ID   AGAP7_HUMAN             Reviewed;         663 AA.
AC   Q5VUJ5; A6NGH4;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7;
DE            Short=AGAP-7;
DE   AltName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7 pseudogene;
DE   AltName: Full=Centaurin-gamma-like family member 4;
GN   Name=AGAP7P; Synonyms=AGAP7, CTGLF4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
CC   -!- FUNCTION: Putative GTPase-activating protein. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Encoded by one of the numerous copies of centaurin
CC       gamma-like genes clustered in the q11 region of chromosome 10.
CC   -!- SIMILARITY: Belongs to the centaurin gamma-like family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AL589822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q5VUJ5; -.
DR   SMR; Q5VUJ5; -.
DR   BioGRID; 575652; 3.
DR   IntAct; Q5VUJ5; 3.
DR   MINT; Q5VUJ5; -.
DR   iPTMnet; Q5VUJ5; -.
DR   PhosphoSitePlus; Q5VUJ5; -.
DR   BioMuta; HGNC:23465; -.
DR   DMDM; 74756856; -.
DR   jPOST; Q5VUJ5; -.
DR   MassIVE; Q5VUJ5; -.
DR   PaxDb; Q5VUJ5; -.
DR   PeptideAtlas; Q5VUJ5; -.
DR   PRIDE; Q5VUJ5; -.
DR   GeneCards; AGAP7P; -.
DR   HGNC; HGNC:23465; AGAP7P.
DR   neXtProt; NX_Q5VUJ5; -.
DR   InParanoid; Q5VUJ5; -.
DR   PhylomeDB; Q5VUJ5; -.
DR   TreeFam; TF317762; -.
DR   PathwayCommons; Q5VUJ5; -.
DR   SignaLink; Q5VUJ5; -.
DR   Pharos; Q5VUJ5; Tdark.
DR   PRO; PR:Q5VUJ5; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q5VUJ5; protein.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   Gene3D; 1.10.220.150; -; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF57863; SSF57863; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   5: Uncertain;
KW   ANK repeat; GTPase activation; Metal-binding; Reference proteome; Repeat;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..663
FT                   /note="Putative Arf-GAP with GTPase, ANK repeat and PH
FT                   domain-containing protein 7"
FT                   /id="PRO_0000284675"
FT   DOMAIN          259..420
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          441..561
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT   REPEAT          600..629
FT                   /note="ANK 1"
FT   REPEAT          633..662
FT                   /note="ANK 2"
FT   ZN_FING         456..479
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT   REGION          182..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          231..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..250
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   663 AA;  73211 MW;  036912A99532FAE0 CRC64;
     MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAEDRM AGAPMAAAVQ PAEVTVEVGE
     DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE IRRSNCTNHV STVHFSQQYS
     LCSTIFLDDS TAIQHYLTMT IISVTLEIPH HITQRDADRS LSIPDEQLHS FAVSTVHITK
     NRNGGGSLNN YSSSIPSTPS TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD
     KERKAPENHA DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGVL TYYSSLGDYM
     KYIHKKEIDL QTSTIKVPGK WPSLATLACT PISSSKSDGL SKDMDTGLGD SICFSPSISS
     TTIPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF EATTYEERDA WVQAIQSQIL
     ASLQSCESSK SKSQLTSQSE AMALQSIQNM RGNAHCVDCE TQNPKWASLN LGVLMCIECS
     GIHRSLGTRL SRVRSLELDD WPVELRKVMS SIGNDLANSI WEGSSQGRTK PTEKSTREEK
     ERWIRSKYEE KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSRE EVNETCGEGD
     GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI NVLLQYGCPD
     ECV