direct. {ECO:0000250|UniProtKB:Q9H4I9}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9H4I9}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9H4I9}.
CC   -!- SIMILARITY: Belongs to the SMDT1/EMRE family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAMC01036765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR848311; CAJ83012.1; -; mRNA.
DR   EMBL; BC086613; AAH86613.1; -; mRNA.
DR   EMBL; BC154887; AAI54888.1; -; mRNA.
DR   RefSeq; NP_001107674.1; NM_001114202.1.
DR   AlphaFoldDB; Q28ED6; -.
DR   SMR; Q28ED6; -.
DR   STRING; 8364.ENSXETP00000029647; -.
DR   PaxDb; Q28ED6; -.
DR   DNASU; 496604; -.
DR   GeneID; 496604; -.
DR   KEGG; xtr:496604; -.
DR   CTD; 91689; -.
DR   Xenbase; XB-GENE-1002274; smdt1.
DR   eggNOG; KOG4542; Eukaryota.
DR   HOGENOM; CLU_172921_1_0_1; -.
DR   InParanoid; Q28ED6; -.
DR   OrthoDB; 1586309at2759; -.
DR   PhylomeDB; Q28ED6; -.
DR   TreeFam; TF314649; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:1990246; C:uniplex complex; ISS:UniProtKB.
DR   GO; GO:0036444; P:calcium import into the mitochondrion; ISS:UniProtKB.
DR   GO; GO:0051560; P:mitochondrial calcium ion homeostasis; ISS:UniProtKB.
DR   GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; ISS:UniProtKB.
DR   InterPro; IPR018782; MCU_reg.
DR   PANTHER; PTHR33904; PTHR33904; 1.
DR   Pfam; PF10161; DDDD; 1.
PE   3: Inferred from homology;
KW   Calcium; Calcium transport; Ion transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..39
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           40..99
FT                   /note="Essential MCU regulator, mitochondrial"
FT                   /id="PRO_0000296324"
FT   TOPO_DOM        40..56
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H4I9"
FT   TRANSMEM        57..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..99
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H4I9"
SQ   SEQUENCE   99 AA;  10457 MW;  E3F310F8164D3139 CRC64;
     MAARVGVLSV AGFRAAARAG GLLRASKQSS AVSHVPCRTA IATSAGTVLP KPEKVSFGLL
     RVFTVVIPFL YIGTLISKNF AALLEEHDIF VPEDDDDDD