ID   EMSY_DANRE              Reviewed;        1173 AA.
AC   Q7ZUV7;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=BRCA2-interacting transcriptional repressor EMSY {ECO:0000250|UniProtKB:Q7Z589};
GN   Name=emsy {ECO:0000250|UniProtKB:Q7Z589}; ORFNames=zgc:56039;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator which is able to repress transcription, possibly
CC       via its interaction with a multiprotein chromatin remodeling complex
CC       that modifies the chromatin. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC047813; AAH47813.1; -; mRNA.
DR   RefSeq; NP_956278.1; NM_199984.1.
DR   AlphaFoldDB; Q7ZUV7; -.
DR   SMR; Q7ZUV7; -.
DR   STRING; 7955.ENSDARP00000092435; -.
DR   PaxDb; Q7ZUV7; -.
DR   GeneID; 335889; -.
DR   KEGG; dre:335889; -.
DR   CTD; 56946; -.
DR   ZFIN; ZDB-GENE-030131-7832; emsy.
DR   eggNOG; KOG4675; Eukaryota.
DR   InParanoid; Q7ZUV7; -.
DR   OrthoDB; 150416at2759; -.
DR   PhylomeDB; Q7ZUV7; -.
DR   PRO; PR:Q7ZUV7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1240.40; -; 1.
DR   InterPro; IPR033482; EMSY.
DR   InterPro; IPR005491; ENT_dom.
DR   InterPro; IPR036142; ENT_dom-like_sf.
DR   PANTHER; PTHR16500; PTHR16500; 1.
DR   Pfam; PF03735; ENT; 1.
DR   SMART; SM01191; ENT; 1.
DR   SUPFAM; SSF158639; SSF158639; 1.
DR   PROSITE; PS51138; ENT; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; DNA damage; DNA repair; Nucleus; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..1173
FT                   /note="BRCA2-interacting transcriptional repressor EMSY"
FT                   /id="PRO_0000086967"
FT   DOMAIN          16..100
FT                   /note="ENT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00476"
FT   REGION          149..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          676..720
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          797..816
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          905..998
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1020..1046
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1139..1173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        676..692
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        905..925
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        932..980
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1022..1044
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1159..1173
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1173 AA;  122200 MW;  2FBDDAE793CEFCA5 CRC64;
     MPVVWPTLLD LSRDECKRIL RKLELEAYAG VISALRAQGD LTKDKKELLG ELTRVLSIST
     ERHRAEVRRA VNDERLTTIA HHMSGPNSSS EWSIEGRRLV PLMPRLVPQT AFTVMANAVA
     NATAHQNASL PLPAETANKE VVVCYSYTST TSTPPSASAP SSSSAAVKSP RPASPASNVV
     VLPSGSTVYV KSVSCSDEDE KPRKRRRTSS SSSSPVLLKE VPKVAVTAPG PKTITLPVSG
     GPKISNLMQS IANSLPPHMS PVKITFTKPS TQTTNTTTQK VIIVTTSPSS NFVPNILSKS
     HNYAAVSKLV SSAALTASSQ KQTMVISAGG SSVAPGPGPV AVTTVVSSTP SVVMSTVAQA
     GSAAVKVAST RLPSPKALIG SPSQILQIPK AQQAVLQSAA PKALQGSIST AQSTALAAAG
     PGAKPTIQIK QESGVKIITQ QMQPSKILPK PSSAALPSSS SAPIMVVSSN GAIMTTKLVS
     TPTGSASTYT RPTVSPMGTR VATSPAGATY VKTTSGSIIT VVPKALATLG GKIITTSMVS
     GTTTKITTIP MTSKPNVIVV QKTTGKGTTI QGLPGKNVVT TLLNAGGEKT LQAIPGAKPA
     IITASRPITK MIVTQPKSLG AGVQPSTTTK IIPTKIVYGQ QGKTQVLIKP KPMAFQTAVV
     SEQTRQLVSE TLQQVNRSAE NNTTSTHTSA AAAGLENRDD THTYTEGSPV PSDSTHDAPP
     VVHLISSRGQ EWAEQEVSVE SSPALIYQEL TAESQSATST IKALLELQQT SVKEKSEAKP
     RQHTIDLSQM AVPIPVSAEQ RESPEPSGQS AAESDAHTEF IPIGKVSKAA EVSASSTPGQ
     SASAVSAAPH VVKISTAAVT TQQVEAQVKP QQEQVLVEEC ELEGDTLDPQ TGLFYRSSPQ
     QQLSRVCEAA SSSSSSSSSS SRRAEPPLTV KILTHRSSSS APATAASANT PHTPQLPRLQ
     QAPTTHNRPN THTQLSQPPP LQAHHPVGSS KTSSGAQVQQ PIITQGATVT KITFGAPHVP
     RAPVSSSSSS EAALKLQAES SSEKPSVPDI LKISMMEAEI DPGAEPMLVD SSSDCGPLTK
     APAGPSLISS SKQTLAHGPF SRKSKELDII QVIPQYSIMP DSSQSNVVVE PSGFLEISDY
     TSQRLDEEQA MEQEVDSSND EGAAASPSAD QSQ