ID   EMX2_BOVIN              Reviewed;         253 AA.
AC   Q17R00;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Homeobox protein EMX2;
DE   AltName: Full=Empty spiracles homolog 2;
DE   AltName: Full=Empty spiracles-like protein 2;
GN   Name=EMX2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor, which in cooperation with EMX2, acts to
CC       generate the boundary between the roof and archipallium in the
CC       developing brain. May function in combinations with OTX1/2 to specify
CC       cell fates in the developing central nervous system (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC118094; AAI18095.1; -; mRNA.
DR   RefSeq; NP_001069313.1; NM_001075845.1.
DR   AlphaFoldDB; Q17R00; -.
DR   SMR; Q17R00; -.
DR   STRING; 9913.ENSBTAP00000003937; -.
DR   PaxDb; Q17R00; -.
DR   Ensembl; ENSBTAT00000003937; ENSBTAP00000003937; ENSBTAG00000003027.
DR   GeneID; 523601; -.
DR   KEGG; bta:523601; -.
DR   CTD; 2018; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003027; -.
DR   VGNC; VGNC:28486; EMX2.
DR   eggNOG; KOG0843; Eukaryota.
DR   GeneTree; ENSGT00940000157425; -.
DR   HOGENOM; CLU_049668_1_0_1; -.
DR   InParanoid; Q17R00; -.
DR   OMA; RWRMETQ; -.
DR   OrthoDB; 1189098at2759; -.
DR   TreeFam; TF317015; -.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000003027; Expressed in mammary gland fat and 78 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR   GO; GO:0007420; P:brain development; IBA:GO_Central.
DR   GO; GO:0021846; P:cell proliferation in forebrain; IEA:Ensembl.
DR   GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR   GO; GO:0021796; P:cerebral cortex regionalization; IEA:Ensembl.
DR   GO; GO:0021542; P:dentate gyrus development; IEA:Ensembl.
DR   GO; GO:0021885; P:forebrain cell migration; IEA:Ensembl.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0072197; P:ureter morphogenesis; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..253
FT                   /note="Homeobox protein EMX2"
FT                   /id="PRO_0000285082"
FT   DNA_BIND        155..214
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          213..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..228
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   253 AA;  28344 MW;  AAE6D2F46786B21E CRC64;
     MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG FHSAAAAAAA
     GRGVYSNPDL VFAEAVSHPP NPAVPVHPVP PPHALAAHPL PSSHSPHPLF ASQQRDPSTF
     YPWLIHRYRY LGHRFQGNDA SPESFLLHNA LARKPKRIRT AFSPSQLLRL EHAFEKNHYV
     VGAERKQLAH SLSLTETQVK VWFQNRRTKF KRQKLEEEGS DSQQKKKGTH HINRWRIATK
     QASPEEIDVT SDD