AGAP5_HUMAN
ID AGAP5_HUMAN Reviewed; 686 AA.
AC A6NIR3; A8MSN5;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5;
DE Short=AGAP-5;
DE AltName: Full=Centaurin-gamma-like family member 2;
GN Name=AGAP5; Synonyms=CTGLF2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative GTPase-activating protein. {ECO:0000305}.
CC -!- MISCELLANEOUS: Encoded by one of the numerous copies of centaurin
CC gamma-like genes clustered in the q11 region of chromosome 10.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family. {ECO:0000305}.
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DR EMBL; AC073389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC022400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC127746; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS44439.1; -.
DR RefSeq; NP_001137472.1; NM_001144000.1.
DR AlphaFoldDB; A6NIR3; -.
DR SMR; A6NIR3; -.
DR BioGRID; 609497; 3.
DR IntAct; A6NIR3; 2.
DR MINT; A6NIR3; -.
DR STRING; 9606.ENSP00000363207; -.
DR iPTMnet; A6NIR3; -.
DR PhosphoSitePlus; A6NIR3; -.
DR BioMuta; AGAP5; -.
DR jPOST; A6NIR3; -.
DR MassIVE; A6NIR3; -.
DR MaxQB; A6NIR3; -.
DR PaxDb; A6NIR3; -.
DR PeptideAtlas; A6NIR3; -.
DR PRIDE; A6NIR3; -.
DR ProteomicsDB; 1279; -.
DR Antibodypedia; 68077; 42 antibodies from 6 providers.
DR DNASU; 729092; -.
DR Ensembl; ENST00000374094.9; ENSP00000363207.4; ENSG00000172650.15.
DR GeneID; 729092; -.
DR KEGG; hsa:729092; -.
DR MANE-Select; ENST00000374094.9; ENSP00000363207.4; NM_001144000.4; NP_001137472.1.
DR UCSC; uc009xri.4; human.
DR CTD; 729092; -.
DR GeneCards; AGAP5; -.
DR HGNC; HGNC:23467; AGAP5.
DR HPA; ENSG00000172650; Low tissue specificity.
DR neXtProt; NX_A6NIR3; -.
DR PharmGKB; PA164715123; -.
DR VEuPathDB; HostDB:ENSG00000172650; -.
DR eggNOG; KOG0705; Eukaryota.
DR GeneTree; ENSGT00940000163475; -.
DR InParanoid; A6NIR3; -.
DR OMA; SQECINL; -.
DR OrthoDB; 751525at2759; -.
DR PhylomeDB; A6NIR3; -.
DR TreeFam; TF317762; -.
DR PathwayCommons; A6NIR3; -.
DR SignaLink; A6NIR3; -.
DR BioGRID-ORCS; 729092; 311 hits in 990 CRISPR screens.
DR GenomeRNAi; 729092; -.
DR Pharos; A6NIR3; Tdark.
DR PRO; PR:A6NIR3; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; A6NIR3; protein.
DR Bgee; ENSG00000172650; Expressed in body of pancreas and 93 other tissues.
DR ExpressionAtlas; A6NIR3; baseline and differential.
DR Genevisible; A6NIR3; HS.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR Gene3D; 1.10.220.150; -; 1.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF57863; SSF57863; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; GTPase activation; Metal-binding; Reference proteome; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..686
FT /note="Arf-GAP with GTPase, ANK repeat and PH domain-
FT containing protein 5"
FT /id="PRO_0000349205"
FT DOMAIN 282..443
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 464..584
FT /note="Arf-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT REPEAT 623..652
FT /note="ANK 1"
FT REPEAT 656..685
FT /note="ANK 2"
FT ZN_FING 479..502
FT /note="C4-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT REGION 205..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 8
FT /note="C -> R (in Ref. 2; BC127746)"
FT /evidence="ECO:0000305"
FT CONFLICT 365
FT /note="K -> E (in Ref. 2; BC127746)"
FT /evidence="ECO:0000305"
FT CONFLICT 482
FT /note="Y -> C (in Ref. 2; BC127746)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 686 AA; 75492 MW; C51D1E96C6179B24 CRC64;
MGNILTCCVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ PAEVTVEVGE
DLHMHHIRDQ EMPEALEFSL SANPEASTIF QRNSQTDALE FNPSANPEAS TIFQRNSQTD
VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL DDSTASQHYL TMTIISVTLE IPHHITQRDA
DRSLSIPDEQ LHSFAVSTVH ITKNRNGGGS LNNYSSSIPS TPSTSQEDPQ FSVPPTANTP
TPVCKRSMRW SNLFTSEKGS HPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW
KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS ACAPISSSKS
NGLSKDMDTG LGDSICFSPS ISSTTSPKLN PPPSPHANKK KHLKKKSTNN FMIVSATGQT
WHFEATTYEE RDAWVQAIQS QILASLQSCE SSKSKSQLTS QSEAMALQSI QNMRGNAHCV
DYETQNPKWA SLNLGVLMCI ECSGIHRSLG TRLSRVRSLE LDDWPVELRK VMSSIGNDLA
NSIWEGSSQG QTKPSVKSTR EEKERWIRSK YEEKLFLAPL PCTELSLGQH LLRATADEDL
QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLA QLLIWYGVDV MARDAHGNTA
LTYARQASSQ ECINVLLQYG CPDECV
