ID   EMX1_XENTR              Reviewed;         233 AA.
AC   Q6GLB9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Homeobox protein EMX1;
DE   AltName: Full=Empty spiracles homolog 1;
DE   AltName: Full=Empty spiracles-like protein 1;
GN   Name=emx1; ORFNames=TNeu052k18.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function in combinations with OTX1/2 to specify cell
CC       fates in the developing central nervous system. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
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DR   EMBL; CR760018; CAJ82390.1; -; mRNA.
DR   EMBL; BC074580; AAH74580.1; -; mRNA.
DR   RefSeq; NP_001005459.1; NM_001005459.1.
DR   AlphaFoldDB; Q6GLB9; -.
DR   SMR; Q6GLB9; -.
DR   STRING; 8364.ENSXETP00000018669; -.
DR   PaxDb; Q6GLB9; -.
DR   DNASU; 448058; -.
DR   GeneID; 448058; -.
DR   KEGG; xtr:448058; -.
DR   CTD; 2016; -.
DR   Xenbase; XB-GENE-920144; emx1.
DR   eggNOG; KOG0843; Eukaryota.
DR   HOGENOM; CLU_1900878_0_0_1; -.
DR   InParanoid; Q6GLB9; -.
DR   OrthoDB; 1189098at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..233
FT                   /note="Homeobox protein EMX1"
FT                   /id="PRO_0000270144"
FT   DNA_BIND        135..194
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          192..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..208
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   233 AA;  26545 MW;  B7005300AF432684 CRC64;
     MFQPAGKRCF TIESLVAKDN PLSSEEPLRP AALPYPGAPA EAFVSGFPSP AGRSLYNNPE
     LVFPETVSHP PLTVHPHQLG ASHLQHPHSF FAPQHRDPLN FYPWVLRNRF FGHRFQGGDV
     SQESLLLHGP FARKPKRIRT AFSPSQLLRL ERAFEKNHYV VGAERKQLAS SLSLSETQVK
     VWFQNRRTKY KRQKLEEEGP DSDQKKKGSH HINRWRLATK QPNGEDIDVT SND