ID   EMX1_DANRE              Reviewed;         231 AA.
AC   Q804S6;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Homeobox protein EMX1;
DE   AltName: Full=Empty spiracles homolog 1;
DE   AltName: Full=Empty spiracles-like protein 1;
GN   Name=emx1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12617801; DOI=10.1016/s1567-133x(02)00062-5;
RA   Kawahara A., Dawid I.B.;
RT   "Developmental expression of zebrafish emx1 during early embryogenesis.";
RL   Gene Expr. Patterns 2:201-206(2002).
CC   -!- FUNCTION: May function in combinations with OTX1/2 to specify cell
CC       fates in the developing central nervous system. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
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DR   EMBL; AF534523; AAO25957.1; -; mRNA.
DR   RefSeq; NP_937787.1; NM_198144.2.
DR   AlphaFoldDB; Q804S6; -.
DR   SMR; Q804S6; -.
DR   STRING; 7955.ENSDARP00000057809; -.
DR   PaxDb; Q804S6; -.
DR   Ensembl; ENSDART00000057810; ENSDARP00000057809; ENSDARG00000039569.
DR   GeneID; 378964; -.
DR   KEGG; dre:378964; -.
DR   CTD; 2016; -.
DR   ZFIN; ZDB-GENE-031007-7; emx1.
DR   eggNOG; KOG0843; Eukaryota.
DR   GeneTree; ENSGT00940000161476; -.
DR   HOGENOM; CLU_049668_1_0_1; -.
DR   InParanoid; Q804S6; -.
DR   OMA; ETVNHPS; -.
DR   OrthoDB; 1189098at2759; -.
DR   PhylomeDB; Q804S6; -.
DR   TreeFam; TF317015; -.
DR   PRO; PR:Q804S6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000039569; Expressed in pallium and 34 other tissues.
DR   ExpressionAtlas; Q804S6; baseline.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0035777; P:pronephric distal tubule development; IMP:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..231
FT                   /note="Homeobox protein EMX1"
FT                   /id="PRO_0000270143"
FT   DNA_BIND        133..192
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          193..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..231
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   231 AA;  26508 MW;  E0AE706F3309373D CRC64;
     MFSATGKRCF TIESLVAKES PITLEDPIRP TALSYSAPAD SFLNGYQSPA GRALYPNPEL
     VFSETVNHAP LSMHPHQLGS APLQHPHFFG TQHREPLNFY PWVLRNRFFG HRFQGNDVSQ
     DTLLLHGPFA RKPKRIRTAF SPSQLLRLER AFEKNHYVVG AERKQLANSL SLSETQVKVW
     FQNRRTKYKR QKLEEEGPEC TQKKKGNHHI NRWRIATKQT GSEDIDVMSD A